Supplementary Figure S2 from Targeted Exome Sequencing of Krebs Cycle Genes Reveals Candidate Cancer–Predisposing Mutations in Pheochromocytomas and Paragangliomas

Autor: Alberto Cascón, Mercedes Robledo, Graeme Eisenhofer, Jorgina Satrústegui, Manel Esteller, Sebastian Moran, Lorena Maestre, Scherezade Jiménez, Emiliano Honrado, Rafael Torres-Pérez, Antonio Galarreta, Rocío Letón, Guillermo Pita, María Currás-Freixes, Laura Contreras, Susan Richter, Iñaki Comino-Méndez, Laura Remacha

(A) GOT2 western blot of HeLa cells stably silenced for GOT2 expression by shRNA transfection compared to non-silenced scrambled (Scr) control cells. β-actin was used as a loading control. (B) Number of GOT2 KD HeLa cells after transfection with emp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08b90cd8afdd8bbe93155ae3e62b7102
https://doi.org/10.1158/1078-0432.22463502.v1

Supplementary Figure S4 from Targeted Exome Sequencing of Krebs Cycle Genes Reveals Candidate Cancer–Predisposing Mutations in Pheochromocytomas and Paragangliomas

Autor: Alberto Cascón, Mercedes Robledo, Graeme Eisenhofer, Jorgina Satrústegui, Manel Esteller, Sebastian Moran, Lorena Maestre, Scherezade Jiménez, Emiliano Honrado, Rafael Torres-Pérez, Antonio Galarreta, Rocío Letón, Guillermo Pita, María Currás-Freixes, Laura Contreras, Susan Richter, Iñaki Comino-Méndez, Laura Remacha

DNA methylation (M-values) of the CpG island probes located within six PCC/PGL susceptibility genes encoding Krebs cycle enzymes (SDHA, SDHAF2, SDHB, SDHD, FH, and MDH2) in the 11 analyzed tumors, compared to in vitro methylated DNA (IVD).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288499189d8d4b9499a892b17c00a5b9
https://doi.org/10.1158/1078-0432.22463496.v1

Supplementary Figure Legends from Targeted Exome Sequencing of Krebs Cycle Genes Reveals Candidate Cancer–Predisposing Mutations in Pheochromocytomas and Paragangliomas

Autor: Alberto Cascón, Mercedes Robledo, Graeme Eisenhofer, Jorgina Satrústegui, Manel Esteller, Sebastian Moran, Lorena Maestre, Scherezade Jiménez, Emiliano Honrado, Rafael Torres-Pérez, Antonio Galarreta, Rocío Letón, Guillermo Pita, María Currás-Freixes, Laura Contreras, Susan Richter, Iñaki Comino-Méndez, Laura Remacha

Legends of the Supplementary Figures

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f2396b3dc61f5ff1932172270f84d7b
https://doi.org/10.1158/1078-0432.22463508.v1

Data from Targeted Exome Sequencing of Krebs Cycle Genes Reveals Candidate Cancer–Predisposing Mutations in Pheochromocytomas and Paragangliomas

Autor: Alberto Cascón, Mercedes Robledo, Graeme Eisenhofer, Jorgina Satrústegui, Manel Esteller, Sebastian Moran, Lorena Maestre, Scherezade Jiménez, Emiliano Honrado, Rafael Torres-Pérez, Antonio Galarreta, Rocío Letón, Guillermo Pita, María Currás-Freixes, Laura Contreras, Susan Richter, Iñaki Comino-Méndez, Laura Remacha

Purpose: Mutations in Krebs cycle genes are frequently found in patients with pheochromocytomas/paragangliomas. Disruption of SDH, FH or MDH2 enzymatic activities lead to accumulation of specific metabolites, which give rise to epigenetic changes in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ff82b4b4e311b0bdcde2d724f003d6
https://doi.org/10.1158/1078-0432.c.6525420

Integrative multi-omics analysis identifies a prognostic miRNA signature and a targetable miR-21-3p/TSC2/mTOR axis in metastatic pheochromocytoma/paraganglioma

Autor: Judith Favier, Felix Beuschlein, Graeme Eisenhofer, Maria Currás-Freixes, Laurence Amar, Laura Remacha, Letizia Canu, Fabio L. Fernandes-Rosa, Anne-Paule Gimenez-Roqueplo, Ángel M Martínez-Montes, Fatima Al-Shahrour, Henri J L M Timmers, Cristina Montero-Conde, Bruna Calsina, Rafael Torres-Pérez, Rocío Letón, Elena Rapizzi, Jacques W.M. Lenders, Alfonso Cordero-Barreal, Julia Sastre-Marcos, Alexandre Bellucci, Maria José Santos, María Calatayud, Cristina Álvarez-Escolá, Javier Aller, Aguirre A. de Cubas, Esther Korpershoek, Lucía Inglada-Pérez, Veronika Mancikova, Nelly Burnichon, Cristina Rodríguez-Antona, Martin Fassnacht-Capeller, Massimo Mannelli, Alberto Cascón, Charlotte Lussey-Lepoutre, Javier Lanillos, Mercedes Robledo, Luis Jaime Castro-Vega, Osvaldo Graña, Cristina Lamas, Juan María Roldan-Romero

Publikováno v: Theranostics
Theranostics, 9, 17, pp. 4946-4958
Theranostics, 9(17), 4946-4958. Ivyspring International Publisher
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Repisalud
Instituto de Salud Carlos III (ISCIII)
Theranostics, 9, 4946-4958

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar y los autores pertenecientes a la UAM
Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine tumors that present variable outco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65914c862c6f868cf8b1678d8fe9432d
https://hdl.handle.net/2066/208812