Modulation of Dopamine Receptors on Osteoblasts as a Possible Therapeutic Strategy for Inducing Bone Formation in Arthritis

Autor: Elena Schwendich, Laura Salinas Tejedor, Gernot Schmitz, Markus Rickert, Jürgen Steinmeyer, Stefan Rehart, Styliani Tsiami, Jürgen Braun, Xenofon Baraliakos, Jörg Reinders, Elena Neumann, Ulf Müller-Ladner, Silvia Capellino

Publikováno v: Cells, Vol 11, Iss 10, p 1609 (2022)

Rheumatoid arthritis (RA) is associated with systemic osteoporosis, which leads to severe disability and low quality of life. Current therapies target osteoclasts to reduce bone degradation, but more treatment options would be required to promote bon

Externí odkaz: https://doaj.org/article/6ed04ddd9c7041a9934ba1c8451d0f2e

Modified extracorporeal photopheresis with cells from a healthy donor for acute graft-versus-host disease in a mouse model.

Autor: Holger Budde, Susanne Kolb, Laura Salinas Tejedor, Gerald Wulf, Holger M Reichardt, Joachim Riggert, Tobias J Legler

Publikováno v: PLoS ONE, Vol 9, Iss 8, p e105896 (2014)

Graft-versus-host disease (GvHD) is a major challenge after hematopoietic stem cell transplantation but treatment options for patients are still limited. In many cases first-line treatment with glucocorticoids is not successful. Among second-line the

Externí odkaz: https://doaj.org/article/2e238de72c054bf5b64b5bef5c409d99

The Effect of Stereotactic Injections on Demyelination and Remyelination: a Study in the Cuprizone Model

Autor: Thomas Skripuletz, Tanja Wostradowski, Viktoria Gudi, Martin Stangel, Stefan Gingele, Laura Salinas Tejedor

Publikováno v: Journal of Molecular Neuroscience. 61:479-488

Remyelination is the natural repair mechanism in demyelinating disorders of the central nervous system (CNS) such as multiple sclerosis. Several animal models have been used to study demyelination and remyelination. Among toxic animal models, oral ad

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b3c5f655395f76deac8bdfed88447b
https://doi.org/10.1007/s12031-017-0888-y

Mesenchymal stem cells do not exert direct beneficial effects on CNS remyelination in the absence of the peripheral immune system

Autor: Nicole Jungwirth, Laura Salinas Tejedor, Stefan Gingele, Thomas Skripuletz, Viktoria Gudi, Martin Stangel, Wolfgang Baumgärtner, Gabriel Berner, Florian Hansmann, Kristin Jacobsen, Andrea Hoffmann, Chittappen K. Prajeeth

Publikováno v: Brain, Behavior, and Immunity. 50:155-165

Remyelination is the natural repair mechanism in demyelinating disorders such as multiple sclerosis (MS) and it was proposed that it might protect from axonal loss. For unknown reasons, remyelination is often incomplete or fails in MS lesions and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd3da707b2eb8fb0f87a430edc6b24e9
https://doi.org/10.1016/j.bbi.2015.06.024

Synaptophysin Is a Reliable Marker for Axonal Damage

Autor: Markus Kipp, Kurt-Wolfram Sühs, Sandra Amor, Martin Stangel, Wolfgang Baumgärtner, Andreas Beineke, Lijie Gai, Viktoria Gudi, Vanessa Herder, Florian Hansmann, Thomas Skripuletz, Laura Salinas Tejedor

Publikováno v: Gudi, V, Gai, L, Herder, V, Tejedor, L S, Kipp, M, Amor, S, Sühs, K-W, Hansmann, F, Beineke, A, Baumgärtner, W, Stangel, M & Skripuletz, T 2017, ' Synaptophysin Is a Reliable Marker for Axonal Damage ', Journal of Neuropathology and Experimental Neurology, vol. 76, no. 2, pp. 109-125 . https://doi.org/10.1093/jnen/nlw114
Journal of Neuropathology and Experimental Neurology, 76(2), 109-125. Lippincott Williams and Wilkins

Synaptophysin is an abundant membrane protein of synaptic vesicles. The objective of this study was to determine the utility of identifying synaptophysin accumulations (spheroids/ovoids/bulbs) in CNS white matter as an immunohistochemical marker of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3edfdefb5d3f96ceb18a4f7a0ea186f4
https://research.vumc.nl/en/publications/7ced7595-efbd-488d-a48c-fab1f8a5d075