Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Laura Sibley"'
Autor:
Laura Sibley, Charlotte Sarfas, Alexandra L. Morrison, Jessica Williams, Konstantinos Gkolfinos, Adam Mabbutt, William Eckworth, Steve Lawrence, Mike Dennis, Andrew White, Sally Sharpe
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract The BCG vaccine is given to millions of children globally but efficacy wanes over time and differences in the immune systems between infants and adults can influence vaccine efficacy. To this end, 34 rhesus macaques were vaccinated with BCG
Externí odkaz:
https://doaj.org/article/2c2a236866d34cea8189ad6904100b82
Autor:
Andrew D. White, Andy C. Tran, Laura Sibley, Charlotte Sarfas, Alexandra L. Morrison, Steve Lawrence, Mike Dennis, Simon Clark, Sirine Zadi, Faye Lanni, Emma Rayner, Alastair Copland, Peter Hart, Gil Reynolds Diogo, Matthew J. Paul, Miyoung Kim, Fergus Gleeson, Francisco J. Salguero, Mahavir Singh, Matthias Stehr, Simon M. Cutting, Juan I. Basile, Martin E. Rottenberg, Ann Williams, Sally A. Sharpe, Rajko Reljic
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Tuberculosis remains a major health threat globally and a more effective vaccine than the current Bacillus Calmette Guerin (BCG) is required, either to replace or boost it. The Spore-FP1 mucosal vaccine candidate is based on the fusion protein of Ag8
Externí odkaz:
https://doaj.org/article/5d6971450abd4bfbb64716fb58efad30
Autor:
Alexandra L. Morrison, Charlotte Sarfas, Laura Sibley, Jessica Williams, Adam Mabbutt, Mike J. Dennis, Steve Lawrence, Andrew D. White, Mark Bodman-Smith, Sally A. Sharpe
Publikováno v:
Vaccines, Vol 11, Iss 10, p 1604 (2023)
Intravenously (IV) delivered BCG provides superior tuberculosis (TB) protection compared with the intradermal (ID) route in non-human primates (NHPs). We examined how γδ T cell responses changed in vivo after IV BCG vaccination of NHPs, and whether
Externí odkaz:
https://doaj.org/article/8cdbb2b4d36443c98f5fbd9003c1ea1c
Autor:
Teresa Lambe, Alexandra J. Spencer, Kelly M. Thomas, Karen E. Gooch, Stephen Thomas, Andrew D. White, Holly E. Humphries, Daniel Wright, Sandra Belij-Rammerstorfer, Nazia Thakur, Carina Conceicao, Robert Watson, Leonie Alden, Lauren Allen, Marilyn Aram, Kevin R. Bewley, Emily Brunt, Phillip Brown, Breeze E. Cavell, Rebecca Cobb, Susan A. Fotheringham, Ciaran Gilbride, Debbie J. Harris, Catherine M. K. Ho, Laura Hunter, Chelsea L. Kennard, Stephanie Leung, Vanessa Lucas, Didier Ngabo, Kathryn A. Ryan, Hannah Sharpe, Charlotte Sarfas, Laura Sibley, Gillian S. Slack, Marta Ulaszewska, Nadina Wand, Nathan R. Wiblin, Fergus V. Gleeson, Dalan Bailey, Sally Sharpe, Sue Charlton, Francisco J. Salguero, Miles W. Carroll, Sarah C. Gilbert
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Lambe, Spencer, Thomas, Gilbert and colleagues report on the detailed immune profile of rhesus macaques and ferrets vaccinated against SARS-CoV-2 under high dose challenge. Their findings indicate that the ChAdOx1 nCoV-19 (AZD1222) the vaccine induce
Externí odkaz:
https://doaj.org/article/9f8c33e0c50a4a85acb2b5617681d0f4
Autor:
Laura Sibley, Andrew D. White, Karen E. Gooch, Lisa M. Stevens, Rachel Tanner, Ashley Jacobs, Owen Daykin-Pont, Fergus Gleeson, Anthony McIntyre, Randall Basaraba, Simon Clark, Graham Hall, Geoff Pearson, Emma Rayner, Helen McShane, Ann Williams, Mike Dennis, Philip D. Marsh, Sally Sharpe
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract This study describes the use of cynomolgus macaques of Chinese origin (CCM) to evaluate the efficacy and immunogenicity of the BCG vaccine against high dose aerosol Mycobacterium tuberculosis challenge. Progressive disease developed in three
Externí odkaz:
https://doaj.org/article/012f7b94a99f4b9a8b55500c6bbff3f8
Autor:
Laura Sibley, Owen Daykin-Pont, Charlotte Sarfas, Jordan Pascoe, Andrew D. White, Sally Sharpe
