Growth arrest-specific transcript 5 associated snoRNA levels are related to p53 expression and DNA damage in colorectal cancer.

Autor: Jonathan Krell, Adam E Frampton, Reza Mirnezami, Victoria Harding, Alex De Giorgio, Laura Roca Alonso, Patrizia Cohen, Silvia Ottaviani, Teresa Colombo, Jimmy Jacob, Loredana Pellegrino, Gordon Buchanan, Justin Stebbing, Leandro Castellano

Publikováno v: PLoS ONE, Vol 9, Iss 6, p e98561 (2014)

The growth arrest-specific transcript 5 gene (GAS5) encodes a long noncoding RNA (lncRNA) and hosts a number of small nucleolar RNAs (snoRNAs) that have recently been implicated in multiple cellular processes and cancer. Here, we investigate the rela

Externí odkaz: https://doaj.org/article/094b2e8918844274bb9bea8614ffa18f

Supplementary Tables 1 through 6 from Downregulation of microRNA-515-5p by the Estrogen Receptor Modulates Sphingosine Kinase 1 and Breast Cancer Cell Proliferation

Autor: Leandro Castellano, Dmitry Pchejetski, Justin Stebbing, Jonathan Waxman, Victoria Harding, Alexander de Giorgio, Laura Roca-Alonso, Loredana Pellegrino, Jimmy Jacob, Heba Alshaker, Jonathan Krell, Joao Nunes, Adam E. Frampton, Filipa G. Pinho

PDF file, 150K, Table S1. Patient clinicopathological information (BC, breast cancer; IDC, invasive ductal carcinoma; IMC, invasive mixed carcinoma; ILC, invasive lobular carcinoma, ER, estrogen receptor; PgR, progesterone receptor; Her2, human epide

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::235c1ee38d48f582e7e766fd9976ea4f
https://doi.org/10.1158/0008-5472.22397279.v1

Supplementary Figure 3 from Downregulation of microRNA-515-5p by the Estrogen Receptor Modulates Sphingosine Kinase 1 and Breast Cancer Cell Proliferation

Autor: Leandro Castellano, Dmitry Pchejetski, Justin Stebbing, Jonathan Waxman, Victoria Harding, Alexander de Giorgio, Laura Roca-Alonso, Loredana Pellegrino, Jimmy Jacob, Heba Alshaker, Jonathan Krell, Joao Nunes, Adam E. Frampton, Filipa G. Pinho

PDF file, 7560K, Figure S3. SylArray enrichment analysis showing that the down-regulated genes upon miR-515-5p expression are enriched with miR-515-5p 'seeds'.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15676fb58c9070f51ea86724a71286c9
https://doi.org/10.1158/0008-5472.22397297.v1

Supplementary Figure 1 from Downregulation of microRNA-515-5p by the Estrogen Receptor Modulates Sphingosine Kinase 1 and Breast Cancer Cell Proliferation

Autor: Leandro Castellano, Dmitry Pchejetski, Justin Stebbing, Jonathan Waxman, Victoria Harding, Alexander de Giorgio, Laura Roca-Alonso, Loredana Pellegrino, Jimmy Jacob, Heba Alshaker, Jonathan Krell, Joao Nunes, Adam E. Frampton, Filipa G. Pinho

PDF file, 10214K, Figure S1. (A) miRNAs predicted to target SK1 3'UTR using TargetScan. miRNAs targeting SK1 3'UTR were predicted using the web-based software, TargetScan. The miRNAs highlighted were selected for further analysis and experiments. (B)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48d3b87fc605ab5f6ebef2abcf2446c0
https://doi.org/10.1158/0008-5472.22397303.v1

MicroRNAs Cooperatively Inhibit a Network of Tumor Suppressor Genes to Promote Pancreatic Tumor Growth and Progression

Autor: Laura Roca-Alonso, Long R. Jiao, Teresa Colombo, Leandro Castellano, Tamara Gall, Filipa G. Pinho, Jonathan Krell, Justin Stebbing, Loredana Pellegrino, Niccola Funel, David Britton, Elisa Giovannetti, Valerio Fulci, Adam E Frampton, Jimmy Jacob, Nagy A. Habib, Victoria Harding, Thomas Knösel, Raida Ahmad, Alexander de Giorgio, R. Charles Coombes

Publikováno v: Gastroenterology, 146(1), 268-277. W.B. Saunders Ltd
Frampton, A E, Castellano, L, Colombo, T, Giovannetti, E, Krell, J, Jacob, J, Pellegrino, L, Roca-Alonso, L, Funel, N, Gall, T M H, Giorgio, A, Pinho, F G, Fulci, V, Britton, D J, Ahmad, R, Habib, N A, Coombes, R C, Harding, V, Knosel, T, Stebbing, J & Jiao, L R 2014, ' MicroRNAs Cooperatively Inhibit a Network of Tumor Suppressor Genes to Promote Pancreatic Tumor Growth and Progression ', Gastroenterology, vol. 146, no. 1, pp. 268-277 . https://doi.org/10.1053/j.gastro.2013.10.010

Background & Aims There has not been a broad analysis of the combined effects of altered activities of microRNAs (miRNAs) in pancreatic ductal adenocarcinoma (PDAC) cells, and it is unclear how these might affect tumor progression or patient outcomes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d54ca096efd80d3e566f3370afd810e
https://doi.org/10.1053/j.gastro.2013.10.010