Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Laura Scolaro"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 3 (2016)
Experimental and clinical data suggest that pro-angiogenic, pro-inflammatory and mitogenic cytokine leptin can be implicated in ocular neovascularization and other eye pathologies. At least in part, leptin action appears to be mediated through functi
Externí odkaz:
https://doaj.org/article/4fb02ae8e7544f4e96c191bb1d2c4747
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e76437 (2013)
BACKGROUND:Emerging evidence suggests that angiogenic and pro-inflammatory cytokine leptin might be implicated in ocular neovascularization. However, the potential of inhibiting leptin function in ophthalmic cells has never been explored. Here we ass
Externí odkaz:
https://doaj.org/article/93badbce87474d3db28bf8c07a22f1f4
Autor:
John M. Maris, Jo Lynne Rokita, Laura Scolaro, Colin M. Hayes, Komal S. Rathi, Alvin Farrel, Grace E. Coggins
Figure S5 shows the confirmation of differential gene expression between RNA seq samples.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::124664b1e08a8185e67cf472a06c29a3
https://doi.org/10.1158/0008-5472.22422431.v1
https://doi.org/10.1158/0008-5472.22422431.v1
Autor:
Jonathan R. Brody, Jordan M. Winter, John M. Pascal, Charles J. Yeo, Karen E. Knudsen, Michael J. Pishvaian, Nicole Meisner-Kober, Wei Jiang, Eric Londin, Laura Scolaro, Avinoam Nevler, Joseph A. Cozzitorto, Shruti Lal, Carmella Romeo, Akshay R. Kamath, Matthew J. Schiewer, Mahsa Zarei, Saswati N. Chand
PARG rescue in HuR silenced cells restores PARPi resistance. Small-molecule inhibition of HuR prevents its cytoplasmic accumulation, abrogates PARG mRNA regulation and increases PARPi sensitivity, independent of DDR status.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bceb7e3ef902e2e70ae482b29c4ff897
https://doi.org/10.1158/0008-5472.22416705
https://doi.org/10.1158/0008-5472.22416705
Autor:
Jonathan R. Brody, Jordan M. Winter, John M. Pascal, Charles J. Yeo, Karen E. Knudsen, Michael J. Pishvaian, Nicole Meisner-Kober, Wei Jiang, Eric Londin, Laura Scolaro, Avinoam Nevler, Joseph A. Cozzitorto, Shruti Lal, Carmella Romeo, Akshay R. Kamath, Matthew J. Schiewer, Mahsa Zarei, Saswati N. Chand
Doxycycline induction of HuR silencing in MIA PaCa-2 cells (sh290) downregulates PARG expression in vitro and tumor growth in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27cbca6f975a7e2018f6b0b818443577
https://doi.org/10.1158/0008-5472.22416702.v1
https://doi.org/10.1158/0008-5472.22416702.v1
Autor:
Jonathan R. Brody, Jordan M. Winter, John M. Pascal, Charles J. Yeo, Karen E. Knudsen, Michael J. Pishvaian, Nicole Meisner-Kober, Wei Jiang, Eric Londin, Laura Scolaro, Avinoam Nevler, Joseph A. Cozzitorto, Shruti Lal, Carmella Romeo, Akshay R. Kamath, Matthew J. Schiewer, Mahsa Zarei, Saswati N. Chand
HuR silencing results in downregulation of PARG expression, which prevents efficient removal of PAR polymers with or without PARPi stress. Expression and function of other PAR removing enzymes is not affected with HuR silencing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d30a8c36dd805071ddb659360d7ff19
https://doi.org/10.1158/0008-5472.22416711
https://doi.org/10.1158/0008-5472.22416711
Autor:
John M. Maris, Jo Lynne Rokita, Laura Scolaro, Colin M. Hayes, Komal S. Rathi, Alvin Farrel, Grace E. Coggins
Relapsed neuroblastomas are enriched with activating mutations of the RAS–MAPK signaling pathway. The MEK1/2 inhibitor trametinib delays tumor growth but does not sustain regression in neuroblastoma preclinical models. Recent studies have implicate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab51a3f2c94f7ae7c340d290ebf0faa
https://doi.org/10.1158/0008-5472.c.6511223.v1
https://doi.org/10.1158/0008-5472.c.6511223.v1
Autor:
John M. Maris, Jo Lynne Rokita, Laura Scolaro, Colin M. Hayes, Komal S. Rathi, Alvin Farrel, Grace E. Coggins
Table S1 includes MYCN amplification and chromosome 11q status across a panel of 16 neuroblastoma cell lines. Table S2-4 include differentially-expressed genes identified in each of the three differential expression analyses. Table S5 includes unique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e4312d248a9a197bbe42a3d91c36147
https://doi.org/10.1158/0008-5472.22422452.v1
https://doi.org/10.1158/0008-5472.22422452.v1
Autor:
Jonathan R. Brody, Jordan M. Winter, John M. Pascal, Charles J. Yeo, Karen E. Knudsen, Michael J. Pishvaian, Nicole Meisner-Kober, Wei Jiang, Eric Londin, Laura Scolaro, Avinoam Nevler, Joseph A. Cozzitorto, Shruti Lal, Carmella Romeo, Akshay R. Kamath, Matthew J. Schiewer, Mahsa Zarei, Saswati N. Chand
HuR directly binds and regulates poly-ADP ribose glycohydrolase mRNA expression particularly under PARPi stress, but doesn't affect expression of other PAR polymerases or hydrolyzing enzymes.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::391bd3a9966c19991c83d520996223e4
https://doi.org/10.1158/0008-5472.22416717.v1
https://doi.org/10.1158/0008-5472.22416717.v1
Autor:
John M. Maris, Jo Lynne Rokita, Laura Scolaro, Colin M. Hayes, Komal S. Rathi, Alvin Farrel, Grace E. Coggins
This file includes figure legends corresponding to Supplementary Figures S1-6.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18efd922ceccdbda80b59279f0102976
https://doi.org/10.1158/0008-5472.22422449
https://doi.org/10.1158/0008-5472.22422449