Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Laura Sutherland"'
Autor:
Kevin O. Saunders, Norbert Pardi, Robert Parks, Sampa Santra, Zekun Mu, Laura Sutherland, Richard Scearce, Maggie Barr, Amanda Eaton, Giovanna Hernandez, Derrick Goodman, Michael J. Hogan, Istvan Tombacz, David N. Gordon, R. Wes Rountree, Yunfei Wang, Mark G. Lewis, Theodore C. Pierson, Chris Barbosa, Ying Tam, Xiaoying Shen, Guido Ferrari, Georgia D. Tomaras, David C. Montefiori, Drew Weissman, Barton F. Haynes
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-14 (2021)
Abstract The development of an effective AIDS vaccine remains a challenge. Nucleoside-modified mRNAs formulated in lipid nanoparticles (mRNA-LNP) have proved to be a potent mode of immunization against infectious diseases in preclinical studies, and
Externí odkaz:
https://doaj.org/article/19cac807096e43e39da4251a08ade56b
Autor:
Leila Eslamizar, Constantinos Petrovas, David J. Leggat, Kathryn Furr, Michelle L. Lifton, Gail Levine, Steven Ma, Christopher Fletez-Brant, Wesley Hoyland, Madhu Prabhakaran, Sandeep Narpala, Kristin Boswell, Takuya Yamamoto, Hua-Xin Liao, David Pickup, Elizabeth Ramsburg, Laura Sutherland, Adrian McDermott, Mario Roederer, David Montefiori, Richard A. Koup, Barton F. Haynes, Norman L. Letvin, Sampa Santra
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)
Abstract The RV144 HIV-1 vaccine trial has been the only clinical trial to date that has shown any degree of efficacy and associated with the presence of vaccine-elicited HIV-1 envelope-specific binding antibody and CD4+ T-cell responses. This trial
Externí odkaz:
https://doaj.org/article/63b38173c836479fba679161167f0413
Autor:
Fangping Cai, Wei-Hung Chen, Weimin Wu, Julia A Jones, Misook Choe, Neelakshi Gohain, Xiaoying Shen, Celia LaBranche, Amanda Eaton, Laura Sutherland, Esther M Lee, Giovanna E Hernandez, Nelson R Wu, Richard Scearce, Michael S Seaman, M Anthony Moody, Sampa Santra, Kevin Wiehe, Georgia D Tomaras, Kshitij Wagh, Bette Korber, Mattia Bonsignori, David C Montefiori, Barton F Haynes, Natalia de Val, M Gordon Joyce, Kevin O Saunders
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009624 (2021)
A primary goal of HIV-1 vaccine development is the consistent elicitation of protective, neutralizing antibodies. While highly similar neutralizing antibodies (nAbs) have been isolated from multiple HIV-infected individuals, it is unclear whether vac
Externí odkaz:
https://doaj.org/article/49af7daf7eef4bd3a19720f1036c1e68
Autor:
Navid Madani, Amy M. Princiotto, Linh Mach, Shilei Ding, Jérémie Prevost, Jonathan Richard, Bhavna Hora, Laura Sutherland, Connie A. Zhao, Brandon P. Conn, Todd Bradley, M. Anthony Moody, Bruno Melillo, Andrés Finzi, Barton F. Haynes, Amos B. Smith III, Sampa Santra, Joseph Sodroski
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
The HIV Env trimer exhibits a closed confirmation and restricts access to known antibody binding sites. Here the authors show that a small-molecule CD4-mimetic compound binds the HIV Env trimer and enhances antibody-mediated protection in a non-human
Externí odkaz:
https://doaj.org/article/ac213354426e4f05910a41474b6a0b00
Autor:
Kevin O. Saunders, Norbert Pardi, Robert Parks, Sampa Santra, Zekun Mu, Laura Sutherland, Richard Scearce, Maggie Barr, Amanda Eaton, Giovanna Hernandez, Derrick Goodman, Michael J. Hogan, Istvan Tombacz, David N. Gordon, R. Wes Rountree, Yunfei Wang, Mark G. Lewis, Theodore C. Pierson, Chris Barbosa, Ying Tam, Gary R. Matyas, Mangala Rao, Zoltan Beck, Xiaoying Shen, Guido Ferrari, Georgia D. Tomaras, David C. Montefiori, Drew Weissman, Barton F. Haynes
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/ad31d3a69c944a2facbfdeaac1f0e48e
Autor:
