Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Laura R Erker"'
Autor:
Maria A. Parker, Laura R. Erker, Isabelle Audo, Dongseok Choi, Saddek Mohand-Said, Kastytis Sestakauskas, Patrick Benoit, Terence Appelqvist, Melissa Krahmer, Caroline Ségaut-Prévost, Brandon J. Lujan, Ambar Faridi, Elvira N. Chegarnov, Peter N. Steinkamp, Cristy Ku, Mariana Matioli da Palma, Pierre-Olivier Barale, Sarah Ayelo-Scheer, Andreas Lauer, Tim Stout, David J. Wilson, Richard G. Weleber, Mark E. Pennesi, José Alain Sahel, Paul Yang
Publikováno v:
Am J Ophthalmol
PURPOSE: To report on the safety of the first five cohorts of a gene therapy trial using recombinant equine infectious anemia virus expressing ABCA4 (EIAV-ABCA4) in adults with Stargardt Dystrophy (SD) due to mutations in ABCA4. DESIGN: Nonrandomized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea46289d9bb8c140ffe8c9b8f6ea8180
https://europepmc.org/articles/PMC9308722/
https://europepmc.org/articles/PMC9308722/
Autor:
Christine N. Kay, Laura R Erker, Todd Durham, Sina Farsiu, Wendi Liang, Glenn J. Jaffe, David G. Birch, Frederick L. Ferris, Michel Michaelides, Maureen G. Maguire, José-Alain Sahel, Isabelle Audo, Jacque L. Duncan, Mark E. Pennesi, Simona Degli Esposti, Elise Héon, Allison R Ayala, Joseph Carroll, Robert B. Hufnagel, Alessandro Iannaccone, Janet K. Cheetham
Publikováno v:
Am J Ophthalmol
Purpose To report baseline visual fields in the Rate of Progression in USH2A-related Retinal Degeneration (RUSH2A) study. Design Cross-sectional study within a natural history study. Methods Setting: multicenter, international. Study population: Ushe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b9b3c3c8ad8cf9a108a73de497abf05
https://pubmed.ncbi.nlm.nih.gov/32446738
https://pubmed.ncbi.nlm.nih.gov/32446738
REPEATABILITY AND LONGITUDINAL ASSESSMENT OF FOVEAL CONE STRUCTURE IN CNGB3-ASSOCIATED ACHROMATOPSIA
Autor:
Maria Parker, William W. Hauswirth, Moataz M Razeen, Phyllis Summerfelt, Christine N. Kay, Joseph Carroll, Jeffrey D. Chulay, Laura R Erker, Alfredo Dubra, Brian P. Higgins, Paul Yang, Gerald A. Fishman, Byron L. Lam, David J. Wilson, Jing Zhang, Mark E. Pennesi, Frederick T Collison, Christopher S Langlo, Richard G. Weleber, Emily J. Patterson
Publikováno v:
Retina (Philadelphia, Pa.)
High-resolution in vivo imaging has provided evidence of residual cone structure in congenital achromatopsia, although the progressive nature of the disease remains unclear. In this study, the authors use optical coherence tomography and adaptive opt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af235d238ffbf6579dc1d386b5fa53fd
http://europepmc.org/articles/PMC5537050
http://europepmc.org/articles/PMC5537050
Autor:
Albert Romo, Peter N. Steinkamp, Laura R Erker, Travis B. Smith, Ning Smith, Maria Parker, Brandon J. Lujan
Publikováno v:
Translational Vision Science & Technology
Purpose We investigate the ellipsoid zone (EZ) area and EZ boundary shape measurement reliability and the operability characteristics of two methods of EZ boundary delineation in spectral-domain optical coherence tomography (SD-OCT). Methods EZ bound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5ea453c73ba63b9cac750152d2ef15
https://pubmed.ncbi.nlm.nih.gov/31211002
https://pubmed.ncbi.nlm.nih.gov/31211002
Autor:
Laura R Erker, David J. Wilson, Catherine L. Schlechter, Paul Yang, Claire Marie Dhaenens, Isabelle Audo, Peter N. Steinkamp, Jose A. Sahel, Saddek Mohand-Said, Maria Parker, Dongseok Choi, Mark E. Pennesi, Richard G. Weleber, Elvira N. Chegarnov
Publikováno v:
Translational Vision Science & Technology
