Asciminib, a First-in-Class STAMP Inhibitor, Provides Durable Molecular Response in Patients (pts) with Chronic Myeloid Leukemia (CML) Harboring the T315I Mutation: Primary Efficacy and Safety Results from a Phase 1 Trial

Autor: Michael Heinrich, Michael W. Deininger, Andreas Hochhaus, Laura Stenson, Paola Aimone, Fotis Polydoros, Dong-Wook Kim, Gabriel Etienne, Timothy P. Hughes, Massimo Breccia, Philipp le Coutre, Jorge E. Cortes, Fabian Lang, Moshe Talpaz, Juan Luis Steegmann, Jeroen Janssen, Silvia Cacciatore, Michael J. Mauro, Yeow Tee Goh, Delphine Rea

Publikováno v: Blood. 136:47-50

Introduction: Tyrosine kinase inhibitors (TKIs) are an effective therapy for pts with CML. However, resistance to treatment driven by point mutations in the ABL kinase domain, particularly the T315I mutation, represents a clinical challenge. The T315

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8bcb52be13db6a5f9369b332be0df5cb
https://doi.org/10.1182/blood-2020-139677

CML-121: Efficacy and Safety of Asciminib in Heavily Pretreated Patients with Philadelphia Chromosome-Positive (Ph+) Chronic Myeloid Leukemia in Chronic Phase (CML-CP) with Sensitivity to Tyrosine Kinase Inhibitors (TKIs)

Autor: Timothy P. Hughes, Dong-Wook Kim, Delphine Rea, Daniel J. DeAngelo, Philipp le Coutre, Fabian Lang, Fotis Polydoros, Silvia Cacciatore, Jorge E. Cortes, Yeow-Tee Goh, Andreas Hochhaus, Massimo Breccia, Hironobu Minami, Michael J. Mauro, Paola Aimone, Laura Stenson, Moshe Talpaz

Publikováno v: Clinical Lymphoma Myeloma and Leukemia. 20:S235

Context There is a need for new therapies that will improve molecular responses in patients with Ph+ CML lacking deep response to TKIs. Asciminib is a novel, specific BCR-ABL1 inhibitor that binds the myristoyl-binding pocket and is expected to resul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb130e52f3628cd6819894ef799dac8d
https://doi.org/10.1016/s2152-2650(20)30816-8

Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo

Autor: Peter Hokland, Luca Malcovati, Teresa Mortera-Blanco, Paresh Vyas, Mohsen Karimi, Magnus Tobiasson, Lennart Nilsson, Stefan N. Constantinescu, Rikard Erlandsson, John E. Pimanda, Helen Doolittle, Stephen Taylor, Mtakai Ngara, Laura Stenson, Supat Thongjuea, Pierre Fenaux, Onima Chowdhury, Claus Nerlov, David C. Wedge, Peter J. Campbell, Elli Papaemmanuil, Sten Linnarsson, Christian Scharenberg, Dag Josefsen, Andrea Pellagatti, Eva Hellström-Lindberg, Gudrun Göhring, Eleni Giannoulatou, Sten Eirik W. Jacobsen, Qiaolin Deng, Brigitte Schlegelberger, Kristina Anderson, David G. Bowen, Mario Cazzola, Sally Ann Clark, Iain C. Macaulay, Gunnar Kvalheim, Sara Duarte, Adam J. Mead, Sudhir Tauro, Jacqueline Boultwood, Alice Giustacchini, Ingunn Dybedal, Una Kjällquist, Petter S. Woll, Ashwin Unnikrishnan, Mette Holm, Rickard Sandberg

Publikováno v: Woll, P S, Kjällquist, U, Chowdhury, O, Doolittle, H, Wedge, D C, Thongjuea, S, Erlandsson, R, Ngara, M, Anderson, K, Deng, Q, Mead, A J, Stenson, L, Giustacchini, A, Duarte, S, Giannoulatou, E, Taylor, S, Karimi, M, Scharenberg, C, Mortera-Blanco, T, Macaulay, I C, Clark, S A, Dybedal, I, Josefsen, D, Fenaux, P, Hokland, P, Holm, M S, Cazzola, M, Malcovati, L, Tauro, S, Bowen, D, Boultwood, J, Pellagatti, A, Pimanda, J E, Unnikrishnan, A, Vyas, P, Göhring, G, Schlegelberger, B, Tobiasson, M, Kvalheim, G, Constantinescu, S N, Nerlov, C, Nilsson, L, Campbell, P J, Sandberg, R, Papaemmanuil, E, Hellström-Lindberg, E, Linnarsson, S & Jacobsen, S E W 2014, ' Myelodysplastic syndromes are propagated by rare and distinct human cancer stem cells in vivo ', Cancer Cell, vol. 25, no. 6, pp. 794-808 . https://doi.org/10.1016/j.ccr.2014.03.036

Evidence for distinct human cancer stem cells (CSCs) remains contentious and the degree to which differentcancer cells contribute to propagating malignancies in patients remains unexplored. In low- to intermediate-risk myelodysplastic syndromes (MDS)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052834e561f5970d9c35830b2bcf9d78
https://doi.org/10.1016/j.ccr.2014.03.036