Zobrazeno 1 - 10
of 115
pro vyhledávání: '"Laura Schulz"'
Autor:
Mariela Cortés-López, Laura Schulz, Mihaela Enculescu, Claudia Paret, Bea Spiekermann, Mathieu Quesnel-Vallières, Manuel Torres-Diz, Sebastian Unic, Anke Busch, Anna Orekhova, Monika Kuban, Mikhail Mesitov, Miriam M. Mulorz, Rawan Shraim, Fridolin Kielisch, Jörg Faber, Yoseph Barash, Andrei Thomas-Tikhonenko, Kathi Zarnack, Stefan Legewie, Julian König
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Multiple alternative splicing events in CD19 mRNA have been associated with resistance/relapse to CD19 CAR-T therapy in patients with B cell malignancies. Here, by combining patient data and a high-throughput mutagenesis screen, the authors identify
Externí odkaz:
https://doaj.org/article/c08d347a8dc943b8ab905da6ad76b36d
Autor:
Sabine Leerhoff, Arnold Raem, Ernst-Wolfgang Kolbe, Laura Schulz, Kirsten Borchers, Thomas Köhler, Günther Winde, Carmen Kirchner
Publikováno v:
Cancer Treatment and Research Communications, Vol 36, Iss , Pp 100748- (2023)
Introduction: It is worth noting the limitations in sensitivity of the existing biomarkers carcinoembryonic antigen (CEA) and carbohydrate antigen (CA 19-9) in detection of colorectal cancer (CRC). In our study, we address the performance of the liqu
Externí odkaz:
https://doaj.org/article/8e745493be834b7daed3307816e338a0
Autor:
Laura Schulz, Manuel Torres-Diz, Mariela Cortés-López, Katharina E. Hayer, Mukta Asnani, Sarah K. Tasian, Yoseph Barash, Elena Sotillo, Kathi Zarnack, Julian König, Andrei Thomas-Tikhonenko
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-12 (2021)
Abstract Resistance to CD19-directed immunotherapies in lymphoblastic leukemia has been attributed, among other factors, to several aberrant CD19 pre-mRNA splicing events, including recently reported excision of a cryptic intron embedded within CD19
Externí odkaz:
https://doaj.org/article/7a025226aeea4eeeb954f32ea7752bb3
Autor:
Simon Braun, Mihaela Enculescu, Samarth T. Setty, Mariela Cortés-López, Bernardo P. de Almeida, F. X. Reymond Sutandy, Laura Schulz, Anke Busch, Markus Seiler, Stefanie Ebersberger, Nuno L. Barbosa-Morais, Stefan Legewie, Julian König, Kathi Zarnack
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Alternative splicing is a critical step in eukaryotic gene expression but its molecular rules are not fully understood. Here, the authors develop a high-throughput mutagenesis approach to comprehensively characterise determinants of alternative splic
Externí odkaz:
https://doaj.org/article/e09001a3cedf4849a519718409e93dcf
Publikováno v:
Open Mind, Vol 1, Iss 3, Pp 123-135 (2017)
How do we decide what to say to ensure our meanings will be understood? The Rational Speech Act model (RSA; Frank & Goodman, 2012) asserts that speakers plan what to say by comparing the informativity of words in a particular context. We present the
Externí odkaz:
https://doaj.org/article/4434295fcddb496e9428803cb99efe86
Autor:
Kimberly Scott, Laura Schulz
Publikováno v:
Open Mind, Vol 1, Iss 1, Pp 4-14 (2017)
Many important questions about children’s early abilities and learning mechanisms remain unanswered not because of their inherent scientific difficulty but because of practical challenges: recruiting an adequate number of children, reaching special
Externí odkaz:
https://doaj.org/article/9a28c463bd404506806f1bce85c6bbc7
Publikováno v:
Open Mind, Vol 1, Iss 1, Pp 15-29 (2017)
To help address the participant bottleneck in developmental research, we developed a new platform called “Lookit,” introduced in an accompanying article (Scott & Schulz, 2017), that allows families to participate in behavioral studies online via
Externí odkaz:
https://doaj.org/article/cfcc5bfac69141a6bf5c127ac3af478a
Publikováno v:
Frontiers in Psychology, Vol 9 (2018)
In this longitudinal study we examined the stability of exploratory play in infancy and its relation to cognitive development in early childhood. We assessed infants' (N = 130, mean age at enrollment = 12.02 months, SD = 3.5 months; range: 5–19 mon
Externí odkaz:
https://doaj.org/article/25b08df4f15f4f2f848c853b82e5ff2f
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e34061 (2012)
Toddlers readily learn predictive relations between events (e.g., that event A predicts event B). However, they intervene on A to try to cause B only in a few contexts: When a dispositional agent initiates the event or when the event is described wit
Externí odkaz:
https://doaj.org/article/df363392792543b4a2d21710e52eeadf
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42495 (2012)
Adults recognize that if event A predicts event B, intervening on A might generate B. Research suggests that young children have difficulty making this inference unless the events are initiated by goal-directed actions [1]. The current study tested t
Externí odkaz:
https://doaj.org/article/9dabbdd797ba42799fb176b0519a7138