Zobrazeno 1 - 10
of 122
pro vyhledávání: '"Laura S. Itzhaki"'
Autor:
Sam Crawshaw, Alex M. Murphy, Pamela J. E. Rowling, Daniel Nietlispach, Laura S. Itzhaki, John P. Carr
Publikováno v:
Viruses, Vol 16, Iss 5, p 676 (2024)
The cucumber mosaic virus (CMV) 2b protein is a suppressor of plant defenses and a pathogenicity determinant. Amongst the 2b protein’s host targets is the RNA silencing factor Argonaute 1 (AGO1), which it binds to and inhibits. In Arabidopsis thali
Externí odkaz:
https://doaj.org/article/b48d9ac49e094738a1ff4c5558998211
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
E3s comprise a structurally diverse group of at least 800 members, most of which target multiple substrates through specific and regulated protein-protein interactions. These interactions typically rely on short linear motifs (SLiMs), called “degro
Externí odkaz:
https://doaj.org/article/4c3c2948f0f044d6926676fe8e6c6601
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
The Wnt signalling pathway plays key roles in cell proliferation, differentiation and fate decisions in embryonic development and maintenance of adult tissues, and the twelve Armadillo (ARM) repeat-containing protein β-catenin acts as the signal tra
Externí odkaz:
https://doaj.org/article/62aa54168eef4f8195b0396f0d261dee
Publikováno v:
Current Research in Structural Biology, Vol 3, Iss , Pp 30-40 (2021)
Alpha-helical repeat proteins such as consensus-designed tetratricopeptide repeats (CTPRs) are exceptionally stable molecules that are able to tolerate destabilizing sequence alterations and are therefore becoming increasingly valued as a modular pla
Externí odkaz:
https://doaj.org/article/7d5557d63df34de3ae03be98c2561f58
Autor:
Liza Bergkvist, Zhen Du, Greta Elovsson, Hanna Appelqvist, Laura S. Itzhaki, Janet R. Kumita, Katarina Kågedal, Ann‐Christin Brorsson
Publikováno v:
FEBS Open Bio, Vol 10, Iss 3, Pp 338-350 (2020)
Alzheimer's disease (AD) is the most common form of dementia, affecting millions of people and currently lacking available disease‐modifying treatments. Appropriate disease models are necessary to investigate disease mechanisms and potential treatm
Externí odkaz:
https://doaj.org/article/d3371f795ac8455391516ee6c99ced82
Autor:
Krishna Sharma, Alexander V. Strizhak, Elaine Fowler, Wenshu Xu, Ben Chappell, Hannah F. Sore, Warren R. J. D. Galloway, Matthew N. Grayson, Yu Heng Lau, Laura S. Itzhaki, David R. Spring
Publikováno v:
ACS Omega, Vol 5, Iss 2, Pp 1157-1169 (2020)
Externí odkaz:
https://doaj.org/article/a7256e48620f45649f861cdf2b5f5602
Autor:
Catherine K. Xu, Marta Castellana-Cruz, Serene W. Chen, Zhen Du, Georg Meisl, Aviad Levin, Benedetta Mannini, Laura S. Itzhaki, Tuomas P. J. Knowles, Christopher M. Dobson, Nunilo Cremades, Janet R. Kumita
Publikováno v:
Molecules, Vol 27, Iss 4, p 1293 (2022)
A wide variety of oligomeric structures are formed during the aggregation of proteins associated with neurodegenerative diseases. Such soluble oligomers are believed to be key toxic species in the related disorders; therefore, identification of the s
Externí odkaz:
https://doaj.org/article/22de59ffd416471b9dbd2a4adc27aee5
Publikováno v:
Biomolecules, Vol 11, Iss 6, p 827 (2021)
The Wnt signalling pathway plays an important role in cell proliferation, differentiation, and fate decisions in embryonic development and the maintenance of adult tissues. The twelve armadillo (ARM) repeat-containing protein β-catenin acts as the s
Externí odkaz:
https://doaj.org/article/bfecbe2650b54b82923b87a4a6e015fa
Autor:
Alexander P. M. Guttenplan, Laurence J. Young, Dijana Matak-Vinkovic, Clemens F. Kaminski, Tuomas P. J. Knowles, Laura S. Itzhaki
Publikováno v:
Journal of Nanobiotechnology, Vol 15, Iss 1, Pp 1-8 (2017)
Abstract Background Due to their natural tendency to self-assemble, proteins and peptides are important components for organic nanotechnology. One particular class of peptides of recent interest is those that form amyloid fibrils, as this self-assemb
Externí odkaz:
https://doaj.org/article/10abcbb03b3f40c88b049de03a91311b
Autor:
Albert Perez-Riba, Laura S. Itzhaki
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-6 (2017)
Abstract Quantitative determination of protein thermodynamic stability is fundamental to many research areas, both basic and applied. Although chemical-induced denaturation is the gold-standard method, it has been replaced in many settings by semi-qu
Externí odkaz:
https://doaj.org/article/196710379eb84a428f97cdd9d2fb2f5d