Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Laura S. Collins"'
Autor:
Paul W. Finn, James Ritchie, Valentina Semenikhina, Einars Loza, Anthony Tumber, Daina Lola, Nagma Khan, Vija Gailite, Ivars Kalvinsh, Laura S. Collins, Kamille Dumong Petersen, Sree M. Vadlamudi, Maxwell Sehested, Victor Andrianov, Fredrik Björkling
Publikováno v:
European Journal of Medicinal Chemistry. 44:1067-1085
Enzymatic inhibition of histone deacetylase (HDAC) activity is emerging as an innovative and effective approach for the treatment of cancer. A series of novel amide derivatives have been synthesized and evaluated for their ability to inhibit human HD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63503eed765cc55b5b48536b36827c22
https://doi.org/10.1016/j.ejmech.2008.06.020
https://doi.org/10.1016/j.ejmech.2008.06.020
Autor:
Sampath Kumar, Ferenc L. Boldog, Michael Jeffers, James Ritchie, Evan Mills, Paul W. Finn, Stanny C Berghs, Maxwell Sehested, Henri S. Lichenstein, Xiaozhong Qian, Craig Hackett, Nagma Khan, Nicholai Khramtsov, Anthony Tumber, Peter Buhl Jensen, Laura S. Collins, Nessa Carey
Publikováno v:
Biochemical Journal. 409:581-589
The human HDAC (histone deacetylase) family, a well-validated anticancer target, plays a key role in the control of gene expression through regulation of transcription. While HDACs can be subdivided into three main classes, the class I, class II and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34362962d8532db35faf9d6863b4158
https://doi.org/10.1042/bj20070779
https://doi.org/10.1042/bj20070779
Autor:
Laura S. Collins, Annemette Thougaard, Sanne J. Christiansen, Peter Buhl Jensen, Maxwell Sehested, James Ritchie, Anthony Tumber, Marielle Dejligbjerg, Kamille Dumong Petersen
Publikováno v:
Cancer Chemotherapy and Pharmacology. 60:275-283
Histone deacetylase inhibitors (HDACi) inhibit the growth of cancer cells, and combinations of HDACi with established chemotherapeutics can lead to synergistic effects. We have investigated effects of PXD101 (HDACi in phase II clinical trials) in com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::747025d72da6ce758afe011e5f6c469f
https://doi.org/10.1007/s00280-006-0374-7
https://doi.org/10.1007/s00280-006-0374-7
Autor:
Marielle Dejligbjerg, Maxwell Sehested, Xiaozhong Qian, Morten Grauslund, Peter Buhl Jensen, Thomas Litman, Michael Jeffers, Henri S. Lichenstein, Laura S. Collins
Publikováno v:
Molecular Cancer, Vol 7, Iss 1, p 70 (2008)
Molecular Cancer
Molecular Cancer
Background Histone acetylation is an epigenetic modification involved in the regulation of gene expression, balanced by histone acetyl transferases and histone deacetylase (HDAC) enzymes. HDAC inhibitors (HDACi) induce growth arrest and cell death in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1438512497a2bbc896d24c7445eb691d
http://www.molecular-cancer.com/content/7/1/70
http://www.molecular-cancer.com/content/7/1/70
Autor:
Paul W. Finn, Lone Jensen, P. Buhl Jensen, Maxwell Sehested, Nagma Khan, A. Finn, Laura S. Collins, Fiona McLaughlin
Publikováno v:
European Journal of Cancer Supplements. 2:103
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91667ddc2212f10e9addc44d6d3d9999
https://doi.org/10.1016/s1359-6349(04)80346-x
https://doi.org/10.1016/s1359-6349(04)80346-x
Publikováno v:
International journal of radiation oncology, biology, physics. 16(2)
The effect of elevated temperature on the cytotoxicity and interaction with DNA of a series of platinum(II) complexes was examined. CDDP showed greater enhancement in cell killing with heat than the other platinum(II) complexes. There were approximat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79578f019f9ebda52f6c135ad746dc2a
https://pubmed.ncbi.nlm.nih.gov/2646254
https://pubmed.ncbi.nlm.nih.gov/2646254
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 13:165-166
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a107a432b42b41f8437d7ef67c5e284
https://doi.org/10.1016/0360-3016(87)91161-8
https://doi.org/10.1016/0360-3016(87)91161-8