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Rhesus (Macaca mulatta) and cynomolgus (Macaca fasicularis) macaques of distinct genetic origin are understood to vary in susceptibility to Mycobacterium tuberculosis, and therefore differences in their immune systems may account for the dif
Externí odkaz:
https://doaj.org/article/0b0b6b8a99334168a66892271de4fa7d
Autor:
Francisco J. Salguero, Andrew D. White, Gillian S. Slack, Susan A. Fotheringham, Kevin R. Bewley, Karen E. Gooch, Stephanie Longet, Holly E. Humphries, Robert J. Watson, Laura Hunter, Kathryn A. Ryan, Yper Hall, Laura Sibley, Charlotte Sarfas, Lauren Allen, Marilyn Aram, Emily Brunt, Phillip Brown, Karen R. Buttigieg, Breeze E. Cavell, Rebecca Cobb, Naomi S. Coombes, Alistair Darby, Owen Daykin-Pont, Michael J. Elmore, Isabel Garcia-Dorival, Konstantinos Gkolfinos, Kerry J. Godwin, Jade Gouriet, Rachel Halkerston, Debbie J. Harris, Thomas Hender, Catherine M. K. Ho, Chelsea L. Kennard, Daniel Knott, Stephanie Leung, Vanessa Lucas, Adam Mabbutt, Alexandra L. Morrison, Charlotte Nelson, Didier Ngabo, Jemma Paterson, Elizabeth J. Penn, Steve Pullan, Irene Taylor, Tom Tipton, Stephen Thomas, Julia A. Tree, Carrie Turner, Edith Vamos, Nadina Wand, Nathan R. Wiblin, Sue Charlton, Xiaofeng Dong, Bassam Hallis, Geoffrey Pearson, Emma L. Rayner, Andrew G. Nicholson, Simon G. Funnell, Julian A. Hiscox, Mike J. Dennis, Fergus V. Gleeson, Sally Sharpe, Miles W. Carroll
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Non-human primates are important animal models for studying SARS-CoV-2 infection. Here, Salguero et al. directly compare rhesus and cynomolgus macaques and show that both species represent COVID-19 disease of mild clinical cases, and provide a lung h
Externí odkaz:
https://doaj.org/article/87631802f4e34ba091e1f0a793783536
Autor:
Andrew D. White, Laura Sibley, Charlotte Sarfas, Alexandra Morrison, Jennie Gullick, Simon Clark, Fergus Gleeson, Anthony McIntyre, Cecilia Lindestam Arlehamn, Alessandro Sette, Francisco J. Salguero, Emma Rayner, Esteban Rodriguez, Eugenia Puentes, Dominick Laddy, Ann Williams, Mike Dennis, Carlos Martin, Sally Sharpe
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)
Abstract A single intradermal vaccination with MTBVAC given to adult rhesus macaques was well tolerated and conferred a significant improvement in outcome following aerosol exposure to M. tuberculosis compared to that provided by a single BCG vaccina
Externí odkaz:
https://doaj.org/article/75a0f9423daa48f5b1801560e5f933f6
Autor:
Andrew D. White, Laura Sibley, Charlotte Sarfas, Alexandra L. Morrison, Kevin Bewley, Colin Churchward, Susan Fotheringham, Konstantinos Gkolfinos, Karen Gooch, Alastair Handley, Holly E. Humphries, Laura Hunter, Chelsea Kennard, Stephanie Longet, Adam Mabbutt, Miriam Moffatt, Emma Rayner, Tom Tipton, Robert Watson, Yper Hall, Mark Bodman-Smith, Fergus Gleeson, Mike Dennis, Francisco J. Salguero, Miles Carroll, Helen McShane, William Cookson, Julian Hopkin, Sally Sharpe
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
The tuberculosis vaccine, Bacille Calmette-Guerin (BCG), also affords protection against non-tuberculous diseases attributable to heterologous immune mechanisms such as trained innate immunity, activation of non-conventional T-cells, and cross-reacti
Externí odkaz:
https://doaj.org/article/ccaf950828974926a6824fc4d8c72894
Autor:
Charlotte Sarfas, Andrew D. White, Laura Sibley, Alexandra L. Morrison, Jennie Gullick, Steve Lawrence, Mike J. Dennis, Philip D. Marsh, Helen A. Fletcher, Sally A. Sharpe
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
In many countries where tuberculosis (TB) is endemic, the Bacillus Calmette–Guérin (BCG) vaccine is given as close to birth as possible to protect infants and children from severe forms of TB. However, BCG has variable efficacy and is not as effec
Externí odkaz:
https://doaj.org/article/23a524431d8548a983dc1bcc98994a67