Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Laura S Lubbers"'
Autor:
Bennett Ma, Gregg Wesolowski, Bin Luo, Traci Lifsted, Keith Wessner, Gary Adamson, Helmut Glantschnig, Laura S Lubbers
Publikováno v:
Journal of Circulating Biomarkers, Vol 8 (2019)
Cathepsin K (CatK) inhibitors exhibited chondroprotective and pain-reducing effects in animal models, however, improvements were relatively modest at dose levels achieving maximal suppression of CatK biomarkers in urine. In this report, a previously
Externí odkaz:
https://doaj.org/article/c88a6d1ab14d4b28be9255d748dd81aa
Autor:
Sloka S. Iyengar, Laura S. Lubbers, Lauren Harte‐Hargrove, CURE Epilepsy Post‐Traumatic Initiative Advisors, and Investigators
Publikováno v:
Epilepsia Open, Vol 8, Iss 3, Pp 820-833 (2023)
Abstract Objective Post‐traumatic epilepsy (PTE) is an acquired epilepsy that develops in the months or years following a traumatic brain injury (TBI) and can lead to substantial personal, financial, and societal burden. To date, PTE is rarely cura
Externí odkaz:
https://doaj.org/article/1f68d7e476554ced9636772f3badff14
Autor:
Juliet K. Knowles, Ingo Helbig, Cameron S. Metcalf, Laura S. Lubbers, Lori L. Isom, Scott Demarest, Ethan M. Goldberg, Alfred L. George, Holger Lerche, Sarah Weckhuysen, Vicky Whittemore, Samuel F. Berkovic, Daniel H. Lowenstein
Publikováno v:
Epilepsia
Epilepsia, vol 63, iss 10
Epilepsia, vol 63, iss 10
The genetic basis of many epilepsies is increasingly understood, giving rise to the possibility of precision treatments tailored to specific genetic etiologies. Despite this, current medical therapy for most epilepsies remains imprecise, aimed primar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc37c7a6dbab7d236face95b118cb3bd
https://doi.org/10.1111/epi.17332
https://doi.org/10.1111/epi.17332
Autor:
Mary Wolf, Idriss Bennacef, Hyking Haley, Terence G. Hamill, G Wesolowski, Shawn J. Stachel, Le T. Duong, Mangay Williams, Diane J. Posavec, Mona Purcell, Eric D. Hostetler, Jeffrey L. Evelhoch, Marie A. Holahan, Daniel Rubins, Laura S. Lubbers, Kerry Riffel
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 64:159-167
The cathepsin K (CatK) enzyme is abundantly expressed in osteoclasts, and CatK inhibitors have been developed for the treatment of osteoporosis. In our effort to support discovery and clinical evaluations of a CatK inhibitor, we sought to discover a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d62580f174113b1cfb6b8736aeffe3e
https://doi.org/10.1002/jlcr.3896
https://doi.org/10.1002/jlcr.3896
Autor:
Idriss, Bennacef, Daniel, Rubins, Kerry, Riffel, Mangay, Williams, Diane J, Posavec, Marie A, Holahan, Mona L, Purcell, Hyking D, Haley, Mary, Wolf, Shawn J, Stachel, Laura S, Lubbers, Gregg A, Wesolowski, Le T, Duong, Terence G, Hamill, Jeffrey L, Evelhoch, Eric D, Hostetler
Publikováno v:
Journal of labelled compoundsradiopharmaceuticalsREFERENCES. 64(4)
The cathepsin K (CatK) enzyme is abundantly expressed in osteoclasts, and CatK inhibitors have been developed for the treatment of osteoporosis. In our effort to support discovery and clinical evaluations of a CatK inhibitor, we sought to discover a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bdb02b926f3faa356b518eec36f58133
https://pubmed.ncbi.nlm.nih.gov/33226657
https://pubmed.ncbi.nlm.nih.gov/33226657
Autor:
Le T. Duong, Helmut Glantschnig, Steven S. Carroll, Danielle H. Euler, Yangsi Ou, T. Cusick, Gregg Wesolowski, Laura S. Lubbers, Bin Luo, Bennett Ma
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 390:435-441
The correlation of in vitro inhibition of cathepsin K (CatK) activity and in vivo suppression of collagen I biomarkers was examined with three selective CatK inhibitors to explore the potential translatability from animal species to human. These inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a43588a2817694abf32dc4689f4782b6
https://doi.org/10.1007/s00210-017-1356-5
https://doi.org/10.1007/s00210-017-1356-5
Autor:
Keith Wessner, Gary Adamson, Bin Luo, Helmut Glantschnig, Traci Q. Lifsted, Laura S. Lubbers, Bennett Ma, G Wesolowski
Publikováno v:
Journal of Circulating Biomarkers
Journal of Circulating Biomarkers, Vol 8 (2019)
Journal of Circulating Biomarkers, Vol 8 (2019)
Cathepsin K (CatK) inhibitors exhibited chondroprotective and pain-reducing effects in animal models, however, improvements were relatively modest at dose levels achieving maximal suppression of CatK biomarkers in urine. In this report, a previously
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb256c555b3209c3bb04d7f06b4bb8db
https://pubmed.ncbi.nlm.nih.gov/30671145
https://pubmed.ncbi.nlm.nih.gov/30671145
Autor:
Soheil Ghafurian, Colena Johnson, Belma Dogdas, Laura S. Lubbers, Ansuman Bagchi, Maria S. Michener, Christopher T. Winkelmann, John J. Renger, Catherine D. G. Hines, Jason M. Uslaner, Antong Chen, Tamara O. Montgomery, Ashleigh Bone, Hatim A. Zariwala
Publikováno v:
Medical Imaging: Image-Guided Procedures
Intracranial microdialysis is used for sampling neurochemicals and large peptides along with their metabolites from the interstitial fluid (ISF) of the brain. The ability to perform this in nonhuman primates (NHP) e.g., rhesus could improve the predi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb386d07db92fe3f604630b294ba69c7
https://doi.org/10.1117/12.2217539
https://doi.org/10.1117/12.2217539
Autor:
John J. Renger, Jason M. Uslaner, Soheil Ghafurian, Colena Johnson, Belma Dogdas, Stacey O'Malley, Hatim A. Zariwala, Laura S. Lubbers, Kenneth Lodge, Catherine D. G. Hines, Ashleigh Bone, Ansuman Bagchi, Christopher T. Winkelmann, Antong Chen
Publikováno v:
Medical Imaging: Image-Guided Procedures
Intracranial delivery of recombinant DNA and neurochemical analysis in nonhuman primate (NHP) requires precise targeting of various brain structures via imaging derived coordinates in stereotactic surgeries. To attain targeting precision, the surgica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c3ad26e32e46a9d2bd47ba571fd120de
https://doi.org/10.1117/12.2217534
https://doi.org/10.1117/12.2217534
Autor:
Anil Thankappan, Laura Sepp-Lorenzino, Andrea Matter, Vasant Jadhav, Tosha Shah, Jyoti Disa, Belma Dogdas, Walter Strapps, Marija Tadin-Strapps, Tayeba Khan, Hans Weber, Jillian DiMuzio, Laura S. Lubbers
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Short interfering RNAs (siRNAs) are a valuable tool for gene silencing with applications in both target validation and therapeutics. Many advances have recently been made to improve potency and specificity, and reduce toxicity and immunostimulation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a35236a138dff84ad422078733f39733