Purpose The goal of this analysis was to determine the test-retest variability of functional and structural measures from a cohort of patients with advanced forms of Stargardt Disease (STGD) participating in the SAR422459 (NCT01367444) gene therapy c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a535e649ed29fa27ad34efe7c82a8232
http://europepmc.org/articles/PMC5054761
http://europepmc.org/articles/PMC5054761
Autor:
Markus Grompe, Laura R Erker, Olga Smirnova, Jonathan Schug, Pamela S. Canaday, Maike Sander, Andrew W. Duncan, Janel L. Kopp, Alan J. Fox, Craig Dorrell, Milton J. Finegold, Klaus H. Kaestner
Publikováno v:
Genes & Development. 25:1193-1203
The molecular identification of adult hepatic stem/progenitor cells has been hampered by the lack of truly specific markers. To isolate putative adult liver progenitor cells, we used cell surface-marking antibodies, including MIC1-1C3, to isolate sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4da05ae3dd6bc980cc065ec228d9a3b3
https://doi.org/10.1101/gad.2029411
https://doi.org/10.1101/gad.2029411
Autor:
Alessandro Iannacone, Laura R Erker, Dianna K. Hughbanks-Wheaton, Stephen Rose, Steven Bramer, Paul Yang, Thiran Jayasundera, Michael Teske, Jennifer McCormack, Patricia Zilliox, Richard G. Weleber, Karl G. Csaky, Byron L. Lam, Paul S. Bernstein, Judith E. A. Warner, Robert Lindblad, John R. Heckenlively, Travis B. Smith, Mary Elizabeth Hartnett, Gary E. Fish, Neal L. Sklaver, Peter J. Francis, David G. Birch, Kevin L. Winthrop, Aimee Wahle, Mark E. Pennesi, Paul C. VanVeldhuisen, Elvira N. Chegarnov
Publikováno v:
JAMA Ophthalmology. 136:849
Importance There are no approved drug treatments for autosomal dominant retinitis pigmentosa, a relentlessly progressive cause of adult and childhood blindness. Objectives To evaluate the potential efficacy and assess the safety of orally administere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd6a102e0edda6e9f334b44b787228d
https://doi.org/10.1001/jamaophthalmol.2018.1171
https://doi.org/10.1001/jamaophthalmol.2018.1171
Autor:
Laura R Erker, Simon Weonsang Ro, Pamela S. Canaday, Stephanie L. Abraham, Kelsea M. Lanxon-Cookson, Philip R. Streeter, Markus Grompe, Tristan Victoroff, Craig Dorrell
Publikováno v:
Hepatology. 48:1282-1291
The biology of progenitor activation in the liver is of considerable medical and scientific interest. The powerful genetic tools available for the mouse make it an ideal model system to study this complex process involving many different cell types.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::368b61dc013bd9a8208cbc0542c4839b
https://doi.org/10.1002/hep.22468
https://doi.org/10.1002/hep.22468
Autor:
Laura R Erker, Markus Grompe
Publikováno v:
Stem Cell Research. 1(2):90-102
Oval cells are hypothesized to be the progeny of intrahepatic stem cells, also referred to as adult liver stem cells. The mechanisms by which these cells are activated to proliferate and differentiate during liver regeneration is important for the de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45c0ad80b4787d614ee30d3271022a97
Autor:
Roberto Calcedo, Laura R Erker, William W. Hauswirth, Jeffrey D. Chulay, Margaret Humphries, Mark E. Pennesi, Lauren Jensen, David J. Wilson, J. Timothy Stout, Terence R. Flotte, Richard G. Weleber, Maureen T. McBride, Shalesh Kaushal
Publikováno v:
Ophthalmology. 123(7)
Purpose To provide an initial assessment of the safety of a recombinant adeno-associated virus vector expressing RPE65 (rAAV2-CB-hRPE65) in adults and children with retinal degeneration caused by RPE65 mutations. Design Nonrandomized, multicenter cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a83139e2ae8405cdc7d24026085973
https://pubmed.ncbi.nlm.nih.gov/27102010
https://pubmed.ncbi.nlm.nih.gov/27102010