Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Laura S Caskey"'
Autor:
Jeran K Stratford, David J Bentrem, Judy M Anderson, Cheng Fan, Keith A Volmar, J S Marron, Elizabeth D Routh, Laura S Caskey, Jonathan C Samuel, Channing J Der, Leigh B Thorne, Benjamin F Calvo, Hong Jin Kim, Mark S Talamonti, Christine A Iacobuzio-Donahue, Michael A Hollingsworth, Charles M Perou, Jen Jen Yeh
Publikováno v:
PLoS Medicine, Vol 7, Iss 7, p e1000307 (2010)
Pancreatic ductal adenocarcinoma (PDAC) remains a lethal disease. For patients with localized PDAC, surgery is the best option, but with a median survival of less than 2 years and a difficult and prolonged postoperative course for most, there is an u
Externí odkaz:
https://doaj.org/article/8637234746224f3e9ffbe1636aaf9a1d
Autor:
Charlotte Story, H. Shelton Earp, Debra Hunter, Eric Ubil, Laura S. Caskey, Alisha Holtzhausen
Tyro3, Axl, Mer (TAM) receptor tyrosine kinases reduce inflammatory, innate immune responses. We demonstrate that tumor-secreted protein S (Pros1), a Mer/Tyro3 ligand, decreased macrophage M1 cytokine expression in vitro and in vivo. In contrast, tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33877fbbaf320381a7881649e7550d2a
https://europepmc.org/articles/PMC5983338/
https://europepmc.org/articles/PMC5983338/
Autor:
Allison M. Deal, Stephen A. Bernard, Richard M. Goldberg, Albert S. Baldwin, Hong Jin Kim, Laura S. Caskey, Fred A. Wright, Benjamin F. Calvo, Michael O. Meyers, Bert H. O'Neil, Joel E. Tepper, William K. Funkhouser
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 80:705-711
Purpose Rectal cancer is often clinically resistant to radiotherapy (RT) and identifying molecular markers to define the biologic basis for this phenomenon would be valuable. The nuclear factor κ-light chain-enhancer of activated B cells (NF-κB) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ab1a79b9ff7180e2387dca92edcc030
https://doi.org/10.1016/j.ijrobp.2010.02.063
https://doi.org/10.1016/j.ijrobp.2010.02.063
Autor:
Hong Zhou, Shu Mang Feng, Ruth Chen Dy, Laura S. Caskey, Debra Hunter, Xihui Yang, H. Shelton Earp, Rebecca S. Muraoka-Cook, Carolyn I. Sartor
Publikováno v:
Molecular Endocrinology. 21:1861-1876
Unlike the proliferative action of other epidermal growth factor (EGF) receptor family members, HER4/ErbB4 is often associated with growth-inhibitory and differentiation signaling. These actions may involve HER4 two-step proteolytic processing by int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0c8059122b724316ae3c6ade300ed1
https://doi.org/10.1210/me.2006-0101
https://doi.org/10.1210/me.2006-0101
Autor:
Evelyn Kawata, H. Shelton Earp, Katherine Guttridge, Stephen P. Ethier, Nancy E. Hynes, Benjamin F. Calvo, Ewa Kozlowska, Jennifer Harrelson, Carolyn I. Sartor, Laura S. Caskey, Hong Zhou
Publikováno v:
Molecular and Cellular Biology. 21:4265-4275
The function of the epidermal growth factor receptor (EGFR) family member HER4 remains unclear because its activating ligand, heregulin, results in either proliferation or differentiation. This variable response may stem from the range of signals gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffd8fcb67ce84585b279c6a04201a89
https://doi.org/10.1128/mcb.21.13.4265-4275.2001
https://doi.org/10.1128/mcb.21.13.4265-4275.2001
Publikováno v:
Biochemical and Biophysical Research Communications. 251:688-692
NEDD8 is a novel ubiquitin-like protein that has been shown to conjugate to nuclear proteins in a manner analogous to ubiquitination and sentrinization. To identify proteins that are involved in the NEDD8-conjugation and de-conjugation pathway, the y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73c8a5e09bfbc1b9aacde20a039f66ca
https://doi.org/10.1006/bbrc.1998.9532
https://doi.org/10.1006/bbrc.1998.9532
Publikováno v:
Journal of Biological Chemistry. 272:28198-28201
Sentrin is a ubiquitin-like molecule that has been shown to interact with the death domains of Fas and tumor necrosis factor receptor 1 (TNFR1), PML, Rad51, Rad52, and RanGAP1. We have reported previously that sentrin can be conjugated to other prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb7f42e757d554dd4017093ba4f20bf
https://doi.org/10.1074/jbc.272.45.28198
https://doi.org/10.1074/jbc.272.45.28198
Publikováno v:
Microbiology. 142:1739-1747
A periplasmic arginine transport system that is a member of the ATP -dependent transport superfamily was identified in Pasteurella haemolytica. The gene encoding the periplasmic binding protein (lapT) was cloned and the protein overexpressed in Esche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ceb7d19bc7d337c6266a4104b706a3c0
https://doi.org/10.1099/13500872-142-7-1739
https://doi.org/10.1099/13500872-142-7-1739
Autor:
Hanna K. Sanoff, Anastasia Ivanova, Hong Jin Kim, Richard M. Goldberg, Stephen A. Bernard, Laura Raftery, Paul E. Wise, Benjamin F. Calvo, Laura S. Caskey, Michael O. Myers, Emily Chan, Bert H. O'Neil, Joel E. Tepper, A. Bapsi Chakravarthy
Standard therapy for stage II/III rectal cancer consists of a fluoropyrimidine and radiation therapy followed by surgery. Preclinical data demonstrated that bortezomib functions as a radiosensitizer in colorectal cancer models. The purpose of this st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f22df31d853d920cbdde044ef81b098a
Autor:
Rebecca S. Muraoka-Cook, Azeddine Atfi, Melissa Sandahl, Debra Hunter, H. Shelton Earp, Shu Mang Feng, Laura S. Caskey, Keiji Miyazawa
In general, epidermal growth factor receptor family members stimulate cell proliferation. In contrast, at least one HER4 isoform, JM-a/Cyt1, inhibits cell growth after undergoing a two-step proteolytic cleavage that first produces a membrane-anchored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36b5b9d5d9cb459862a44ba21851b832
https://europepmc.org/articles/PMC2630679/
https://europepmc.org/articles/PMC2630679/