Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Laura Silvian"'
Autor:
Tonika Bohnert, Brian T. Hopkins, Stig Hansen, Laura Silvian, Patrick Cullen, Min Zhong, Stacey A. Heumann, Junfa Fan, Noah Bell, Elisabeth Mertsching, Tracy J. Jenkins, Ella Negrou, Eris Bame, Douglas Marcotte, Kevin L. Otipoby, Michael J. Romanowski, Bob McDowell, Wenjin Yang, Daniel A. Erlanson, Patrick Conlon, Mark T. Cancilla, Minna Bui, Urjana Poreci, Daniel Scott, Tarra Fuchs-Knotts, Jon K. Bowden-Verhoek
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:2905-2913
Since the approval of ibrutinib for the treatment of B-cell malignancies in 2012, numerous clinical trials have been reported using covalent inhibitors to target Bruton's tyrosine kinase (BTK) for oncology indications. However, a formidable challenge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4f47fdcd71f2c89e2f54cba793dfbcb
https://doi.org/10.1016/j.bmc.2019.05.021
https://doi.org/10.1016/j.bmc.2019.05.021
Autor:
Laura Silvian
Publikováno v:
Structural Insights into Gene Expression and Protein Synthesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02689fdc48712ec3730f28a4374f5803
https://doi.org/10.1142/9789811215865_0044
https://doi.org/10.1142/9789811215865_0044
Autor:
Darren P. Baker, Laura Silvian, Edward Lin, Chris Bergeron, Robert M. Arduini, Craig P. Wildes, Catherine Hession, Kevin Guckian, Jean-Christophe Hus, Anthone W. Dunah, Charles C. Banos, Douglas Marcotte
Publikováno v:
Protein Science. 27:672-680
The membrane protein interacting with kinase C1 (PICK1) plays a trafficking role in the internalization of neuron receptors such as the amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptor. Reduction of surface AMPA type receptors on neur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::212ac2b24f808f8365e37735c02e02cb
https://doi.org/10.1002/pro.3361
https://doi.org/10.1002/pro.3361
Autor:
Ella Negrou, Tracy J. Jenkins, Mark T. Cancilla, Douglas Marcotte, Minna Bui, Wenjin Yang, Brian T. Hopkins, Mukush Lulla, Daniel A. Erlanson, Eris Bame, Patrick Conlon, Stig Hansen, Elisabeth Mertsching, Tonika Bohnert, Noah Bell, Daniel Scott, Marx Isaac, Stacey A. Heumann, Junfa Fan, Ying Liu, Tarra Fuchs-Knotts, Laura Silvian, Chuck Gua, YuTing Liu, Jon K. Bowden-Verhoek, Michael J. Romanowski, Bob McDowell, Patrick Cullen, Min Zhong
Publikováno v:
Bioorganic & Medicinal Chemistry. 44:116275
Bruton's tyrosine kinase (BTK) is an essential node on the BCR signaling in B cells, which are clinically validated to play a critical role in B-cell lymphomas and various auto-immune diseases such as Multiple Sclerosis (MS), Pemphigus, and rheumatoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08827c5ed0774a88dae1ef91956919b8
https://doi.org/10.1016/j.bmc.2021.116275
https://doi.org/10.1016/j.bmc.2021.116275
Autor:
Joseph P. Lyssikatos, Douglas Marcotte, Christine Lukacs, Mia Rushe, Kevin Little, Robert M. Arduini, Andrea Bertolotti-Ciarlet, Xin Zhili, Tricia L. May-Dracka, Murugan Paramasivam, Thomas A. Patterson, Govinda Bhisetti, Timothy D. McKee, Kateri Atkins, Michael Cullivan, Thomas Hesson, Laura Silvian, Xin E. Sun
Publikováno v:
Protein Science. 26:152-162
Germinal-center kinase-like kinase (GLK, Map4k3), a GCK-I family kinase, plays multiple roles in regulating apoptosis, amino acid sensing, and immune signaling. We describe here the crystal structure of an activation loop mutant of GLK kinase domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96eef719619818bd5871569040ff4d1d
