Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Laura T, Fee"'
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Akademický článek
C3d Elicits Neutrophil Degranulation and Decreases Endothelial Cell Migration, with Implications for Patients with Alpha-1 Antitrypsin Deficiency
Autor: Laura T. Fee, Debananda Gogoi, Michael E. O’Brien, Emer McHugh, Michelle Casey, Ciara Gough, Mark Murphy, Ann M. Hopkins, Tomás P. Carroll, Noel G. McElvaney, Emer P. Reeves
Publikováno v: Biomedicines, Vol 9, Iss 12, p 1925 (2021)
Alpha-1 antitrypsin (AAT) deficiency (AATD) is characterized by increased risk for emphysema, chronic obstructive pulmonary disease (COPD), vasculitis, and wound-healing impairment. Neutrophils play a central role in the pathogenesis of AATD. Dysregu
Externí odkaz: https://doaj.org/article/fd3974a57e8e4a62945b8c22bb67bc45
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Activation of complement component 3 is associated with airways disease and pulmonary emphysema in alpha-1 antitrypsin deficiency
Autor: Michael Henry, Cormac McCarthy, Emer P. Reeves, Paula Meleady, Oliver J. McElvaney, Karen McQuillan, Mark Logan, Mark P Murphy, Noel G. McElvaney, Michael Emmet O'Brien, Tomás P. Carroll, Niall Browne, Laura T. Fee
Publikováno v: Thorax
IntroductionAlpha-1 antitrypsin (AAT) deficiency (AATD) is associated with early onset emphysema. The aim of this study was to investigate whether AAT binding to plasma constituents could regulate their activation, and in AATD, exploit this binding e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bee9fd9973ea2020fbbb29201378902
https://doi.org/10.1136/thoraxjnl-2019-214076
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Alpha-1 Antitrypsin Deficiency and Tobacco Smoking: Exploring Risk Factors and Smoking Cessation in a Registry Population
Autor: Hamad Alkandari, Andrew Woodsmith, Mansour A. Alkhunaizi, Tomás P. Carroll, Layali Aldaihani, Siobhán E Lee, Alessandro N Franciosi, Laura T Fee, Noel G. McElvaney
Publikováno v: COPD. 18(1)
The ZZ genotype of alpha-1 antitrypsin deficiency (AATD) is strongly associated with COPD, even in never-smokers. Moderate AATD genotypes (MZ and SZ) have been shown to increase the severity of COPD in smokers. In this comparative study, we examine t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d623c40538ad5b395ecf756e5ad0bcd7
https://pubmed.ncbi.nlm.nih.gov/33557645
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4
The impact of alpha-1 antitrypsin augmentation therapy on neutrophil-driven respiratory disease in deficient individuals
Autor: Danielle M Dunlea, Thomas McEnery, Laura T. Fee, Noel G. McElvaney, Emer P. Reeves
Publikováno v: Journal of Inflammation Research
Alpha-1 antitrypsin (AAT) is the most abundant serine protease inhibitor circulating in the blood. AAT deficiency (AATD) is an autosomal codominant condition affecting an estimated 3.4 million individuals worldwide. The clinical disease associated wi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36c41073aa61233fcdb305e0ca85bf2
https://doi.org/10.2147/jir.s156405
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Brief Report: Genetic Variation of the α1 -Antitrypsin Gene Is Associated With Increased Autoantibody Production in Rheumatoid Arthritis
Autor: Geraldine M. McCarthy, Douglas J. Veale, Paul O'Connell, Dermot Kenny, Eimear Dunne, Danielle M Dunlea, Emer P. Reeves, David J. L. Hunt, Carl Orr, Tomás P. Carroll, Ursula Fearon, Laura T. Fee, Noel G. McElvaney, Cormac McCarthy
Publikováno v: Arthritis & Rheumatology. 69:1576-1579
Objective To examine the prevalence of α1-antitrypsin deficiency (AATD) in rheumatoid arthritis (RA), and to determine whether AATD is associated with higher levels of rheumatoid factor (RF), antinuclear antibodies (ANAs), and anti–citrullinated p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::080a5a9a19e924e622bd38a769cce5a4
https://doi.org/10.1002/art.40127
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The Impact of Smoke Exposure on the Clinical Phenotype of Alpha-1 Antitrypsin Deficiency in Ireland: Exploiting a National Registry to Understand a Rare Disease
Autor: Emer P. Reeves, Jonathan Shum, M Emmett O'Brien, Noel G. McElvaney, Tomás P. Carroll, Kevin Pennycooke, Catherine O'Connor, P Mark Logan, Laura T. Fee
Publikováno v: COPD: Journal of Chronic Obstructive Pulmonary Disease. 12:2-9
Individuals with Alpha-1 antitrypsin deficiency (AATD) have mutations in the SERPINA1 gene causing genetic susceptibility to early onset lung and liver disease that may result in premature death. Environmental interactions have a significant impact i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd566faa24b6f569f5cc1e1c33af6f1
https://doi.org/10.3109/15412555.2015.1021913
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Brief Report: Genetic Variation of the α
Autor: Cormac, McCarthy, Carl, Orr, Laura T, Fee, Tomás P, Carroll, Danielle M, Dunlea, David J L, Hunt, Eimear, Dunne, Paul, O'Connell, Geraldine, McCarthy, Dermot, Kenny, Ursula, Fearon, Douglas J, Veale, Emer P, Reeves, Noel G, McElvaney
Publikováno v: Arthritisrheumatology (Hoboken, N.J.). 69(8)
To examine the prevalence of αRF, ANAs, and ACPAs were measured by standard immunoturbidimetry, immunofluorescence assay, and enzyme-linked immunosorbent assay, respectively. Characterization of AAT phenotypes was performed by isoelectric focusing a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cf10ff18ea1cc4c8fd7a4652e0cd7490
https://pubmed.ncbi.nlm.nih.gov/28881426
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The Irish National Alpha-1 Antitrypsin Deficiency Targeted Detection Programme
Autor: Ilaria Ferrarotti, Stefania Ottaviani, Catherine O'Connor, Patrick O'Brien, Maurizio Luisetti, Tomás P. Carroll, Gerry McElvaney, Laura T. Fee
Publikováno v: C25. CHRONIC OBSTRUCTIVE PULMONARY DISEASE: UPDATES ON EPIDEMIOLOGY AND CLINICAL PHENOTYPES.
AAT deficiency (AATD) results from mutations in the SERPINA1 gene, classically presenting with early-onset emphysema and liver disease. The most common mutation responsible for AATD is the Z mutation. AAT deficiency is under-diagnosed and prolonged d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8b3ec9715086722719d56473d5db799
https://doi.org/10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4106
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