Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Laura S Van Winkle"'
Autor:
Krista M. Cosert, Soohyun Kim, Iman Jalilian, Maggie Chang, Brooke L. Gates, Kent E. Pinkerton, Laura S. Van Winkle, Vijay Krishna Raghunathan, Brian C. Leonard, Sara M. Thomasy
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 981 (2022)
The ocular surface, comprised of the transparent cornea, conjunctiva, and protective tear film, forms a protective barrier defending deeper structures of the eye from particulate matter and mechanical trauma. This barrier is routinely exposed to a mu
Externí odkaz:
https://doaj.org/article/46c94d48a54d460e80074aa7cbc0974b
Publikováno v:
Redox Biology, Vol 34, Iss , Pp 101530- (2020)
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor regulating the expression of genes, for instance encoding the monooxygenases cytochrome P450 (CYP) 1A1 and CYP1A2, which are important enzymes in metabolism of xenobiotics
Externí odkaz:
https://doaj.org/article/ab05ecca1da041b08fb9515e0af7a0dc
Publikováno v:
Antioxidants, Vol 11, Iss 2, p 219 (2022)
Paraquat (PQ) is an agrochemical known to cause pulmonary fibrosis. PQ-induced collagen deposition in the lung is thought to require enzymatic formation of PQ radicals, but the specific enzymes responsible for this bioactivation event in vivo have no
Externí odkaz:
https://doaj.org/article/59d02f316c6647e8a2658e63c378bdc3
Autor:
Nathanial C Stevens, Veneese J Brown, Morgan C Domanico, Patricia C Edwards, Laura S Van Winkle, Oliver Fiehn
Publikováno v:
Toxicological Sciences. 191:79-89
Asthma is a common chronic respiratory disease exacerbated by multiple environmental factors. Acute ozone exposure has previously been implicated in airway inflammation, airway hyperreactivity, and other characteristics of asthma, which may be attrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d41d76dd238dc259d2cd0a0e7c60c3a5
https://doi.org/10.1093/toxsci/kfac117
https://doi.org/10.1093/toxsci/kfac117
Autor:
Huong Huynh, Priya Upadhyay, Cora H. Lopez, Malia K. Miyashiro, Laura S. Van Winkle, Sara M. Thomasy, Kent E. Pinkerton
Publikováno v:
Toxicologic pathology, vol 50, iss 6
Toxicol Pathol
Toxicol Pathol
Engineered silver nanoparticles (AgNPs), including silver silicate nanoparticles (Ag-SiO2 NPs), are used in a wide variety of medical and consumer applications. Inhaled AgNPs have been found to translocate to the olfactory bulb (OB) after inhalation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24c5ca81aaf8307cbd9c09208ae5053
https://doi.org/10.1177/01926233221107607
https://doi.org/10.1177/01926233221107607
Autor:
Atsuhiko Fukuto, Jennifer Kang, Brooke L. Gates, Kimberley Sannajust, Kent E. Pinkerton, Laura S. Van Winkle, Yoshiaki Kiuchi, Brian C. Leonard, Sara M. Thomasy
Publikováno v:
Exp Eye Res
Graphene-based nanomaterials (GBNs) are widely used due to their chemical and physical properties for multiple commercial and environmental applications. From an occupational health perspective, there is concern regarding the effects of inhalation on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1a446a67d4b6342931e8a208871f654
https://escholarship.org/uc/item/5dj9x1pm
https://escholarship.org/uc/item/5dj9x1pm
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 51(1)
Most transgenic mouse models are generated through random integration of the transgene. The location of the transgene provides valuable information for assessing potential effects of the transgenesis on the host and for designing genotyping protocols
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c8985620f17d96c5d9765b4ad83292
https://pubmed.ncbi.nlm.nih.gov/36273825
https://pubmed.ncbi.nlm.nih.gov/36273825
Autor:
Morgan Domanico, Atsuhiko Fukuto, Lisa M. Tran, Jessica-Miranda Bustamante, Patricia C. Edwards, Kent E. Pinkerton, Sara M. Thomasy, Laura S. Van Winkle
Two-dimensional (2D) engineered nanomaterials are widely used in consumer and industrial goods due to their unique chemical and physical characteristics. Engineered nanomaterials are incredibly small and capable of being aerosolized during manufactur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be68fe8895dd82ba8e84f59a38220f5
https://escholarship.org/uc/item/5kf2b43c
https://escholarship.org/uc/item/5kf2b43c
Publikováno v:
Toxicol Sci
Previous studies have established that cytochrome P450 enzymes (CYPs) in both liver and lung are capable of bioactivating naphthalene (NA), an omnipresent air pollutant and possible human carcinogen, in vitro and in vivo. The aim of this study was to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47282ca905e8b5637cf6089df23c7996
https://doi.org/10.1093/toxsci/kfaa114
https://doi.org/10.1093/toxsci/kfaa114
Autor:
Isabella Annesi-Maesano, Urmila P. Kodavanti, Frank D. Gilliland, Esteban G. Burchard, Christopher Carlsten, Haneen Khreis, Carl W. White, Rob McConnell, George D. Thurston, Steven R. Kleeberger, Erika Garcia, Joan Reibman, Laura S. Van Winkle, John R. Balmes, Jack R. Harkema, Kent E. Pinkerton, Mary B. Rice, Dave B Peden, Tamara Schikowski, Stephanie J. London
Publikováno v:
Annals of the American Thoracic Society
Annals of the American Thoracic Society, vol 17, iss 4
Annals of the American Thoracic Society, vol 17, iss 4
Although it is well accepted that air pollution exposure exacerbates preexisting airway disease, it has not been firmly established that long-term pollution exposure increases the risk of new-onset asthma or chronic obstruction pulmonary disease (COP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5852259e26d3d2611d27ebcd35890b9a
https://doi.org/10.1513/annalsats.202001-046st
https://doi.org/10.1513/annalsats.202001-046st