Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Laura Pascual‐Reguant"'
Autor:
Laura Pascual‐Reguant, Queralt Serra‐Camprubí, Debayan Datta, Damiano Cianferoni, Savvas Kourtis, Antoni Gañez‐Zapater, Chiara Cannatá, Lorena Espinar, Jessica Querol, Laura García‐López, Sara Musa‐Afaneh, Maria Guirola, Anestis Gkanogiannis, Andrea Miró Canturri, Marta Guzman, Olga Rodríguez, Andrea Herencia‐Ropero, Joaquin Arribas, Violeta Serra, Luis Serrano, Tian V Tian, Sandra Peiró, Sara Sdelci
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp 1-23 (2023)
Abstract Triple‐negative breast cancer (TNBC) often develops resistance to single‐agent treatment, which can be circumvented using targeted combinatorial approaches. Here, we demonstrate that the simultaneous inhibition of LOXL2 and BRD4 synergis
Externí odkaz:
https://doaj.org/article/a9ac7e4ea8d342f3a90f379ec5eb682e
Autor:
Amandine Moretton, Savvas Kourtis, Antoni Gañez Zapater, Chiara Calabrò, Maria Lorena Espinar Calvo, Frédéric Fontaine, Evangelia Darai, Etna Abad Cortel, Samuel Block, Laura Pascual‐Reguant, Natalia Pardo‐Lorente, Ritobrata Ghose, Matthew G Vander Heiden, Ana Janic, André C Müller, Joanna I Loizou, Sara Sdelci
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 7, Pp 1-27 (2023)
Abstract While cellular metabolism impacts the DNA damage response, a systematic understanding of the metabolic requirements that are crucial for DNA damage repair has yet to be achieved. Here, we investigate the metabolic enzymes and processes that
Externí odkaz:
https://doaj.org/article/99959834b32e4fb5a1f4c0a860ce238d
Autor:
Ritobrata Ghose, Álvaro Aranguren-Ibáñez, Niccolò Arecco, Diego Balboa, Marc Bataller, Sergi Beltran, Hannah Benisty, Angèle Bénard, Edgar Bernardo, Sílvia Carbonell Sala, Eloi Casals, Ludovica Ciampi, Livia Condemi, Alberto Corvó, Marta Cosín-Tomás, Mirabai Cuenca-Ardura, Juan Manuel Duran Serrano, María Isabel Espejo Díaz, Marcos Fernandez Callejo, Antoni Gañez-Zapater, Raquel Garcia-Castellanos, Romina Garrido, Gil Henkin, Toni Hermoso Pulido, Xavier Hernandez-Alias, Jorge Herrero Vicente, Matthew Ingham, Wei Ming Lim, Sílvia Llonch, Elena Marmesat Bertoli, Irene Miguel-Escalada, Ariadna Montero-Blay, Cristina Navarrete Hernández, Maria Victoria Neguembor, Róisín-Ana Ní Chárthaigh, Natalia Pardo-Lorente, Laura Pascual-Reguant, Sílvia Pérez-Lluch, Reyes Perza, Martina Pesaresi, Daniel Picó Amador, Paula Pifarré, Davide Piscia, Marcos Plana-Carmona, Julia Ponomarenko, Leandro Radusky, Ezequiel Rivero, Malgorzata Rogalska, Guillem Torcal Garcia, José Wojnacki
Publikováno v:
F1000Research, Vol 9 (2020)
The COVID-19 pandemic has posed and is continuously posing enormous societal and health challenges worldwide. The research community has mobilized to develop novel projects to find a cure or a vaccine, as well as to contribute to mass testing, which
Externí odkaz:
https://doaj.org/article/a31f23efbb70401e91a65643d3267f89
Autor:
Laura Pascual-Reguant, Enrique Blanco, Silvia Galan, François Le Dily, Yasmina Cuartero, Gemma Serra-Bardenys, Valerio Di Carlo, Ane Iturbide, Joan Pau Cebrià-Costa, Lara Nonell, Antonio García de Herreros, Luciano Di Croce, Marc A. Marti-Renom, Sandra Peiró
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Lamina-associated domains (LADs) contact lamins in the nuclear lamina, and lamin B1 was thought to bind heterochromatic regions at the nuclear envelope. Here, the authors show lamin B1 associates with actively expressed euchromatin regions, creating
Externí odkaz:
https://doaj.org/article/78004395e63b43cd90af855de0989ca6
Autor:
Laura Pascual-Reguant, Tian V. Tian, Debayan Datta, Damiano Cianferoni, Savvas Kourtis, Antoni Gañez-Zapater, Chiara Cannatá, Queralt Serra-Camprubi, Lorena Espinar, Maria Guirola, Jessica Querol, Andrea Miró Canturri, Joaquin Arribas, Luis Serrano, Sandra Peiró, Sara Sdelci
Publikováno v:
Biorxiv.org (submitted to Cancer Reaserch)
bioRxiv
bioRxiv
Triple-negative breast cancer often develops resistance to single-agent treatments, which can be circumvented with targeted combinatorial approaches. Here, we demonstrate that the simultaneous inhibition of LOXL2 and BRD4 cooperate to reduce triple-n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98969a4dc6b42f91b8f7a8a652d043c5
Autor:
