Dynamic release of neuronal extracellular vesicles containing miR‐21a‐5p is induced by hypoxia

Autor: Nea Korvenlaita, Mireia Gómez‐Budia, Flavia Scoyni, Cristiana Pistono, Luca Giudice, Shaila Eamen, Sanna Loppi, Ana Hernández deSande, Benjamin Huremagic, Maria Bouvy‐Liivrand, Merja Heinäniemi, Minna U. Kaikkonen, Lesley Cheng, Andrew F. Hill, Katja M. Kanninen, Guido W. Jenster, Martin E. vanRoyen, Laura Ramiro, Joan Montaner, Tereza Batkova, Robert Mikulik, Rosalba Giugno, Jukka Jolkkonen, Paula Korhonen, Tarja Malm

Publikováno v: Journal of Extracellular Vesicles, Vol 12, Iss 1, Pp n/a-n/a (2023)

Abstract Hypoxia induces changes in the secretion of extracellular vesicles (EVs) in several non‐neuronal cells and pathological conditions. EVs are packed with biomolecules, such as microRNA(miR)‐21‐5p, which respond to hypoxia. However, the t

Externí odkaz: https://doaj.org/article/094e282ac7ab43019b81d3777335442b

Inflammatory molecules might become both biomarkers and therapeutic targets for stroke management

Autor: Laura Ramiro, Alba Simats, Teresa García-Berrocoso, Joan Montaner

Publikováno v: Therapeutic Advances in Neurological Disorders, Vol 11 (2018)

Stroke is the fifth leading cause of death and the most frequent cause of disability worldwide. Currently, stroke diagnosis is based on neuroimaging; therefore, the lack of a rapid tool to diagnose stroke is still a major concern. In addition, therap

Externí odkaz: https://doaj.org/article/1550ebcd274a424097c8afac12e13ca6

Diet Supplementation with Polyphenol-Rich

Autor: Paula, García-Rodríguez, Feifei, Ma, Carmen Del, Río, Marina, Romero-Bernal, Ana M, Najar, María de la Luz, Cádiz-Gurrea, Francisco Javier, Leyva-Jimenez, Laura, Ramiro, Paloma, Menéndez-Valladares, Soledad, Pérez-Sánchez, Antonio, Segura-Carretero, Joan, Montaner

Publikováno v: Nutrients. 14(23)

Strokes are the second most common cause of death worldwide and a leading cause of disability. Regular consumption of polyphenols has been shown to reduce the risk of suffering a cardiovascular event. For this reason, we have investigated the protect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0fddbc7533a88c8a7c4d47e9de3436c2
https://pubmed.ncbi.nlm.nih.gov/36501107

Role of Blood-Based Biomarkers in Ischemic Stroke Prognosis

Autor: Alejandro Bustamante, Peter U. Heuschmann, Laura Ramiro, William Whiteley, Joan Montaner, Felipe A. Montellano, Felix Fluri, Simon Hellwig, Aliona Nacu, Kathrin Ungethüm

Publikováno v: Montellano, F A, Ungethüm, K, Ramiro, L, Nacu, A, Hellwig, S, Fluri, F, Whiteley, W N, Bustamante, A, Montaner, J & Heuschmann, P U 2021, ' Role of Blood-Based Biomarkers in Ischemic Stroke Prognosis : A Systematic Review ', Stroke . https://doi.org/10.1161/STROKEAHA.120.029232

Background and Purpose: Outcome prognostication in ischemic stroke patients remains challenging due to limited predictive properties of existing models. Blood-based biomarkers might provide additional information to established prognostic factors. We

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cde5d0e23df78da7bc3741423157313
https://doi.org/10.1161/strokeaha.120.029232

Ceruletide and Alpha-1 Antitrypsin as a Novel Combination Therapy for Ischemic Stroke

Autor: Alba Simats, Laura Ramiro, Raquel Valls, Helena de Ramón, Paula García-Rodríguez, Cyrille Orset, Laura Artigas, Teresa Sardon, Anna Rosell, Joan Montaner

Publikováno v: Neurotherapeutics

Ischemic stroke is a primary cause of morbidity and mortality worldwide. Beyond the approved thrombolytic therapies, there is no effective treatment to mitigate its progression. Drug repositioning combinational therapies are becoming promising approa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d056b246f550b2d11165e9e41ff8890c
http://hdl.handle.net/10261/304074