Zobrazeno 1 - 10
of 211
pro vyhledávání: '"Laura Spinelli"'
Autor:
Alejandro J Brenes, Maud Vandereyken, Olivia J James, Harriet Watt, Jens Hukelmann, Laura Spinelli, Dina Dikovskaya, Angus I Lamond, Mahima Swamy
Publikováno v:
eLife, Vol 10 (2021)
Tissue-resident intestinal intraepithelial T lymphocytes (T-IEL) patrol the gut and have important roles in regulating intestinal homeostasis. T-IEL include both induced T-IEL, derived from systemic antigen-experienced lymphocytes, and natural T-IEL,
Externí odkaz:
https://doaj.org/article/6e624ebedfb24dd29e8cecd5bdc4e781
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Phosphoinositide 3-kinase p110 delta (PI3K p110δ) is pivotal for CD8+ T cell immune responses. The current study explores PI3K p110δ induction and repression of antigen receptor and cytokine regulated programs to inform how PI3K p110δ directs CD8+
Externí odkaz:
https://doaj.org/article/9aebe30bff8a46058b5f2c5ff58b78db
Autor:
Linda V Sinclair, Andrew JM Howden, Alejandro Brenes, Laura Spinelli, Jens L Hukelmann, Andrew N Macintyre, Xiaojing Liu, Sarah Thomson, Peter M Taylor, Jeffrey C Rathmell, Jason W Locasale, Angus I Lamond, Doreen A Cantrell
Publikováno v:
eLife, Vol 8 (2019)
Immune activated T lymphocytes modulate the activity of key metabolic pathways to support the transcriptional reprograming and reshaping of cell proteomes that permits effector T cell differentiation. The present study uses high resolution mass spect
Externí odkaz:
https://doaj.org/article/7d4cdb633ab44514a668ee05c272cae5
Autor:
Danila Costa, Paolo Maggi, Rosa Anna Cifarelli, Giuseppe Lauria, Rosa Bruno, Laura Spinelli, Fabio Signorile, Caterina Colonna, Giuseppe Pastore, Michele Quarto
Publikováno v:
Microbiologia Medica, Vol 25, Iss 3 (2010)
Genus Nocardia belongs to aerobic Actinomycetes, a wide group of polymorphous Gram+, fixed and acapsusalated, branching, partially acid-fast bacilli. Nocardia organism are ubiquitous, soil-borne actinomycetes that usually infect humans as a result of
Externí odkaz:
https://doaj.org/article/961111330583483da03904587752e75a
Autor:
Pedro M O Ventura, Milica Gakovic, Berenice A Fischer, Laura Spinelli, Giorgia Rota, Shalini Pathak, Hanif J Khameneh, Alessandro Zenobi, Sarah Thomson, Walter Birchmeier, Doreen A Cantrell, Greta Guarda
Publikováno v:
EMBO reports. 23(11)
Anticancer T cells acquire a dysfunctional state characterized by poor effector function and expression of inhibitory receptors, such as PD-1. Blockade of PD-1 leads to T cell reinvigoration and is increasingly applied as an effective anticancer trea
Autor:
Alejandro J. Brenes, Jens L. Hukelmann, Laura Spinelli, Andrew J.M. Howden, Julia M. Marchingo, Linda V. Sinclair, Christina Rollings, Olivia J. James, Iain R Phair, Stephen P. Matthews, Sarah H. Ross, J. Simon C. Arthur, Mahima Swamy, David K. Finlay, Angus I. Lamond, Doreen A. Cantrell
The Immunological Proteome Resource (ImmPRes;http://immpres.co.uk/) is an open access public resource integrating proteomic data generated by large-scale mass-spectrometry analysis of murine hematopoietic populations. The initial focus is T lymphocyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eb6b7aa12c37805d1c91648d60dea911
https://doi.org/10.1101/2022.08.29.505666
https://doi.org/10.1101/2022.08.29.505666
Publikováno v:
Bioscience reports. 42(12)
Granzymes comprise a group of proteases involved in the killing of infected or cancerous cells by the immune system. Although best studied in T cells and natural killer (NK) cells, they are also expressed in some innate immune cells. Granzymes B and
Autor:
Julia M. Marchingo, Doreen A. Cantrell, Andrew J. M. Howden, Laura Spinelli, Marcos Damasio, Jens L. Hukelmann
Publikováno v:
Biochemical Journal. 478:79-98
The integration of multiple signalling pathways that co-ordinate T cell metabolism and transcriptional reprogramming is required to drive T cell differentiation and proliferation. One key T cell signalling module is mediated by extracellular signal-r
Autor:
Harriet Watt, Mahima Swamy, Dina Dikovskaya, Olivia J. James, Alejandro Brenes, Laura Spinelli, Angus I. Lamond, Jens L. Hukelmann, Maud Vandereyken
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
Tissue-resident intestinal intraepithelial T lymphocytes (T-IEL) patrol the gut and have important roles in regulating intestinal homeostasis. T-IEL include both induced T-IEL, derived from systemic antigen-experienced lymphocytes, and natural T-IEL,
Autor:
Laura Spinelli, Harriet Watt, Mahima Swamy, Jens L. Hukelmann, Dina Dikovskaya, Angus I. Lamond, Maud Vandereyken, Olivia J. James, Alejandro Brenes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f021f5a2346f72e4b1a8232394afef72
https://doi.org/10.7554/elife.70055.sa2
https://doi.org/10.7554/elife.70055.sa2