Development of a method for generating SNP interaction-aware polygenic risk scores for radiotherapy toxicity

Autor: A. Webb, David Azria, Sarah L. Kerns, Karen Foweraker, Ana Carballo, Barbara Avuzzi, Luis Aznar-Garcia, Roxana Draghici, Monica Ramos, Stéphanie Peeters, Benjamin Gauter-Fleckenstein, Daniel S. Higginson, Anna Maria Paganoni, Ulrich Giesche, Monika Kaushik, Corinne Faivre-Finn, Ananya Choudhury, Andrea Manzoni, Jörg Schäfer, Carsten Herskind, Frances Kenny, Paolo Zunino, Valérie Fonteyne, Abigail Pascoe, S. Morlino, Paloma Sosa-Fajardo, Manjusha Keni, Karin Haustermans, A. Giraldo, Jaroslaw Krupa, Claudia Sangalli, Thomas Schnabel, Gert De Meerleer, Yolande Lievens, Patricia Calvo-Crespo, Marie-Pierre Farcy-Jacquet, Petra Seibold, Nicola Rares Franco, Ramón Lobato-Busto, Irene Fajardo-Paneque, Tim Rattay, Ana Vega, Riccardo Valdagni, Elena Delmastro, Irmgard Helmbold, Ben G. L. Vanneste, Richard G. Stock, Donna Appleton, Debbie Payne, Barry S. Rosenstein, Liv Veldeman, Rebecca Elliott, Tiziana Rancati, Alison M. Dunning, Claire P. Esler, Sridhar Thiagarajan, Elisabetta Garibaldi, Muriel Brengues, Michela Carlotta Massi, Simon Pilgrim, Maria C. De Santis, Wilfried De Neve, Miguel E. Aguado-Barrera, Evert J. Van Limbergen, Olivia-Fuentes-Rios, Paul Symonds, Jenny Chang-Claude, Elena Sperk, Catharine M L West, Petra Stegmaier, Antonio Gómez-Caamaño, Marzia Franceschini, Laura Torrado Moya, Simon Wright, Kufre Sampson, Kalliope Valassiadou, Francesca Ieva, Burkhard Neu, Isabel Dominguez-Rios, Francoise Bons, Marie-Luise Sautter-Bihl, Gilles Defraene, Tommaso Giandini, Meritxel Molla, Sheryl Green, Victoria Harrop, Alessandro Cicchetti, Christian Weiß, Caroline Weltens, Gabriele Pietro, Christopher Kent, Michael Ehmann, Paula Peleteiro, Dirk De Ruysscher, Thomas Blaschke, Ion Bioangiu, Hazem Khout, Samuel Lavers, Ahmed Osman, Laura Fachal, Subramaniam Vasanthan, Marc van Eijkeren, Laura Lozza, Céline Bourgier, Kelly Lambert, Johannes Claßen, Piet Ost, Kerstie Johnson, Christian Weißenberger, Bibiana Piqué-Leiva, Timothy H Ward, Christel Monten, Maarten Lambrecht, Marlon R. Veldwijk, Erik van Limberghen, Kiran Kancherla, Christopher J. Talbot, Barbara Noris Chiorda, Erik Briers, Sheila Shokuhi

Publikováno v: RADIOTHERAPY AND ONCOLOGY
Radiotherapy and Oncology, 159, 241-248. Elsevier Ireland Ltd

AIM: To identify the effect of single nucleotide polymorphism (SNP) interactions on the risk of toxicity following radiotherapy (RT) for prostate cancer (PCa) and propose a new method for polygenic risk score incorporating SNP-SNP interactions (PRSi)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a7b893793cb9be0c1758ad6b546648
https://lirias.kuleuven.be/handle/20.500.12942/691375

REQUITE: A prospective multicentre cohort study of patients undergoing radiotherapy for breast, lung or prostate cancer

