Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Laura Robaldo"'
Autor:
Rodrigo Pontiggia, Santiago Di Lella, Darío A. Estrin, Javier M. Montserrat, Adolfo M. Iribarren, Joachim W. Engels, Laura Robaldo
Publikováno v:
The Journal of Physical Chemistry B. 117:57-69
The hybridization performance of a set of 12-mer RNA:RNA duplexes containing 2'-C-methyluridine, 5-bromo-2'-C-methyluridine, or (2'S)-2'-deoxy-2'-C-methyluridine was analyzed. Melting point temperatures of the modified duplexes showed an important Δ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78d789eb98e9719c431848e250d901c2
https://doi.org/10.1021/jp3081645
https://doi.org/10.1021/jp3081645
Autor:
Franco Izzo, María Andrea Dellafiore, Laura Robaldo, Javier M. Montserrat, Patricia V. Elizalde, Adolfo M. Iribarren, Cecilia J. Proietti
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:2581-2586
The catalytic core of a 10-23 DNAzyme was modified introducing conformationally restricted nucleosides such as (2'R)-, (2'S)-2'-deoxy-2'-C-methyluridine, (2'R)-, (2'S)-2'-deoxy-2'-C-methylcytidine, 2,2'-anhydrouridine and LNA-C, in one, two or three
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61b6786138615968988c0f2b4c03fb9b
https://doi.org/10.1016/j.bmc.2012.02.047
https://doi.org/10.1016/j.bmc.2012.02.047
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
The highly conserved untranslated regions of the hepatitis C virus (HCV) play a fundamental role in viral translation and replication and are therefore attractive targets for drug development. A set of modified DNAzymes carrying (2¿R)-, (2¿S)-2¿-d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b153821cbcf9bc477a5a86f3ba312dc1
https://pubmed.ncbi.nlm.nih.gov/25079672
https://pubmed.ncbi.nlm.nih.gov/25079672
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(15)
The catalytic core of a 10-23 DNAzyme was modified using (2′ R ), (2′ S )-2′-deoxy-2′- C -methyluridine and LNA-T. Catalytic activities under pseudo first order conditions were compared at different Mg 2+ concentrations, indicating that certa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8afcdf236515ef646489e78adc8a870
https://pubmed.ncbi.nlm.nih.gov/20615701
https://pubmed.ncbi.nlm.nih.gov/20615701
Publikováno v:
Scopus-Elsevier
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
DNAzymes and Ribozymes find applications as inhibitors of gene expression and in detection systems such as biosensors, among others. In particular, we are interested in the properties of hammerhead ribozymes carrying 2′-C-methylnucleotides and 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17cda633705d0d316beb8ffeb4b0caf
http://www.scopus.com/inward/record.url?eid=2-s2.0-78649398129&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-78649398129&partnerID=MN8TOARS
Publikováno v:
ChemMedChem; Sep2014, Vol. 9 Issue 9, p2172-2177, 6p