https://doi.org/10.1002/pro.3062
https://doi.org/10.1002/pro.3062
Autor:
Justin A. Caravella, Daliya Banerjee, Noel A. Powell, Jason D. Fontenot, Andres McKenzie, Istvan J. Enyedy, Victor Sukbong Hong, Douglas Marcotte, Laura Silvian, Jianhua Chao, Kurt Van Vloten
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2459-2463
RORγ plays a critical role in controlling a pro-inflammatory gene expression program in several lymphocyte lineages including T cells, γδ T cells, and innate lymphoid cells. RORγ-mediated inflammation has been linked to susceptibility to Crohn's
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3136b750dc7319912bb39e7e65933a62
https://doi.org/10.1016/j.bmcl.2016.03.109
https://doi.org/10.1016/j.bmcl.2016.03.109
Autor:
Flora Jow, Istvan J. Enyedy, Darren P. Baker, Catherine Hession, Chris Bergeron, Kenneth J. Rhodes, Robert H. Scannevin, Cassandra F. Borenstein, Gnanasambandam Kumaravel, Edward Yin-Shiang Lin, Timothy R. Chan, Anthone W. Dunah, Richard L. Huganir, Laura Silvian, Jinming Zou, Robert M. Arduini, Fang Qian, Ellen Rohde, Kevin Guckian, Marion Wittmann, Douglas Marcotte, Charles C. Banos
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Protein interacting with C kinase (PICK1) is a scaffolding protein that is present in dendritic spines and interacts with a wide array of proteins through its PDZ domain. The best understood function of PICK1 is regulation of trafficking of AMPA rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809e124eb19a18665035c8a00f6cabaf
http://europepmc.org/articles/PMC6128908
http://europepmc.org/articles/PMC6128908
Autor:
Linda C. Burkly, Tricia L. May-Dracka, Jason D. Fontenot, Joe Lyssikatos, Timothy D. McKee, Douglas Marcotte, Laura Silvian, Thomas Hesson, Istvan J. Enyedy, Zhili Xin, Thomas A. Patterson, Margot Brickelmaier, Ping Wu, Mia Rushe, Govinda Bhisetti, Robert M. Arduini, Andrea Bertolotti-Ciarlet, Ellen Cahir-McFarland, Paramasivam Murugan, Kerri Spilker, Hairuo Peng, Kevin Little
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(10)
Germinal center kinase-like kinase (GLK, also known as MAP4K3) has been hypothesized to have an effect on key cellular activities, including inflammatory responses. GLK is required for activation of protein kinase C-θ (PKCθ) in T cells. Controlling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd36ee505e541f06d41f7fbd96e84d0
https://pubmed.ncbi.nlm.nih.gov/29636220
https://pubmed.ncbi.nlm.nih.gov/29636220
Autor:
Lin Zhang, Annie Raditsis, Istvan J. Enyedy, Jianhua Chao, Ishchenko Alexey, Brian Elenbaas, Laura Silvian, Jer Hong Chong, Victor Sukbong Hong, Douglas Marcotte, Junhua Fan, Aparna Hingway, Jean-Yves Le Brazidec, Latika Singh
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:474-480
PIM kinases are implicated in variety of cancers by promoting cell survival and proliferation and are targets of interest for therapeutic intervention. We have identified a low-nanomolar pan-PIM inhibitor (PIM1/2/3 potency 5:14:2nM) using structure b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f957718a29c892d89d0d2f01a1c02c95
https://doi.org/10.1016/j.bmcl.2014.12.041
https://doi.org/10.1016/j.bmcl.2014.12.041
Autor:
Laura Silvian
Publikováno v:
Future medicinal chemistry. 9(14)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74fa3ffc63032c29945bf0a70bc5cf67
https://pubmed.ncbi.nlm.nih.gov/28828898
https://pubmed.ncbi.nlm.nih.gov/28828898