Autor: Manjusha Keni, Luis Aznar-Garcia, Ben G. L. Vanneste, Miguel E. Aguado-Barrera, Marie-Pierre Farcy-Jacquet, Corinne Faivre-Finn, Marlon R. Veldwijk, Rebecca Elliott, Catharine M L West, Yolande Lievens, Irmgard Helmbold, Ulrich Giesche, Monika Kaushik, Pieter Deseyne, Elena Delmastro, David García-Relancio, Barbara Avuzzi, Marcus Mareel, Timothy H Ward, Marzia Franceschini, Annick Van Greveling, Céline Bourgier, Riccardo Valdagni, Alison M. Dunning, Valérie Fonteyne, Petra Stegmaier, Ana Carballo, Kelly Lambert, Piet Ost, Tom Vercauteren, Christopher Kent, Tim Rattay, Hilary Stobart, Kalliope Valassiadou, Simon Wright, Roxana Draghici, Sheryl Green, F. Duprez, Johannes Claßen, Pietro Gabriele, Kufre Sampson, Patricia Calvo-Crespo, Hazem Khout, V. Reyes, Kerstie Johnson, R. Paul Symonds, Anusha Müller, Laura Torrado-Moya, Ava Golchin, Elhaseen Elhamin, Christian Weiß, Alejandro Seoane-Ramallo, Kiran Kancherla, Ahmed Osman, Irene Fajardo-Paneque, Jörg Schäfer, Hannah Dobbelaere, Soumia Arredouani, Paula Peleteiro, Mónica Ramos-Albiac, Dirk De Ruysscher, Petra Seibold, Manolo Altabas, Claudia Sangalli, Renée Bultijnck, Thiagarajan Sridhar, Marc van Eijkeren, Elena Sperk, Samuel Lavers, Jaroslaw Krupa, A. Giraldo, Martijn Swimberghe, Ana Vega, Christopher J. Talbot, Richard G. Stock, Ion Boiangui, Juan Fernández-Tajes, Claire P. Esler, Sara Gutiérrez-Enríquez, Muriel Brengues, Isabel Dominguez-Rios, Olivia Fuentes-Rios, Daniel S. Higginson, Katrien Vandecasteele, A. Webb, Alessandro Cicchetti, Thomas Blaschke, Maria De Santis, Laura Fachal, Christian Weißenberger, Subramaniam Vasanthan, Bibiana Piqué-Leiva, Laura Lozza, Wilfried De Neve, Maarten Lambrecht, Paloma Sosa-Fajardo, Sheila Shokuhi, Ramón Lobato-Busto, Giselle Post, Carsten Herskind, Frances Kenny, Abigail Pascoe, Belina Rodriguez-Lage, Thomas Schnabel, Donna Appleton, Barry S. Rosenstein, Elisabetta Garibaldi, Christel Monten, Tiziana Rancati, Ananya Choudhury, David Azria, Leen Paelinck, Liv Veldeman, Erik Briers, Begoña Taboada-Valladares, Burkhard Neu, Simon Pilgrim, Jenny Chang-Claude, Antonio Gómez-Caamaño, Gilles Defraene, R Aerts, William Li, Victoria Harrop, S. Morlino, Frank A. Giordano, Debbie Payne, M. Molla, Karen Foweraker

Publikováno v: Radiotherapy and Oncology
Radiotherapy and Oncology, 138, 59-67. Elsevier Ireland Ltd
REQUITE consortium, Choudhury, A, Elliott, R M, Payne, D & West, C M L 2019, ' REQUITE : A prospective multicentre cohort study of patients undergoing radiotherapy for breast, lung or prostate cancer ', Radiotherapy and Oncology, vol. 138, pp. 59-67 . https://doi.org/10.1016/j.radonc.2019.04.034

PURPOSE: REQUITE aimed to establish a resource for multi-national validation of models and biomarkers that predict risk of late toxicity following radiotherapy. The purpose of this article is to provide summary descriptive data. METHODS: An internati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b025c2fd65434de46781dbacb28f4816
https://lirias.kuleuven.be/handle/123456789/638676