Zobrazeno 1 - 10
of 208
pro vyhledávání: '"Laura S, Schmidt"'
Autor:
Christopher J. Ricketts, Aguirre A. De Cubas, Huihui Fan, Christof C. Smith, Martin Lang, Ed Reznik, Reanne Bowlby, Ewan A. Gibb, Rehan Akbani, Rameen Beroukhim, Donald P. Bottaro, Toni K. Choueiri, Richard A. Gibbs, Andrew K. Godwin, Scott Haake, A. Ari Hakimi, Elizabeth P. Henske, James J. Hsieh, Thai H. Ho, Rupa S. Kanchi, Bhavani Krishnan, David J. Kwiatkowski, Wenbin Liu, Maria J. Merino, Gordon B. Mills, Jerome Myers, Michael L. Nickerson, Victor E. Reuter, Laura S. Schmidt, C. Simon Shelley, Hui Shen, Brian Shuch, Sabina Signoretti, Ramaprasad Srinivasan, Pheroze Tamboli, George Thomas, Benjamin G. Vincent, Cathy D. Vocke, David A. Wheeler, Lixing Yang, William Y. Kim, A. Gordon Robertson, Paul T. Spellman, W. Kimryn Rathmell, W. Marston Linehan
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 113063- (2024)
Externí odkaz:
https://doaj.org/article/53d6204d634d4e3487233c292d61e7e8
Autor:
Martin Lang, Laura S. Schmidt, Kelli M. Wilson, Christopher J. Ricketts, Carole Sourbier, Cathy D. Vocke, Darmood Wei, Daniel R. Crooks, Youfeng Yang, Benjamin K. Gibbs, Xiaohu Zhang, Carleen Klumpp-Thomas, Lu Chen, Rajarshi Guha, Marc Ferrer, Crystal McKnight, Zina Itkin, Darawalee Wangsa, Danny Wangsa, Amy James, Simone Difilippantonio, Baktir Karim, Francisco Morís, Thomas Ried, Maria J. Merino, Ramaprasad Srinivasan, Craig J. Thomas, W. Marston Linehan
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 42, Iss 1, Pp 1-14 (2023)
Abstract Background MiT-Renal Cell Carcinoma (RCC) is characterized by genomic translocations involving microphthalmia-associated transcription factor (MiT) family members TFE3, TFEB, or MITF. MiT-RCC represents a specific subtype of sporadic RCC tha
Externí odkaz:
https://doaj.org/article/6b0458681f774fc788c19d8f3ed9c6d2
Autor:
Chiara Di Malta, Angela Zampelli, Letizia Granieri, Claudia Vilardo, Rossella De Cegli, Laura Cinque, Edoardo Nusco, Salvatore Pece, Daniela Tosoni, Francesca Sanguedolce, Nicolina Cristina Sorrentino, Maria J Merino, Deborah Nielsen, Ramaprasad Srinivasan, Mark W Ball, Christopher J Ricketts, Cathy D Vocke, Martin Lang, Baktiar Karim, Luisa Lanfrancone, Laura S Schmidt, W Marston Linehan, Andrea Ballabio
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 5, Pp 1-12 (2023)
Abstract Birt‐Hogg‐Dubé (BHD) syndrome is an inherited familial cancer syndrome characterized by the development of cutaneous lesions, pulmonary cysts, renal tumors and cysts and caused by loss‐of‐function pathogenic variants in the gene enc
Externí odkaz:
https://doaj.org/article/fc7292bb504a4e85bf4c9b3aa30dc3e3
Autor:
Ryosuke Jikuya, Todd A. Johnson, Kazuhiro Maejima, Jisong An, Young-Seok Ju, Hwajin Lee, Kyungsik Ha, WooJeung Song, Youngwook Kim, Yuki Okawa, Shota Sasagawa, Yuki Kanazashi, Masashi Fujita, Seiya Imoto, Taku Mitome, Shinji Ohtake, Go Noguchi, Sachi Kawaura, Yasuhiro Iribe, Kota Aomori, Tomoyuki Tatenuma, Mitsuru Komeya, Hiroki Ito, Yusuke Ito, Kentaro Muraoka, Mitsuko Furuya, Ikuma Kato, Satoshi Fujii, Haruka Hamanoue, Tomohiko Tamura, Masaya Baba, Toshio Suda, Tatsuhiko Kodama, Kazuhide Makiyama, Masahiro Yao, Brian M. Shuch, Christopher J. Ricketts, Laura S. Schmidt, W. Marston Linehan, Hidewaki Nakagawa, Hisashi Hasumi
Publikováno v:
EBioMedicine, Vol 92, Iss , Pp 104596- (2023)
Summary: Background: Birt-Hogg-Dubé (BHD) syndrome, caused by germline alteration of folliculin (FLCN) gene, develops hybrid oncocytic/chromophobe tumour (HOCT) and chromophobe renal cell carcinoma (ChRCC), whereas sporadic ChRCC does not harbor FLC
Externí odkaz:
https://doaj.org/article/1a1f190403a54532b17c7529b2ef813d
Autor:
