Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Laura Patrussi"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
T lymphocytes that infiltrate the tumor microenvironment (TME) often fail to function as effective anti-cancer agents. Within the TME, cell-to-cell inhibitory interactions play significant roles in dampening their anti-tumor activities. Recent studie
Externí odkaz:
https://doaj.org/article/196d4c4dcb614399ba338e50e5859c38
Autor:
Gioia Boncompagni, Vanessa Tatangelo, Ludovica Lopresti, Cristina Ulivieri, Nagaja Capitani, Carmela Tangredi, Francesca Finetti, Giuseppe Marotta, Federica Frezzato, Andrea Visentin, Sara Ciofini, Alessandro Gozzetti, Monica Bocchia, Diego Calzada-Fraile, Noa B. Martin Cofreces, Livio Trentin, Laura Patrussi, Cosima T. Baldari
Publikováno v:
Cell Death and Disease, Vol 15, Iss 2, Pp 1-13 (2024)
Abstract The tumor microenvironment (TME) plays a central role in the pathogenesis of chronic lymphocytic leukemia (CLL), contributing to disease progression and chemoresistance. Leukemic cells shape the TME into a pro-survival and immunosuppressive
Externí odkaz:
https://doaj.org/article/d642398d0f0d48b38f301e377350c763
Autor:
Sara Rossi, Vanessa Tatangelo, Maria Dichiara, Stefania Butini, Sandra Gemma, Simone Brogi, Silvia Pasquini, Martina Cappello, Fabrizio Vincenzi, Katia Varani, Ludovica Lopresti, Margherita Malchiodi, Chiara Carrara, Alessandro Gozzetti, Monica Bocchia, Giuseppe Marotta, Laura Patrussi, Gabriele Carullo, Cosima T. Baldari, Giuseppe Campiani
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 174, Iss , Pp 116537- (2024)
Chronic Lymphocytic Leukemia (CLL) patients have a defective expression of the proapoptotic protein p66Shc and of its transcriptional factor STAT4, which evoke molecular abnormalities, impairing apoptosis and worsening disease prognosis and severity.
Externí odkaz:
https://doaj.org/article/5b5fa73fa7a44b40b6f5ece58f9ee513
Autor:
Ludovica Lopresti, Nagaja Capitani, Vanessa Tatangelo, Carmela Tangredi, Gioia Boncompagni, Federica Frezzato, Andrea Visentin, Giuseppe Marotta, Sara Ciofini, Alessandro Gozzetti, Monica Bocchia, Livio Trentin, Cosima T. Baldari, Laura Patrussi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
Introduction: Escape from immunosurveillance is a hallmark of chronic lymphocytic leukemia (CLL) cells. In the protective niche of lymphoid organs, leukemic cells suppress the ability of T lymphocytes to form the immune synapse (IS), thereby hamperin
Externí odkaz:
https://doaj.org/article/e7e9e6a473054becbee4aeecfc465039
Autor:
Vanessa Tatangelo, Gioia Boncompagni, Nagaja Capitani, Ludovica Lopresti, Noemi Manganaro, Federica Frezzato, Andrea Visentin, Livio Trentin, Cosima T. Baldari, Laura Patrussi
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
The microenvironment of lymphoid organs is central to the pathogenesis of chronic lymphocytic leukemia (CLL). Within it, tumor cells find a favourable niche to escape immunosurveillance and acquire pro-survival signals. We have previously reported th
Externí odkaz:
https://doaj.org/article/a5a1f6b65d6b4a1ea89584dc82c6e24d
Autor:
Gioia Boncompagni, Alessia Varone, Vanessa Tatangelo, Nagaja Capitani, Federica Frezzato, Andrea Visentin, Livio Trentin, Daniela Corda, Cosima T. Baldari, Laura Patrussi
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
An imbalance in the expression of pro- and anti-apoptotic members of the Bcl-2 family of apoptosis-regulating proteins is one of the main biological features of CLL, highlighting these proteins as therapeutic targets for treatment of this malignancy.
Externí odkaz:
https://doaj.org/article/ecef887653664fcd9795e727d12332b6
Autor:
Leonardo Ermini, Maurizio Mandalà, Laura Cresti, Sofia Passaponti, Laura Patrussi, Luana Paulesu, Kent Thornburg, Francesca Ietta
Publikováno v:
Cells, Vol 11, Iss 20, p 3195 (2022)
Dietary exposure to Bisphenol A (BPA), an industrial chemical present in food containers, affects nutrient metabolism in the myocardium of offspring during intrauterine life. Using a murine model, we observed that fetal hearts from mothers exposed to
Externí odkaz:
https://doaj.org/article/41898c1e17974313921fec637df0c485
Autor:
Nagaja Capitani, Giulia Lori, Paolo Paoli, Laura Patrussi, Arianna Troilo, Cosima T. Baldari, Giovanni Raugei, Mario Milco D’Elios
Publikováno v:
Cancer Cell International, Vol 19, Iss 1, Pp 1-9 (2019)
Abstract Background Low molecular weight protein tyrosine phosphatase (LMW-PTP) is overexpressed in different cancer types and its expression is related to more aggressive disease, reduced survival rate and drug resistance. Morin is a natural polyphe
Externí odkaz:
https://doaj.org/article/2fa005b166fa4a7e8e0f106849b356c3
Autor:
Francesca Finetti, Nagaja Capitani, Noemi Manganaro, Vanessa Tatangelo, Francesca Libonati, Giulia Panattoni, Ivo Calaresu, Laura Ballerini, Cosima T. Baldari, Laura Patrussi
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
By preserving cell viability and three-dimensional localization, organotypic culture stands out among the newest frontiers of cell culture. It has been successfully employed for the study of diseases among which neoplasias, where tumoral cells take a
Externí odkaz:
https://doaj.org/article/2b433c885a91459f83940c0e93234e6d
Autor:
Laura Patrussi, Nagaja Capitani, Cristina Ulivieri, Noemi Manganaro, Massimo Granai, Francesca Cattaneo, Anna Kabanova, Lucia Mundo, Stefania Gobessi, Federica Frezzato, Andrea Visentin, Francesca Finetti, Pier Giuseppe Pelicci, Mario M. D’Elios, Livio Trentin, Gianpietro Semenzato, Lorenzo Leoncini, Dimitar G. Efremov, Cosima T. Baldari
Publikováno v:
Haematologica, Vol 104, Iss 10 (2019)
The Shc family adaptor p66Shc acts as a negative regulator of proliferative and survival signals triggered by the B-cell receptor and, by enhancing the production of reactive oxygen species, promotes oxidative stress-dependent apoptosis. Additionally
Externí odkaz:
https://doaj.org/article/6bc4cda3fc2a4cd2a79acd0bbd87ceab