Sara Simonetti, Laura Pascual-Reguant, Vincente Peg, Beatriz Morancho, Cristina Viaplana, Josep Villanueva, Gaetano Verde, Cristina Saura, Marta Escorihuela, Sandra Peir oacute, Gemma Serra-Bardenys, Tian V. Tian, Joaqu iacuten Arribas, Rodrigo Dienstmann, Luciano Di Croce, Antonio Garc iacutea de Herreros, Paolo Nuciforo, Jessica Querol, Sandra Segura-Bayona, Alba Millanes-Romero, Enrique Blanco, Riccardo Aiese Cigliano, Travis H. Stracker, Celia Jer oacutenimo
SUMMARYThe histone modification of H3 oxidized at lysine 4 (H3K4ox) is catalyzed by lysyl oxidase–like 2 (LOXL2) and is enriched in heterochromatin in triple-negative breast cancer (TNBC) cells. Although H3K4ox has been linked to the maintenance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4270a391b2f0563a62dde16be7203e2
https://doi.org/10.1101/2020.01.30.927038
https://doi.org/10.1101/2020.01.30.927038
LOXL2-mediated H3K4 oxidation reduces chromatin accessibility in triple-negative breast cancer cells
Autor:
Gaetano Verde, Verónica Rodilla, David Andreu, Riccardo Aiese Cigliano, Ane Iturbide, Jessica Querol, Paolo Nuciforo, Walter Sanseverino, Joaquín Arribas, Travis H. Stracker, José Yélamos, M. Cosín, Sandra Segura-Bayona, Gemma Serra-Bardenys, Joan Pau Cebrià-Costa, Cristina Bernadó-Morales, Sandra Peiró, Abel Gonzalez-Perez, Laura Pascual-Reguant, A García de Herreros
Publikováno v:
Oncogene 39, 79-121 (2020)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Oncogene
Scientia
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Oncogene
Scientia
Cromosomes; Marcadors pronòstics Cromosomas; Marcadores de pronóstico Chromosomes; Prognostic markers Oxidation of H3 at lysine 4 (H3K4ox) by lysyl oxidase-like 2 (LOXL2) generates an H3 modification with an unknown physiological function. We find
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daabe112cd5499be77ca94ee16d69ec5
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=57955
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=57955
Autor:
Valerio Di Carlo, Marc A. Marti-Renom, Antonio García de Herreros, Lara Nonell, Gemma Serra-Bardenys, Laura Pascual-Reguant, Ane Iturbide, Joan Pau Cebrià-Costa, Enrique Blanco, Silvia Galan, Yasmina Cuartero, Sandra Peiró, Luciano Di Croce, François Le Dily
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Nature Communications
Recercat. Dipósit de la Recerca de Catalunya
instname
Nature Communications
Recercat. Dipósit de la Recerca de Catalunya
instname
Lamins (A/C and B) are major constituents of the nuclear lamina (NL). Structurally conserved lamina-associated domains (LADs) are formed by genomic regions that contact the NL. Lamins are also found in the nucleoplasm, with a yet unknown function. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208d6a4e9b396603bf144184a85f5e83
https://doaj.org/article/78004395e63b43cd90af855de0989ca6
https://doaj.org/article/78004395e63b43cd90af855de0989ca6
Autor:
Laura Pascual-Reguant, Ane Iturbide, Sandra Segura-Bayona, Gemma Serra-Bardenys, de Herreros Ag, Rodilla, Riccardo Aiese Cigliano, Abel Gonzalez-Perez, Walter Sanseverino, Paolo Nuciforo, Bernado-Morales C, Joaquín Arribas, Sandra Peiró, Jessica Querol, Verde G, Travis H. Stracker, Joan Pau Cebrià-Costa, José Yélamos, David Andreu, M. Cosín
Oxidation of H3 at lysine 4 (H3K4ox) by lysyl oxidase–like 2 (LOXL2) generates an H3 modification with an unknown physiological function. We find that LOXL2 and H3K4ox are higher in triple-negative breast cancer (TNBC) cell lines and patient–deri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::155d63d789bddf7314240c7450ac2e34
https://doi.org/10.1101/416495
https://doi.org/10.1101/416495
Autor:
Albert Jordan, Manel Esteller, Patricia Aribau-Miralbés, Anna Esteve-Codina, Matthew Murtha, Alberto Bustillos, Lluís Millán-Ariño, Laura Pascual-Reguant, Andrea Izquierdo-Bouldstridge, Daniel García-Gomis, Sandra Peiró, Carles Bonet-Costa, Marc Dabad
Publikováno v:
Dipòsit Digital de la UB
Universidad de Barcelona
Nucleic Acids Research
Recercat. Dipósit de la Recerca de Catalunya
instname
Digital.CSIC. Repositorio Institucional del CSIC
Universidad de Barcelona
Nucleic Acids Research
Recercat. Dipósit de la Recerca de Catalunya
instname
Digital.CSIC. Repositorio Institucional del CSIC
Histone H1 has seven variants in human somatic cells and contributes to chromatin compaction and transcriptional regulation. Knock-down (KD) of each H1 variant in breast cancer cells results in altered gene expression and proliferation differently in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::254564650b4e8ea6b590918f881a2c79
http://hdl.handle.net/2445/122088
http://hdl.handle.net/2445/122088