Kevin O. Saunders, Laurent K. Verkoczy, Chuancang Jiang, Jinsong Zhang, Robert Parks, Haiyan Chen, Max Housman, Hilary Bouton-Verville, Xiaoying Shen, Ashley M. Trama, Richard Scearce, Laura Sutherland, Sampa Santra, Amanda Newman, Amanda Eaton, Kai Xu, Ivelin S. Georgiev, M. Gordon Joyce, Georgia D. Tomaras, Mattia Bonsignori, Steven G. Reed, Andres Salazar, John R. Mascola, M. Anthony Moody, Derek W. Cain, Mireille Centlivre, Sandra Zurawski, Gerard Zurawski, Harold P. Erickson, Peter D. Kwong, S. Munir Alam, Yves Levy, David C. Montefiori, Barton F. Haynes
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3681-3690 (2017)
The events required for the induction of broad neutralizing antibodies (bnAbs) following HIV-1 envelope (Env) vaccination are unknown, and their induction in animal models as proof of concept would be critical. Here, we describe the induction of plas
Externí odkaz:
https://doaj.org/article/e81ea1bb367e416ea3dab564db722a4e
Autor:
Wilton B. Williams, Jinsong Zhang, Chuancang Jiang, Nathan I. Nicely, Daniela Fera, Kan Luo, M. Anthony Moody, Hua-Xin Liao, S. Munir Alam, Thomas B. Kepler, Akshaya Ramesh, Kevin Wiehe, James A. Holland, Todd Bradley, Nathan Vandergrift, Kevin O. Saunders, Robert Parks, Andrew Foulger, Shi-Mao Xia, Mattia Bonsignori, David C. Montefiori, Mark Louder, Amanda Eaton, Sampa Santra, Richard Scearce, Laura Sutherland, Amanda Newman, Hilary Bouton-Verville, Cindy Bowman, Howard Bomze, Feng Gao, Dawn J. Marshall, John F. Whitesides, Xiaoyan Nie, Garnett Kelsoe, Steven G. Reed, Christopher B. Fox, Kim Clary, Marguerite Koutsoukos, David Franco, John R. Mascola, Stephen C. Harrison, Barton F. Haynes, Laurent Verkoczy
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-20 (2017)
An efficient HIV-1 vaccine will likely depend on eliciting broadly neutralizing antibodies (bnAb). Here the authors analyze the B cell repertoire in macaques and knock-in mice in response to sequential immunization with Env variants that induce a bnA
Externí odkaz:
https://doaj.org/article/69f91741f8e94cd5827c2664a8377d65
Publikováno v:
Arts & Health. :1-16
Autor:
Kevin O. Saunders, James Counts, Victoria Stalls, Robert Edwards, Kartik Manne, Xiaozhi Lu, Bhishem Thakur, Katayoun Mansouri, Yue Chen, Rob Parks, Maggie Barr, Laura Sutherland, Joena Bal, Nicholas Havill, Haiyan Chen, Emily Machiele, Nolan Jamieson, Bhavna Hora, Megan Kopp, Katarzyna Janowska, Kara Anasti, Chuancang Jiang, Sravani Venkatayogi, Amanda Eaton, Rory Henderson, Christopher Barbosa, S. Munir Alam, Sampa Santra, Drew Weissman, M. Anthony Moody, Derek W. Cain, Ying Tam, Mark Lewis, Wilton B. Williams, Kevin Wiehe, David Montefiori, Priyamvada Acharya, Barton F. Haynes
SUMMARYThe CD4 binding site (CD4bs) is a conserved epitope on HIV-1 envelope (Env) that can be targeted by protective broadly neutralizing antibodies (bnAbs). HIV-1 vaccines have not elicited CD4bs bnAbs for many reasons, including the CD4bs is occlu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c4f4f461e186c69e94297d7dd514865
https://doi.org/10.2139/ssrn.4414883
https://doi.org/10.2139/ssrn.4414883
Autor:
Kevin O. Saunders, Robert J. Edwards, Kedamawit Tilahun, Kartik Manne, Xiaozhi Lu, Derek W. Cain, Kevin Wiehe, Wilton B. Williams, Katayoun Mansouri, Giovanna E. Hernandez, Laura Sutherland, Richard Scearce, Robert Parks, Maggie Barr, Todd DeMarco, Chloe M. Eater, Amanda Eaton, Georgeanna Morton, Benjamin Mildenberg, Yunfei Wang, R. Wes Rountree, Mark A. Tomai, Christopher B. Fox, M. Anthony Moody, S. Munir Alam, Sampa Santra, Mark G. Lewis, Thomas N. Denny, George M. Shaw, David C. Montefiori, Priyamvada Acharya, Barton F. Haynes
Publikováno v:
Sci Transl Med
A successful HIV-1 vaccine will require induction of a polyclonal neutralizing antibody (nAb) response, yet vaccine-mediated induction of such a response in primates remains a challenge. We found that a stabilized HIV-1 CH505 envelope (Env) trimer fo