Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Laura Perna"'
Autor:
Kira Trares, Manuel Wiesenfarth, Hannah Stocker, Laura Perna, Agnese Petrera, Stefanie M. Hauck, Konrad Beyreuther, Hermann Brenner, Ben Schöttker
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-12 (2024)
Abstract Background It is of interest whether inflammatory biomarkers can improve dementia prediction models, such as the widely used Cardiovascular Risk Factors, Aging and Dementia (CAIDE) model. Methods The Olink Target 96 Inflammation panel was as
Externí odkaz:
https://doaj.org/article/3313fd7b8403475fa5a95d2a1c0a25d6
Autor:
Laura Perna, Hannah Stocker, Lena Burow, Léon Beyer, Kira Trares, Carolin Kurz, Selim Gürsel, Bernd Holleczek, Maia Tatò, Konrad Beyreuther, Ute Mons, Klaus Gerwert, Robert Perneczky, Ben Schöttker, Hermann Brenner
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-12 (2023)
Abstract Background Subjective cognitive complaints (SCC) have been mostly studied in the context of Alzheimer’s disease in memory clinic settings. The potential of combining SCC with genetic information and blood biomarkers of neurodegenerative di
Externí odkaz:
https://doaj.org/article/8ca4f10d01674786a34aa01b7d7f0079
Autor:
Laura Perna
Publikováno v:
Journal of Postsecondary Student Success, Vol 3, Iss 2 (2024)
As in other nations, higher education has many benefits for individual participants and for communities in the United States. But, the opportunity to attain higher education is unequal. To understand the forces that contribute to higher education att
Externí odkaz:
https://doaj.org/article/22f0b050596f48fd93b8dbfe0703423f
Autor:
Hannah Stocker, Kira Trares, Léon Beyer, Laura Perna, Dan Rujescu, Bernd Holleczek, Konrad Beyreuther, Klaus Gerwert, Ben Schöttker, Hermann Brenner
Publikováno v:
Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-9 (2023)
Abstract Background In order to utilize polygenic risk scores (PRSs) for Alzheimer’s disease (AD) in a meaningful way, influential factors (i.e. training set) and prediction across groups such as APOE e4 (APOE4) genotype as well as associations to
Externí odkaz:
https://doaj.org/article/6bebce118115470eb721c902d18273b7
Autor:
Kira Trares, Megha Bhardwaj, Laura Perna, Hannah Stocker, Agnese Petrera, Stefanie M. Hauck, Konrad Beyreuther, Hermann Brenner, Ben Schöttker
Publikováno v:
Alzheimer’s Research & Therapy, Vol 14, Iss 1, Pp 1-17 (2022)
Abstract Background Chronic inflammation is a central feature of several forms of dementia. However, few details on the associations of blood-based inflammation-related proteins with dementia incidence have been explored yet. Methods The Olink Target
Externí odkaz:
https://doaj.org/article/a4badd12af52490da2fdd286cf7f6c8c
Autor:
Fabian Streit, Maja P. Völker, Johanna Klinger-König, Lea Zillich, Josef Frank, Iris Reinhard, Jerome C. Foo, Stephanie H. Witt, Lea Sirignano, Heiko Becher, Nadia Obi, Oliver Riedel, Stefanie Do, Stefanie Castell, Max J. Hassenstein, André Karch, Andreas Stang, Börge Schmidt, Tamara Schikowski, Anna Stahl-Pehe, Hermann Brenner, Laura Perna, Karin Halina Greiser, Rudolf Kaaks, Karin B. Michels, Claus-Werner Franzke, Annette Peters, Beate Fischer, Julian Konzok, Rafael Mikolajczyk, Amand Führer, Thomas Keil, Julia Fricke, Stefan N. Willich, Tobias Pischon, Henry Völzke, Claudia Meinke-Franze, Markus Loeffler, Kerstin Wirkner, Klaus Berger, Hans J. Grabe, Marcella Rietschel
Publikováno v:
Frontiers in Epidemiology, Vol 3 (2023)
IntroductionFamily history of depression and childhood maltreatment are established risk factors for depression. However, how these factors are interrelated and jointly influence depression risk is not well understood. The present study investigated
Externí odkaz:
https://doaj.org/article/485bc99437d74bd98b84c5765111cbfb
Publikováno v:
BMC Geriatrics, Vol 22, Iss 1, Pp 1-9 (2022)
Abstract Background A large body of evidence supports a link between type 2 diabetes mellitus (T2DM) and cognitive function, including dementia. However, longitudinal studies on the association between T2DM and decline of cognitive function are scarc
Externí odkaz:
https://doaj.org/article/f1d27a3caac748678d6522c13637bb08
Autor:
Laura Perna, Matteo Castelli, Elena Frasnetti, Lisa E. L. Romano, Giorgio Colombo, Chrisostomos Prodromou, J. Paul Chapple
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2023)
The ataxia-linked protein sacsin has three regions of partial homology to Hsp90’s N-terminal ATP binding domain. Although a crystal structure for this Hsp90-like domain has been reported the precise molecular interactions required for ATP-binding a
Externí odkaz:
https://doaj.org/article/c0aa50ba1f2b4c8ca612da0b4630692c
Autor:
Tobias Möllers, Hannah Stocker, Laura Perna, Andreas Nabers, Dan Rujescu, Annette M. Hartmann, Bernd Holleczek, Ben Schöttker, Klaus Gerwert, Hermann Brenner
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-9 (2021)
Abstract Background To understand the potential for early intervention and prevention measures in Alzheimer’s disease, the association between risk factors and early pathological change needs to be assessed. Hence, the aim of this study was to dete
Externí odkaz:
https://doaj.org/article/0efa01ca22154ee3b34212fead340022
Autor:
Hannah Stocker, Andreas Nabers, Laura Perna, Tobias Möllers, Dan Rujescu, Annette M. Hartmann, Bernd Holleczek, Ben Schöttker, Julia Stockmann, Klaus Gerwert, Hermann Brenner
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Alzheimer’s disease is highly heritable and characterized by amyloid plaques and tau tangles in the brain. The aim of this study was to investigate the association between genetic predisposition, Aβ misfolding in blood plasma, a unique ma
Externí odkaz:
https://doaj.org/article/984ebc39339c484e8fbc41bf5cc52ec5