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Autor:
Judith Baker, Dennis J. Stone, Mary Lou Lubin, Raymond W. Colburn, Mark A. Youngman, Matthews Jay M, Mike Hawkins, Christopher M. Flores, Tasha Hutchinson, Laura Reany, Mcnally James J, Michael P. Neeper, Yi Liu, Ning Qin, Michael R. Brandt, Scott L. Dax
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(8)
A series of benzothiophene-based phosphonates was synthesized and many analogs within the series were shown to be potent antagonists of the TRPM8 channel. The compounds were obtained as a racemic mixture in 5 synthetic steps, and were tested for TRPM