Casein Kinase 2 dependent phosphorylation of eIF4B regulates BACE1 expression in Alzheimer’s disease

Autor: Barbara Bettegazzi, Laura Sebastian Monasor, Serena Bellani, Franca Codazzi, Lisa Michelle Restelli, Alessio Vittorio Colombo, Nikolaus Deigendesch, Stephan Frank, Takashi Saito, Takaomi C. Saido, Sven Lammich, Sabina Tahirovic, Fabio Grohovaz, Daniele Zacchetti

Publikováno v: Cell Death and Disease, Vol 12, Iss 8, Pp 1-14 (2021)

Abstract Alzheimer’s disease (AD) is the most common age-related neurodegenerative disorder. Increased Aβ production plays a fundamental role in the pathogenesis of the disease and BACE1, the protease that triggers the amyloidogenic processing of

Externí odkaz: https://doaj.org/article/0432a5c706c549658e2f87056cfe8f8a

Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism

Autor: Julia K Götzl, Matthias Brendel, Georg Werner, Samira Parhizkar, Laura Sebastian Monasor, Gernot Kleinberger, Alessio‐Vittorio Colombo, Maximilian Deussing, Matias Wagner, Juliane Winkelmann, Janine Diehl‐Schmid, Johannes Levin, Katrin Fellerer, Anika Reifschneider, Sebastian Bultmann, Peter Bartenstein, Axel Rominger, Sabina Tahirovic, Scott T Smith, Charlotte Madore, Oleg Butovsky, Anja Capell, Christian Haass

Publikováno v: EMBO Molecular Medicine, Vol 11, Iss 6, Pp 1-15 (2019)

Abstract Microglia adopt numerous fates with homeostatic microglia (HM) and a microglial neurodegenerative phenotype (MGnD) representing two opposite ends. A number of variants in genes selectively expressed in microglia are associated with an increa

Externí odkaz: https://doaj.org/article/47eb08eec9b445dda38fa257ed92ac93

Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models

Autor: Laura Sebastian Monasor, Stephan A Müller, Alessio Vittorio Colombo, Gaye Tanrioever, Jasmin König, Stefan Roth, Arthur Liesz, Anna Berghofer, Anke Piechotta, Matthias Prestel, Takashi Saito, Takaomi C Saido, Jochen Herms, Michael Willem, Christian Haass, Stefan F Lichtenthaler, Sabina Tahirovic

Publikováno v: eLife, Vol 9 (2020)

Microglial dysfunction is a key pathological feature of Alzheimer's disease (AD), but little is known about proteome-wide changes in microglia during the course of AD and their functional consequences. Here, we performed an in-depth and time-resolved

Externí odkaz: https://doaj.org/article/de74f8be04d64e159352e6741a9c1929

Glitter in the Darkness? Nonfibrillar β-Amyloid Plaque Components Significantly Impact the β-Amyloid PET Signal in Mouse Models of Alzheimer Disease

Autor: Franz-Josef Gildehaus, Samira Parhizkar, Florian Eckenweber, Matthias Brendel, Axel Rominger, Sabina Tahirovic, Leonie Beyer, Laura Sebastian Monasor, Tanja Blume, Peter Bartenstein, Christian Haass, Christian Sacher, Thomas Arzberger, Gloria Biechele, Jochen Herms, Karin Wind, Stefan F. Lichtenthaler, Barbara von Ungern-Sternberg, Paul Cumming, Michael Willem

Publikováno v: Journal of nuclear medicine 63(1), 117-124 (2022). doi:10.2967/jnumed.120.261858
Biechele, Gloria; Sebastian Monasor, Laura; Wind, Karin; Blume, Tanja; Parhizkar, Samira; Arzberger, Thomas; Sacher, Christian; Beyer, Leonie; Eckenweber, Florian; Gildehaus, Franz-Josef; von Ungern-Sternberg, Barbara; Willem, Michael; Bartenstein, Peter; Cumming, Paul; Rominger, Axel; Herms, Jochen; Lichtenthaler, Stefan; Haass, Christian; Tahirovic, Sabina and Brendel, Matthias (2022). Glitter in the Darkness? Non-fibrillar β-amyloid Plaque Components Significantly Impact the β-amyloid PET Signal in Mouse Models of Alzheimer's Disease. Journal of nuclear medicine, 63(1), pp. 117-124. Society of Nuclear Medicine 10.2967/jnumed.120.261858

Objective: β-amyloid PET (Aβ-PET) is an important tool for quantification of amyloidosis in the brain of suspected Alzheimer's disease (AD) patients and transgenic AD mouse models. Despite the excellent correlation of Aβ-PET with gold standard imm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144581e04654e428b4feb253ae834893
https://pub.dzne.de/record/164000

Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

Autor: Sabina Tahirovic, Harald Steiner, Christian Haass, Laura Sebastian Monasor, Gemma Llovera, Aswin Verhoeven, Samira Parhizkar, Vikramjeet Singh, Edith Winkler, Stefan Roth, Frits Kamp, Corinne Benakis, Martin Dichgans, Alessio Colombo, Rebecca Sadler, Jochen Herms, Andrew J. Macpherson, Finn Peters, Arthur Liesz, Steffanie Heindl, Martin Giera, Mercedes Gomez de Agüero

Publikováno v: Colombo, Alessio Vittorio; Sadler, Rebecca Katie; Llovera, Gemma; Singh, Vikramjeet; Roth, Stefan; Heindl, Steffanie; Sebastian Monasor, Laura; Verhoeven, Aswin; Peters, Finn; Parhizkar, Samira; Kamp, Frits; Gomez de Aguero, Mercedes; Macpherson, Andrew; Winkler, Edith; Herms, Jochen; Benakis, Corinne; Dichgans, Martin; Steiner, Harald; Giera, Martin; Haass, Christian; ... (2021). Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition. eLife, 10 eLife Sciences Publications 10.7554/eLife.59826
eLife, Vol 10 (2021)
eLife
eLife 10, e59826 (2021). doi:10.7554/eLife.59826
eLife, 10. ELIFE SCIENCES PUBLICATIONS LTD

Previous studies have identified a crucial role of the gut microbiome in modifying Alzheimer's disease (AD) progression. However, the mechanisms of microbiome-brain interaction in AD were so far unknown. Here, we identify microbiota-derived short cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44104b5f4c07b0ea472b6cff733ab7e8
https://boris.unibe.ch/159085/1/elife-59826.pdf