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pro vyhledávání: '"Laura Rolinger"'
Publikováno v:
Analytical and Bioanalytical Chemistry, 415 (5), 841–854
Monitoring the protein concentration and buffer composition during the Ultrafiltration/Diafiltration (UF/DF) step enables the further automation of biopharmaceutical production and supports Real-time Release Testing (RTRT). Previously, in-line Ultrav
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03b45a9fb881ad3fba84c42c2297545
Autor:
Jürgen Hubbuch, Juliane Diehm, Laura Rolinger, Jessica Chow-Hubbertz, Martin Heitmann, Matthias Rüdt, Stefan Schleper
Publikováno v:
Analytical and Bioanalytical Chemistry. 412:2123-2136
Ultrafiltration/diafiltration (UF/DF) plays an important role in the manufacturing of biopharmaceuticals. Monitoring critical process parameters and quality attributes by process analytical technology (PAT) during those steps can facilitate process d
Publikováno v:
Biotechnology and Bioengineering, 118 (11), 4255-4268
A promising application of Process Analytical Technology to the downstream process of monoclonal antibodies (mAbs) is the monitoring of the Protein A load phase as its control promises economic benefits. Different spectroscopic techniques have been e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f2c7f5438d266abad64163a99220089
https://publikationen.bibliothek.kit.edu/1000137046
https://publikationen.bibliothek.kit.edu/1000137046
Publikováno v:
Biotechnology & bioengineering, 118 (2), 905-917
Real‐time monitoring and control of protein A capture steps by process analytical technologies (PATs) promises significant economic benefits due to the improved usage of the column's binding capacity, by eliminating time‐consuming off‐line anal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b886acecfb0df3e562b453a32a7a6d
Publikováno v:
Analytical and bioanalytical chemistry, 412 (9), 2047–2064
Analytical and Bioanalytical Chemistry
Analytical and Bioanalytical Chemistry
As competition in the biopharmaceutical market gets keener due to the market entry of biosimilars, process analytical technologies (PATs) play an important role for process automation and cost reduction. This article will give a general overview and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37164ce21c2b3f45850e4797555d27b9
Publikováno v:
Biotechnology and Bioengineering
Biotechnology & bioengineering, 114 (2), 368-373
Biotechnology & bioengineering, 114 (2), 368-373
The load phase in preparative Protein A capture steps is commonly not controlled in real‐time. The load volume is generally based on an offline quantification of the monoclonal antibody (mAb) prior to loading and on a conservative column capacity d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b30df4c7a8e601e0552a562d597e968b