Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Laura Senovilla"'
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Externí odkaz:
https://doaj.org/article/e039041e2d444f3993fb852e35d48363
Autor:
Lucia Gonzalez-Gutierrez, Omar Motiño, Daniel Barriuso, Juan de la Puente-Aldea, Lucia Alvarez-Frutos, Guido Kroemer, Roberto Palacios-Ramirez, Laura Senovilla
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8836 (2024)
Colorectal cancer (CRC) affects approximately 2 million people worldwide. Obesity is the major risk factor for CRC. In addition, obesity contributes to a chronic inflammatory stage that enhances tumor progression through the secretion of proinflammat
Externí odkaz:
https://doaj.org/article/9fa12d0aaf15436686c331c31b6fce99
Autor:
Lucia Alvarez-Frutos, Daniel Barriuso, Mercedes Duran, Mar Infante, Guido Kroemer, Roberto Palacios-Ramirez, Laura Senovilla
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Breast cancer is the most common malignant neoplasm in women. Despite progress to date, 700,000 women worldwide died of this disease in 2020. Apparently, the prognostic markers currently used in the clinic are not sufficient to determine the most app
Externí odkaz:
https://doaj.org/article/0192e64079294dfb9e4670df4f29242b
Autor:
Jiayin Deng, Lucía G. Gutiérrez, Gautier Stoll, Omar Motiño, Isabelle Martins, Lucía Núñez, José Manuel Bravo-San Pedro, Juliette Humeau, Chloé Bordenave, Juncheng Pan, Hélène Fohrer-Ting, Sylvie Souquere, Gerard Pierron, Claudio Hetz, Carlos Villalobos, Guido Kroemer, Laura Senovilla
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Abstract Pro-apoptotic multi-domain proteins of the BCL2 family such as BAX and BAK are well known for their important role in the induction of mitochondrial outer membrane permeabilization (MOMP), which is the rate-limiting step of the intrinsic pat
Externí odkaz:
https://doaj.org/article/b8e22883032443a5aba0575cbed66635
Autor:
Jiayin Deng, Ai-Ling Tian, Hui Pan, Allan Sauvat, Marion Leduc, Peng Liu, Liwei Zhao, Shuai Zhang, Hui Chen, Valérie Taly, Pierre Laurent-Puig, Laura Senovilla, Yingqiu Li, Guido Kroemer, Oliver Kepp
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-11 (2021)
Abstract Colorectal cancers (CRC) can be classified into four consensus molecular subtypes (CMS), among which CMS1 has the best prognosis, contrasting with CMS4 that has the worst outcome. CMS4 CRC is notoriously resistant against therapeutic interve
Externí odkaz:
https://doaj.org/article/db661fab98d84368a6c5b4303d5f4dd5
Autor:
Daniel Barriuso, Lucia Alvarez-Frutos, Lucia Gonzalez-Gutierrez, Omar Motiño, Guido Kroemer, Roberto Palacios-Ramirez, Laura Senovilla
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6374 (2023)
The B-cell lymphoma 2 (Bcl-2) family of proteins is the main regulator of apoptosis. However, multiple emerging evidence has revealed that Bcl-2 family proteins are also involved in cellular senescence. On the one hand, the different expression of th
Externí odkaz:
https://doaj.org/article/5a6fe169b18047afb6c802539ce2860d
Autor:
Aitziber Buqué, Norma Bloy, Maria Perez-Lanzón, Kristina Iribarren, Juliette Humeau, Jonathan G. Pol, Sarah Levesque, Laura Mondragon, Takahiro Yamazaki, Ai Sato, Fernando Aranda, Sylvère Durand, Alexandre Boissonnas, Jitka Fucikova, Laura Senovilla, David Enot, Michal Hensler, Margerie Kremer, Gautier Stoll, Yang Hu, Chiara Massa, Silvia C. Formenti, Barbara Seliger, Olivier Elemento, Radek Spisek, Fabrice André, Laurence Zitvogel, Suzette Delaloge, Guido Kroemer, Lorenzo Galluzzi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Current preclinical models to investigate human HR + breast cancer progression and response to immunotherapy in vivo are limited. Here, the authors demonstrate that mammary tumours driven by a synthetic progestin combined with an oral carcinogen reca
Externí odkaz:
https://doaj.org/article/a7e37a6ac2cb4091b97dc956fd1c341a
Autor:
Peng Liu, Liwei Zhao, Jonathan Pol, Sarah Levesque, Adriana Petrazzuolo, Christina Pfirschke, Camilla Engblom, Steffen Rickelt, Takahiro Yamazaki, Kristina Iribarren, Laura Senovilla, Lucillia Bezu, Erika Vacchelli, Valentina Sica, Andréa Melis, Tiffany Martin, Lin Xia, Heng Yang, Qingqing Li, Jinfeng Chen, Sylvère Durand, Fanny Aprahamian, Deborah Lefevre, Sophie Broutin, Angelo Paci, Amaury Bongers, Veronique Minard-Colin, Eric Tartour, Laurence Zitvogel, Lionel Apetoh, Yuting Ma, Mikael J. Pittet, Oliver Kepp, Guido Kroemer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Certain chemotherapeutic agents can exert their anticancer effect through indirect immune-dependent mechanism. Here, the authors screen a library of tyrosine kinase inhibitors and show that crizotinib is an effective stimulator of immunogenic cell de
Externí odkaz:
https://doaj.org/article/228ee56caf814e7fbcca341ed093aaed
Publikováno v:
OncoImmunology, Vol 8, Iss 11 (2019)
Anti-tumor immune responses impede tumor formation, and cancers have evolved many mechanisms of immune evasion. Confirming earlier findings, we show that human tumors with high chromosomal instability (CIN+) are significantly less immunogenic, as jud
Externí odkaz:
https://doaj.org/article/7fe11b337a544d26929c9ad9367dffb9
Autor:
Wei Xie, Sabrina Forveille, Kristina Iribarren, Allan Sauvat, Laura Senovilla, Yan Wang, Juliette Humeau, Maria Perez-Lanzon, Heng Zhou, Juan F. Martínez-Leal, Guido Kroemer, Oliver Kepp
Publikováno v:
OncoImmunology, Vol 8, Iss 11 (2019)
Systemic treatment with the active transcription inhibitor lurbinectedin aims at inducing tumor cell death in hyperproliferative neoplasms. Here we show that cell death induced by lurbinectedin reinstates and enhances systemic anticancer immune respo
Externí odkaz:
https://doaj.org/article/5ca8e05fb4d14608aac3d9432beefce4