Acylfulvenes covalently interact with thioredoxin as an additional cancer target

Autor: Laura Slappendel, Xiaodan Liu, Michael R. Macarthur, Charles M. Sharpless, Shana J. Sturla

Publikováno v: Frontiers in Chemical Biology, Vol 3 (2024)

Maintaining cellular redox homeostasis is critical for cell viability and growth, with disruptions implicated in cellular responses to chemicals and drugs. This study investigates the interactions between acylfulvenes (AFs), a class of DNA alkylating

Externí odkaz: https://doaj.org/article/b0fa27b5694e463abfed807a66329e43

Iminothioindoxyl as a molecular photoswitch with 100 nm band separation in the visible range

Autor: Mark W. H. Hoorens, Miroslav Medved’, Adèle D. Laurent, Mariangela Di Donato, Samuele Fanetti, Laura Slappendel, Michiel Hilbers, Ben L Feringa, Wybren Jan Buma, Wiktor Szymanski

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

The design of photoswitches which operate in the visible light regime, show a large separation of absorption bands and are functional in various solvents is challenging. Here the authors report Iminothioindoxyls as visible-light operated photoswitche

Externí odkaz: https://doaj.org/article/e057a093f8c545b0918076499a067593

Iminothioindoxyl as a molecular photoswitch with 100 nm band separation in the visible range

Autor: Michiel Hilbers, Ben L. Feringa, Mark W. H. Hoorens, Wybren Jan Buma, Wiktor Szymanski, Adèle D. Laurent, Miroslav Medved, Mariangela Di Donato, Samuele Fanetti, Laura Slappendel

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.17392-17402. ⟨10.1038/s41467-019-10251-8⟩
Nature communications 10 (2019): 2390–2390. doi:10.1038/s41467-019-10251-8
info:cnr-pdr/source/autori:Hoorens, Mark W. H.; Medved, Miroslav; Laurent, Adele D.; Di Donato, Mariangela; Fanetti, Samuele; Slappendel, Laura; Hilbers, Michiel; Feringa, Ben L.; Buma, Wybren Jan; Szymanski, Wiktor/titolo:Iminothioindoxyl as a molecular photoswitch with 100 nm band separation in the visible range/doi:10.1038%2Fs41467-019-10251-8/rivista:Nature communications/anno:2019/pagina_da:2390/pagina_a:2390/intervallo_pagine:2390–2390/volume:10
Nature Communications, 10, pp. 1-11
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications, 10, 1-11
Nature Communications, 10:2390. Nature Publishing Group

Light is an exceptional external stimulus for establishing precise control over the properties and functions of chemical and biological systems, which is enabled through the use of molecular photoswitches. Ideal photoswitches are operated with visibl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27fefa9ec3d76fb602f23f81a86ef304
https://doi.org/10.1038/s41467-019-10251-8