Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Laura Siles"'
Autor:
Laura Siles, Sheila Ruiz-Nogales, Arnau Navinés-Ferrer, Pilar Méndez-Vendrell, Esther Pomares
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 32, Iss , Pp 64-79 (2023)
Inherited retinal dystrophies comprise a broad group of genetic eye diseases without effective treatment. Among them, Stargardt disease is the second most prevalent pathology. This pathology triggers progressive retinal degeneration and vision loss i
Externí odkaz:
https://doaj.org/article/a12e24a087e64b53acef5886a2b23b05
Autor:
Ester Sánchez-Tilló, Leire Pedrosa, Ingrid Vila, Yongxu Chen, Balázs Győrffy, Lidia Sánchez-Moral, Laura Siles, Juan J. Lozano, Anna Esteve-Codina, Douglas S. Darling, Miriam Cuatrecasas, Antoni Castells, Joan Maurel, Antonio Postigo
Publikováno v:
JCI Insight, Vol 8, Iss 20 (2023)
Despite being in the same pathway, mutations of KRAS and BRAF in colorectal carcinomas (CRCs) determine distinct progression courses. ZEB1 induces an epithelial-to-mesenchymal transition (EMT) and is associated with worse progression in most carcinom
Externí odkaz:
https://doaj.org/article/4f52e0f35736437f9fa276db1cd3e738
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113222- (2023)
Summary: Human embryonic stem cells (hESCs) can differentiate into any cell lineage. Here, we report that ZEB1 and ZEB2 promote and inhibit mesodermal-to-myogenic specification of hESCs, respectively. Knockdown and/or overexpression experiments of ZE
Externí odkaz:
https://doaj.org/article/1f9f4cdb9d314484899e60d76dfee739
Publikováno v:
Frontiers in Plant Science, Vol 14 (2023)
IntroductionPlant image datasets have the potential to greatly improve our understanding of the phenotypic response of plants to environmental and genetic factors. However, manual data extraction from such datasets are known to be time-consuming and
Externí odkaz:
https://doaj.org/article/175fdb562e1a4179b87f979de69e53c9
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0290429 (2023)
The improvement of crop yield is a major breeding target and there is a long history of research that has focussed on unravelling the mechanisms and processes that contribute to yield. Quantitative prediction of the interplay between morphological tr
Externí odkaz:
https://doaj.org/article/ec7e824cc3c14200b6d6dc3591cb3890
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3655 (2023)
Achromatopsia is an autosomal recessive disorder, in which cone photoreceptors undergo progressive degeneration, causing color blindness and poor visual acuity, among other significant eye affectations. It belongs to a group of inherited retinal dyst
Externí odkaz:
https://doaj.org/article/f07c702049714af987f5c0d2179207dd
Publikováno v:
Plant Methods, Vol 16, Iss 1, Pp 1-8 (2020)
Abstract Background Obtaining high-quality RNA for gene expression analyses from different seed tissues is challenging due to the presence of various contaminants, such as polyphenols, polysaccharides and lipids which interfere with RNA extraction me
Externí odkaz:
https://doaj.org/article/b034f25908c4415e821c348f46b8bccf
Publikováno v:
Frontiers in Plant Science, Vol 12 (2021)
Seed yield is a complex trait for many crop species including oilseed rape (OSR) (Brassica napus), the second most important oilseed crop worldwide. Studies have focused on the contribution of distinct factors in seed yield such as environmental cues
Externí odkaz:
https://doaj.org/article/62030f120c1b47a98d5c4a4179bc3d70
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Following muscle damage, an inflammatory response is associated to activation of satellite cells, which drive muscle repair. Here, the authors show that upregulation of Zeb1 in macrophages and muscle fibres regulates inflammation, and also show a rol
Externí odkaz:
https://doaj.org/article/fba352a7d17a4354bb83f498fd54b6a6
Autor:
Yongqing Liu, Laura Siles, Xiaoqin Lu, Kevin C. Dean, Miriam Cuatrecasas, Antonio Postigo, Douglas C. Dean
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Transition from premalignant lesion to cancer cell highlights tumor initiation. Here, the authors use a model of K-Ras-initiated lung cancer to document two successive asymmetric divisions, each driven by mitotic polarization of key transcription fac
Externí odkaz:
https://doaj.org/article/df38bfb58c814b399b684abd35f65259