Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Laura R Fitzgerald"'
Autor:
Andrea Arendse, Tracy Stevenson, Tyzoon K. Nomanbhoy, Marya Liimatta, Jessica P. Alexander, Douglas S. Johnson, Laura R Fitzgerald, Kyunghye Ahn, Richard A. Nugent, Benjamin F. Cravatt, Eric T Lund
Publikováno v:
Biochemistry. 46:13019-13030
Fatty acid amide hydrolase (FAAH) is an integral membrane enzyme that degrades the fatty acid amide family of signaling lipids, including the endocannabinoid anandamide. Genetic or pharmacological inactivation of FAAH leads to analgesic, anti-inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad909ffb5b6b153db3de6df04798ba43
https://doi.org/10.1021/bi701378g
https://doi.org/10.1021/bi701378g
Autor:
Jon K. Chambers, Laura R. Fitzgerald, Shelagh Wilson, Philip G. Szekeres, Nabil Elshourbagy, Usman Shabon, Dulcie B. Schmidt, George M. Dytko, Nicholas A. Evans, Derk J. Bergsma, Robert S. Ames, Kong B. Tan, Henry M. Sarau, Da Yuan Wang, Graeme Milligan, D. Alex Groarke, Peter T. Buckley, Paul R. Murdock, James J. Foley, Parvathi Nuthulaganti
Publikováno v:
Journal of Biological Chemistry. 275:25965-25971
Opiate tolerance and dependence are major clinical and social problems. The anti-opiate neuropeptides FF and AF (NPFF and NPAF) have been implicated in pain modulation as well as in opioid tolerance and may play a critical role in this process, altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd5cafd790b16038f625a65339c455f1
https://doi.org/10.1074/jbc.m004515200
https://doi.org/10.1074/jbc.m004515200
Autor:
Jessica E. Reed, Laura R. Fitzgerald
Publisher Summary Melatonin is widely used as an over-the-counter therapy for the treatment of sleep disorders. This chapter discusses the use of melatonin and synthetic melatonin agonists for the treatment of sleep, major depression and anxiety. The
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed84afff4d1b794fc43f43519c6a0ec1
https://doi.org/10.1016/s0065-7743(04)39003-2
https://doi.org/10.1016/s0065-7743(04)39003-2
Autor:
Christopher W. Benjamin, Laura R. Fitzgerald, Kathleen A. Schellin, Jerry Slightom, Steven L. Roberds, Alla M. Karnovsky, Denise D. McKinley, Julie L. Piechan, Cara L. Ruble, Cynthia J. Mills, Lisa F. Gotow
Publikováno v:
Gene. 319
The ligand-gated ion channel family includes receptors for serotonin (5-hydroxytryptamine, 5-HT), acetylcholine, GABA, and glutamate. Drugs targeting subtypes of these receptors have proven useful for the treatment of various neuropsychiatric and neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f433f69e24c1f85472675698d54a2bd
https://pubmed.ncbi.nlm.nih.gov/14597179
https://pubmed.ncbi.nlm.nih.gov/14597179
Autor:
Catherine E. Ellis, Nabil Elshourbagy, Pamela Lane, Laura R. Fitzgerald, Shelagh Wilson, Ping Tsui, Derk J. Bergsma, Robert S. Ames, Kong B. Tan, Henry M. Sarau, Ishrat Jahan Mannan, G. Dytko, Nicholas D. Evans, David A. Campbell, Lynnette McMillan, Heather Minehart, Paul R. Murdock, James J. Foley
Publikováno v:
Biochemical and biophysical research communications. 273(3)
We have identified a cDNA, designated HOFNH30, which encodes a 354 amino acid G-protein-coupled receptor (GPCR). This receptor has 96% amino acid identity to the Jurkat-T cell-derived EDG7 and could be a splice variant. RT-PCR analysis demonstrated t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0e566edd62e3ee7ee839673f724410
https://pubmed.ncbi.nlm.nih.gov/10891327
https://pubmed.ncbi.nlm.nih.gov/10891327
Autor:
Nabil Elshourbagy, Jeffrey L. Mooney, Mcmillan Lynette Jane, Hsiao-Ling Wu, Sharon Butler, Angela M. Smith, Laura R. Fitzgerald, Shelagh Wilson, Philip G. Szekeres, Derk J. Bergsma, Jane Miller, Gillian I. Rennie, Alison I. Muir, Lisa D. Spinage, Stephanie E. Guerrera, Jon K. Chambers, Lisa Vawter, Paul R. Murdock
Publikováno v:
The Journal of biological chemistry. 275(27)
Neuromedins are a family of peptides best known for their contractile activity on smooth muscle preparations. The biological mechanism of action of neuromedin U remains unknown, despite the fact that the peptide was first isolated in 1985. Here we sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b50352840720622422e05ab40d94f1f
https://pubmed.ncbi.nlm.nih.gov/10811630
https://pubmed.ncbi.nlm.nih.gov/10811630
Publikováno v:
Analytical biochemistry. 275(1)
We have established a rapid, sensitive, high-throughput assay that requires one assay condition to detect agonist effects from Gi-, Gs-, and Gq-coupled receptors. We utilized a vector containing a promoter with three multiple response elements, the v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f26002027c7d3e6ad206ad935c549c3e
https://pubmed.ncbi.nlm.nih.gov/10542109
https://pubmed.ncbi.nlm.nih.gov/10542109
Autor:
Bella Osak, Laura R. Fitzgerald
Publikováno v:
Assay & Drug Development Technologies; Dec2007, Vol. 5 Issue 6, p785-792, 8p