Nitric oxide-induced ribosome collision activates ribosomal surveillance mechanisms

Autor: Laura Ryder, Frederic Schrøder Arendrup, José Francisco Martínez, Goda Snieckute, Chiara Pecorari, Riyaz Ahmad Shah, Anders H. Lund, Melanie Blasius, Simon Bekker-Jensen

Publikováno v: Cell Death and Disease, Vol 14, Iss 7, Pp 1-10 (2023)

Abstract Impairment of protein translation can cause stalling and collision of ribosomes and is a signal for the activation of ribosomal surveillance and rescue pathways. Despite clear evidence that ribosome collision occurs stochastically at a cellu

Externí odkaz: https://doaj.org/article/f8cffef743ee4b129b054cb825d27f9d

Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response

Autor: Goda Snieckute, Aitana Victoria Genzor, Anna Constance Vind, Laura Ryder, Mark Stoneley, Sébastien Chamois, René Dreos, Cathrine Nordgaard, Frederike Sass, Melanie Blasius, Aida Rodríguez López, Sólveig Hlín Brynjólfsdóttir, Kasper Langebjerg Andersen, Anne E. Willis, Lisa B. Frankel, Steen Seier Poulsen, David Gatfield, Zachary Gerhart-Hines, Christoffer Clemmensen, Simon Bekker-Jensen

Publikováno v: Cell Metabolism
Cell metabolism, vol. 34, no. 12, pp. 2036-2046.e8
Snieckute, G, Genzor, A V, Vind, A C, Ryder, L, Stoneley, M, Chamois, S, Dreos, R, Nordgaard, C, Sass, F, Blasius, M, López, A R, Brynjólfsdóttir, S H, Andersen, K L, Willis, A E, Frankel, L B, Poulsen, S S, Gatfield, D, Gerhart-Hines, Z, Clemmensen, C & Bekker-Jensen, S 2022, ' Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response ', Cell Metabolism, vol. 34, no. 12, pp. 2036-2046.e8 . https://doi.org/10.1016/j.cmet.2022.10.011

Impairment of translation can lead to collisions of ribosomes, which constitute an activation platform for several ribosomal stress-surveillance pathways. Among these is the ribotoxic stress response (RSR), where ribosomal sensing by the MAP3K ZAKα

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3d0569649abd95832585e8b3d41f58