Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Laura Surdi"'
Autor:
Cristina St Pierre, Jane Guo, John D Shin, Laura W Engstrom, Hyun-Hee Lee, Alan Herbert, Laura Surdi, James Baker, Michael Salmon, Sanjiv Shah, J Michael Ellis, Hani Houshyar, Michael A Crackower, Melanie A Kleinschek, Dallas C Jones, Alexandra Hicks, Dennis M Zaller, Stephen E Alves, Ravisankar A Ramadas
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180870 (2017)
While the immune system is essential for the maintenance of the homeostasis, health and survival of humans, aberrant immune responses can lead to chronic inflammatory and autoimmune disorders. Pharmacological modulation of drug targets in the immune
Externí odkaz:
https://doaj.org/article/a511e5553a1e4c19982a055d21745012
Autor:
Yaw Sing Tan, Andrea M. Peier, Anthony W. Partridge, Hung Yi Kristal Kaan, Laura Surdi, Tsz Ying Yuen, Tomi K. Sawyer, Srinivasaraghavan Kannan, Shiying Chen, Berengere Sauvagnat, Jerome Hochman, Shuhui Lim, Peter J. Dandliker, Chandra S. Verma, David P. Lane, Pietro G. A. Aronica, Christopher J. Brown, Charles W. Johannes, Simon Ng, Yu-Chi Juang, Brad Sherborne, Fernando J. Ferrer, Sookhee Ha
Publikováno v:
Bioorganicmedicinal chemistry. 26(10)
Macrocyclic α-helical peptides have emerged as a compelling new therapeutic modality to tackle targets confined to the intracellular compartment. Within the scope of hydrocarbon-stapling there has been significant progress to date, including the fir
Autor:
J. Michael Ellis, Ravisankar A. Ramadas, Hyun-Hee Lee, Laura Surdi, Hani Houshyar, Cristina St. Pierre, Melanie A. Kleinschek, Alan Herbert, John H. Shin, Stephen E. Alves, Dallas C. Jones, James Baker, Michael A. Crackower, Jane Guo, Alexandra Hicks, Sanjiv J. Shah, Laura Engstrom, Dennis M. Zaller, Michael Salmon
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0180870 (2017)
PLoS ONE
PLoS ONE
While the immune system is essential for the maintenance of the homeostasis, health and survival of humans, aberrant immune responses can lead to chronic inflammatory and autoimmune disorders. Pharmacological modulation of drug targets in the immune
Autor:
George N. Nikov, Flobert Tanga, Chris Moxham, Ziping Yang, Chaomin Li, Richard G. Ball, Joshua Close, Richard W. Heidebrecht, Gloria Y. Kwei, Lin Xu, Laura Surdi, Xiaoliu Geng, Candia Kenefic, Sanjiv J. Shah, Dan F. Savage, Valentina V. Jeliazkova-Mecheva, Jennifer Chapnick, Julie Elizabeth Burke, Solomon Kattar, Bethany Hughes, Lily Y. Moy, Sujal V. Deshmukh, Paul Moses, Damaris Diaz, John Kevin Leach, Paul Tempest, John Hendrix, Amanda Markarewicz, Nadya Smotrov, Ilona Kariv, Michael J. McNevin, Ben Munoz, Mark S. Shearman, Thomas A. Miller
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(9)
Alzheimer’s disease is a major unmet medical need with pathology characterized by extracellular proteinaceous plaques comprised primarily of β-amyloid. γ-Secretase is a critical enzyme in the cellular pathway responsible for the formation of a ra
Autor:
Michelle Martinez, Mark S. Shearman, Thomas A. Miller, Yudith Garcia, Alexey Rivkin, Christopher M. Moxham, George N. Nikov, Christopher Hamblett, Laura Surdi, Joon Jung, Sean P. Ahearn, Benito Munoz, Andrew Rosenau, Lily Y. Moy, Flobert Tanga, Minilik Angagaw, Jed L. Hubbs, Richard E. Middleton, Matthew H. Daniels, Phieng Siliphaivanh, Sanjiv J. Shah, Candia M. Kenific, Alexander A. Szewczak, Jamie L. Crispino, Jonathan C. Cruz, Bethany Hughes, Nirah H. Shomer, Stephanie M. Chichetti, Chaomin Li, Karin M. Otte, Michael H. Reutershan, Paula Andrade
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(7)
The development of a novel series of purines as gamma-secretase modulators for potential use in the treatment of Alzheimer's disease is disclosed herein. Optimization of a previously disclosed pyrimidine series afforded a series of potent purine-base
Autor:
Scott C. Berk, Candia M. Kenific, Julie E. Hamill, Paul Secrist, Paul Tempest, Jonathan C. Cruz, Andreas Harsch, Judith C. Fleming, Solomon Kattar, Bethany Hughes, Laura Surdi, Hongmei Wang, William K. Dahlberg, Nicole Ozerova, Thomas A. Miller, Melissa Chenard, Astrid M. Kral, Richard E. Middleton, Joey L. Methot, Alexander A. Szewczak, Anna A. Zabierek
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(4)
The successful application of both solid and solution phase library synthesis, combined with tight integration into the medicinal chemistry effort, resulted in the efficient optimization of a novel structural series of selective HDAC1/HDAC2 inhibitor