Ryosuke Jikuya, Koichi Murakami, Akira Nishiyama, Ikuma Kato, Mitsuko Furuya, Jun Nakabayashi, Jordan A. Ramilowski, Haruka Hamanoue, Kazuhiro Maejima, Masashi Fujita, Taku Mitome, Shinji Ohtake, Go Noguchi, Sachi Kawaura, Hisakazu Odaka, Takashi Kawahara, Mitsuru Komeya, Risa Shinoki, Daiki Ueno, Hiroki Ito, Yusuke Ito, Kentaro Muraoka, Narihiko Hayashi, Keiichi Kondo, Noboru Nakaigawa, Koji Hatano, Masaya Baba, Toshio Suda, Tatsuhiko Kodama, Satoshi Fujii, Kazuhide Makiyama, Masahiro Yao, Brian M. Shuch, Laura S. Schmidt, W. Marston Linehan, Hidewaki Nakagawa, Tomohiko Tamura, Hisashi Hasumi
Publikováno v:
iScience, Vol 25, Iss 6, Pp 104463- (2022)
Summary: Our understanding of how each hereditary kidney cancer adapts to its tissue microenvironment is incomplete. Here, we present single-cell transcriptomes of 108,342 cells from patient specimens including from six hereditary kidney cancers. The
Externí odkaz:
https://doaj.org/article/b3b92f19eaba434889b74457863fa6ce
Autor:
Mitsuhiro Endoh, Masaya Baba, Tamie Endoh, Akiyoshi Hirayama, Ayako Nakamura-Ishizu, Terumasa Umemoto, Michihiro Hashimoto, Kunio Nagashima, Tomoyoshi Soga, Martin Lang, Laura S. Schmidt, W. Marston Linehan, Toshio Suda
Publikováno v:
Cell Reports, Vol 30, Iss 6, Pp 1823-1834.e5 (2020)
Summary: The tumor suppressor folliculin (FLCN) suppresses nuclear translocation of TFE3, a master transcription factor for lysosomal biogenesis, via regulation of amino-acid-sensing Rag GTPases. However, the importance of this lysosomal regulation i
Externí odkaz:
https://doaj.org/article/3b9e850e1d30466c9177e85db8779dca
Autor:
Jillian L, Chen, David T, Miller, Laura S, Schmidt, David, Malkin, Bruce R, Korf, Charis, Eng, David J, Kwiatkowski, Krinio, Giannikou
Publikováno v:
Annual Review of Genomics and Human Genetics. 23:331-361
A mosaic state arises when pathogenic variants are acquired in certain cell lineages during postzygotic development, and mosaic individuals may present with a generalized or localized phenotype. Here, we review the current state of knowledge regardin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77a03daf094c624cc84e692d2729f8d7
https://doi.org/10.1146/annurev-genom-120121-105450
https://doi.org/10.1146/annurev-genom-120121-105450
Autor:
Rebecca A. Sager, Mark R. Woodford, Sarah J. Backe, Alan M. Makedon, Alexander J. Baker-Williams, Bryanna T. DiGregorio, David R. Loiselle, Timothy A. Haystead, Natasha E. Zachara, Chrisostomos Prodromou, Dimitra Bourboulia, Laura S. Schmidt, W. Marston Linehan, Gennady Bratslavsky, Mehdi Mollapour
Publikováno v:
Cell Reports, Vol 26, Iss 5, Pp 1344-1356.e5 (2019)
Summary: The molecular chaperone Hsp90 stabilizes and activates client proteins. Co-chaperones and post-translational modifications tightly regulate Hsp90 function and consequently lead to activation of clients. However, it is unclear whether this pr
Externí odkaz:
https://doaj.org/article/de66c6bb8ecb4bfabba4d27f34f19f26
Autor:
James Brugarolas, W. Marston Linehan, Charis Eng, Patricia L.M. Dahia, Xian-Jin Xie, Chao Xing, Adam R. Metwalli, Maria J. Merino, Nick Grishin, Lisa Kinch, Lindsay Middelton, James Peterson, Christopher J. Ricketts, Cathy D. Vocke, Alana Christie, Andrea Pavia-Jimenez, Samuel Peña-Llopis, Jessica L. Mester, Laura S. Schmidt, Megan N. Farley
PDF file - 233K, VHL mutation status in some but not all tumors from Family NCI-1326.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1a107592d76de15555689e3e2f1575
https://doi.org/10.1158/1541-7786.22509765
https://doi.org/10.1158/1541-7786.22509765
Autor:
W. Marston Linehan, Laura S. Schmidt, Yuichi Oike, Toshio Suda, Tomomi Kamba, Masahiro Yao, Masatoshi Eto, Kimi Araki, Naoto Kuroda, Yoji Nagashima, Masafumi Oyama, Koshiro Nishimoto, Ryoma Kurahashi, Aiko Sugiyama, Yukiko Hasumi, Luh Ade Wilan Krisna, Joseph D. Kalen, Lilia Ileva, Baktiar O. Karim, Nicole Morris, Yorifumi Satou, Tsuyoshi Kadomatsu, Ikuma Kato, Ying Huang, Hisashi Hasumi, Hong-Wei Sun, Wenjuan Ma, Shintaro Funasaki, Martin Lang, Takanobu Motoshima, Mitsuko Furuya, Masaya Baba
Figure legends for Supplemental Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48123514222750546b2fc61506a3b817
https://doi.org/10.1158/1541-7786.22512951
https://doi.org/10.1158/1541-7786.22512951