Výsledky vyhledávání - "Laura Sanchez-Vicente"

Causes of hOCT1‐Dependent Cholangiocarcinoma Resistance to Sorafenib and Sensitization by Tumor‐Selective Gene Therapy

Autor: Jesper B. Andersen, María L. Martínez-Chantar, Matías A. Avila, Ruba Al-Abdulla, Laura Sanchez-Vicente, Colm J O'Rourke, Letizia Satriano, Rocio I.R. Macias, Maria J. Monte, Elisa Lozano, Sofía Del Carmen, Maitane Asensio, Jose J.G. Marin, Jesus M. Banales, Oscar Briz, Patricia Munoz-Garrido, Marta Alonso-Peña

Publikováno v: Hepatology. 70:1246-1261

Although the multi-tyrosine kinase inhibitor sorafenib is useful in the treatment of several cancers, cholangiocarcinoma (CCA) is refractory to this drug. Among other mechanisms of chemoresistance, impaired uptake through human organic cation transpo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c745e2a1c2d845892285d5c5bb8dc85a
https://doi.org/10.1002/hep.30656

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Evaluation of the promiscuous component of several bacterial export pumps TolC as a biomarker for toxic pollutants in feedstuffs

Autor: Eduarda Molina-Alcaide, Laura Sanchez-Vicente, Laura Perez-Silva, Jose J.G. Marin, Elisa Herraez

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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A significant risk to the food chain is the presence of noxious pollutants in the feeds of animals whose products are used in human nutrition. Consequently, analytical methods and biosensors have been developed to detect these types of contaminates i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17869d38871f5029d5c7133b3df63685
https://pubmed.ncbi.nlm.nih.gov/30940451

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Chemosensitization of hepatocellular carcinoma cells to sorafenib by β-caryophyllene oxide-induced inhibition of ABC export pumps

Autor: Elisa Lozano, Oscar Briz, Jose J.G. Marin, Laura Sanchez-Vicente, Gabriela Mazzanti, Maria J. Monte, Lorena Abete, Silvia Di Giacomo, Antonella Di Sotto

Publikováno v: Archives of toxicology. 93(3)

Several ATP-binding cassette (ABC) proteins reduce intracellular concentrations of antitumor drugs and hence weaken the response of cancer cells to chemotherapy. Accordingly, the inhibition of these export pumps constitutes a promising strategy to ch

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::662860ffd605fb694cdc6a4302909be9
https://pubmed.ncbi.nlm.nih.gov/30659321

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Usefulness of the MRP2 promoter to overcome the chemoresistance of gastrointestinal and liver tumors by enhancing the expression of the drug transporter OATP1B1

Autor: Elisa Herraez, Laura Sanchez-Vicente, Jose J.G. Marin, Oscar Briz, Rocio I.R. Macias

Publikováno v: Oncotarget

Tumor response to chemotherapy is often limited by drug export through ABC proteins. To overcome this problem, here we have investigated the usefulness of inducing the expression of the multidrug uptake transporter OATP1B1 under the control of the MR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edb94a19092204de318ddb6240708e5
https://pubmed.ncbi.nlm.nih.gov/28423714

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Biodetection of potential genotoxic pollutants entering the human food chain through ashes used in livestock diets

Autor: Eduarda Molina-Alcaide, Jose J.G. Marin, Rogelio Nogales, Laura Sanchez-Vicente, Elisa Herraez, Oscar Briz

Publikováno v: Food chemistry. 205

Ash derived from energy generation is used as a source of minerals in livestock feeds. The microbial biosensor recApr-Luc2 was built to detect genotoxic hazard in recycled ash. Escherichia coli SOS gene (recA, lexA, dinI and umuC) expression in respo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b51eea871e778c8e60c540c54163cb09
https://pubmed.ncbi.nlm.nih.gov/27006217

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Cocarcinogenic effects of intrahepatic bile acid accumulation in cholangiocarcinoma development

Autor: Laura Sanchez-Vicente, Jose J.G. Marin, Elisa Lozano, Oscar Briz, Jesus M. Banales, Elisa Herraez, Rocio I.R. Macias, Maria J. Monte

Publikováno v: Molecular cancer research : MCR. 12(1)

Bile acid accumulation in liver with cholangiolar neoplastic lesions may occur before cholestasis is clinically detected. Whether this favors intrahepatic cholangiocarcinoma development has been investigated in this study. The E. coli RecA gene promo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47f4505692db796d8136fe057cf03a2e
https://pubmed.ncbi.nlm.nih.gov/24255171

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Novel artemisinin derivatives with potential usefulness against liver/colon cancer and viral hepatitis

Autor: Marta R. Romero, Alba D. Maestre, Laura Sanchez-Vicente, Herwig Jansen, Ana B. Gomez-San Miguel, Maria A. Serrano, Jose J.G. Marin, Alba G. Blazquez, Thomas Efferth, Manuel Fernandez-Dolon, Marcelino Álvarez

Publikováno v: Bioorganicmedicinal chemistry. 21(14)

Antitumor and antiviral properties of the antimalaria drug artemisinin from Artemisia annua have been reported. Novel artemisinin derivatives (AD1-AD8) have been synthesized and evaluated using in vitro models of liver/colon cancer and viral hepatiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::454d81701258859be2363750e1e4b82a
https://pubmed.ncbi.nlm.nih.gov/23685181

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