Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Laura Pedraza"'
Autor:
Dhanushan Wijayaratna, Filippo Sacchetta, Laura Pedraza-González, Francesca Fanelli, Tomohiro Sugihara, Mitsumasa Koyanagi, Senuri Piyawardana, Kiran Ghotra, Waruna Thotamune, Akihisa Terakita, Massimo Olivucci, Ajith Karunarathne
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-22 (2024)
Abstract Melanopsin is a photopigment belonging to the G Protein-Coupled Receptor (GPCR) family expressed in a subset of intrinsically photosensitive retinal ganglion cells (ipRGCs) and responsible for a variety of processes. The bistability and, thu
Externí odkaz:
https://doaj.org/article/a11bd4c5199c4714b627227aa9408a93
Autor:
Riccardo Palombo, Leonardo Barneschi, Laura Pedraza-González, Daniele Padula, Igor Schapiro, Massimo Olivucci
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Fluorescent proteins that self-assemble and localize in the neuron membrane are vital in neurosciences, particularly in optogenetics applications. Here the authors present a quantum-mechanics/molecular mechanics model for the photoisomerization of th
Externí odkaz:
https://doaj.org/article/5cab5006ee1845d488073dd0ad41392a
Autor:
Leonardo Barneschi, Emanuele Marsili, Laura Pedraza-González, Daniele Padula, Luca De Vico, Danil Kaliakin, Alejandro Blanco-González, Nicolas Ferré, Miquel Huix-Rotllant, Michael Filatov, Massimo Olivucci
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Arch-3 rhodopsin variants are common fluorescent reporters of neuronal activity. Here, the authors show with quantum chemical modelling that a set of these proteins reveals a direct proportionality between their observed fluorescence intensity and th
Externí odkaz:
https://doaj.org/article/8db7a882c81c4841b40e3170f489ada1
Autor:
Yuta Nakajima, Laura Pedraza-González, Leonardo Barneschi, Keiichi Inoue, Massimo Olivucci, Hideki Kandori
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Nakajima, Pedraza-González et al. provide a comprehensive investigation of amino acid mutations at position 219 of the sodium pump rhodopsin, KR2, and their role in the color tuning of the retinal chromophore. They prepared P219X (X= A, C, D, E, F,
Externí odkaz:
https://doaj.org/article/67abff8fd4a744c1b2ba3f3c4c1967d9
Publikováno v:
Molecules, Vol 28, Iss 5, p 2333 (2023)
The appearance of a new coronavirus, SARS-CoV-2, in 2019 kicked off an international public health emergency. Although rapid progress in vaccination has reduced the number of deaths, the development of alternative treatments to overcome the disease i
Externí odkaz:
https://doaj.org/article/667d82b6de654445bc67cf725f83587b
Autor:
Laura Pedraza, Olga Laosa, Leocadio Rodríguez-Mañas, Diego F Gutiérrez-Romero, Jesús Frías, José Antonio Carnicero, Elena Ramírez
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
Background/aim: A prospective evaluation of drug-induced liver injury (DILI) in two tertiary hospitals was conducted through a pharmacovigilance program from laboratory signals at hospital (PPLSH) to determine the principal characteristics of DILI in
Externí odkaz:
https://doaj.org/article/26af3ab55e214658a74e7e2d592077cc
Autor:
Laura Pedraza-González, Leonardo Barneschi, Michał Marszałek, Daniele Padula, Luca De Vico, Massimo Olivucci
Publikováno v:
Journal of Chemical Theory and Computation. 19:293-310
We present a computational protocol for the fast and automated screening of excited-state hybrid quantum mechanics/molecular mechanics (QM/MM) models of rhodopsins to be used as fluorescent probes based on the automatic rhodopsin modeling protocol (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d082e7e4de9237f7108bdab005afce3
https://doi.org/10.1021/acs.jctc.2c00928
https://doi.org/10.1021/acs.jctc.2c00928
Autor:
Laura Pedraza-González, Edoardo Cignoni, Jacopo D’Ascenzi, Lorenzo Cupellini, Benedetta Mennucci
In response to varying light conditions, light-harvesting complexes (LHCs) switch from a light-harvesting to a quenched state to protect the photosynthetic organism from excessive light irradiation, in a strategy known as nonphotochemical quenching (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0f86b2bf3aa814bb8c14e8902cf9237
https://doi.org/10.26434/chemrxiv-2023-0k7g1
https://doi.org/10.26434/chemrxiv-2023-0k7g1
Autor:
Laura Pedraza-González, Leonardo Barneschi, Michał Marszałek, Daniele Padula, Luca De Vico, Massimo Olivucci
Source code of the PyARM package
Access to the developer's repository can be obtained by contacting the corresponding author. L.P.G, L.B., D.P., L.D.V. and M.O. acknowledge partial support provided by MUR (Ministero dell'Università e della Rice
Access to the developer's repository can be obtained by contacting the corresponding author. L.P.G, L.B., D.P., L.D.V. and M.O. acknowledge partial support provided by MUR (Ministero dell'Università e della Rice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd12c77a2a859d08395e3ef14ce73770
Autor:
Jorge Charry, Félix Moncada, Matteo Barborini, Laura Pedraza-González, Márcio T. do N. Varella, Alexandre Tkatchenko, Andrés Reyes
Computational studies have shown that one or more positrons can stabilize two repelling atomic anions through the formation of two-center positronic bonds. In the present work, we study the energetic stability of a system containing two positrons and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b769e2683742df48dff471b1acac864a
http://arxiv.org/abs/2208.09062
http://arxiv.org/abs/2208.09062