New chimeric TLR7/NOD2 agonist is a potent adjuvant to induce mucosal immune responses

Autor: Alice Gutjahr, Laura Papagno, Fabienne Vernejoul, Thierry Lioux, Fabienne Jospin, Blandine Chanut, Eric Perouzel, Nicolas Rochereau, Victor Appay, Bernard Verrier, Stéphane Paul

Publikováno v: EBioMedicine, Vol 58, Iss , Pp 102922- (2020)

Background: PRR (Pattern Recognition Receptor) agonists have been widely tested as potent vaccine adjuvants. TLR7 (Toll-Like Receptor 7) and NOD2 (nucleotide-binding oligomerization domain 2) are key innate receptors widely expressed at mucosal level

Externí odkaz: https://doaj.org/article/403a7afcebe344c591ff5fca6d3322a6

17 Priming of tumour or HIV-specific human CD8+ T cells with superior functional properties using STING ligands

Autor: Laura Papagno, Francesco Nicoli, Nozomi Kuse, Alice Gutjahr, Gerard Tiraby, Bernard Verrier, Stéphane Paul, Masafumi Takiguchi, Victor Appay

Publikováno v: Journal of Virus Eradication, Vol 3, Iss , Pp 12- (2017)

Externí odkaz: https://doaj.org/article/9661a344bb164b1ebcd8dcbcc93ab910

Immune activation and CD8+ T-cell differentiation towards senescence in HIV-1 infection.

Autor: Laura Papagno, Celsa A Spina, Arnaud Marchant, Mariolina Salio, Nathalie Rufer, Susan Little, Tao Dong, Gillian Chesney, Anele Waters, Philippa Easterbrook, P Rod Dunbar, Dawn Shepherd, Vincenzo Cerundolo, Vincent Emery, Paul Griffiths, Christopher Conlon, Andrew J McMichael, Douglas D Richman, Sarah L Rowland-Jones, Victor Appay

Publikováno v: PLoS Biology, Vol 2, Iss 2, p E20 (2004)

Progress in the fight against the HIV/AIDS epidemic is hindered by our failure to elucidate the precise reasons for the onset of immunodeficiency in HIV-1 infection. Increasing evidence suggests that elevated immune activation is associated with poor

Externí odkaz: https://doaj.org/article/9c5d9bfcd3b640d6b9963bb03ac78d0a

Altered Basal Lipid Metabolism Underlies the Functional Impairment of Naive CD8

Autor: Francesco, Nicoli, Mariela P, Cabral-Piccin, Laura, Papagno, Eleonora, Gallerani, Mathieu, Fusaro, Victor, Folcher, Marion, Dubois, Emmanuel, Clave, Hélène, Vallet, Justin J, Frere, Emma, Gostick, Sian, Llewellyn-Lacey, David A, Price, Antoine, Toubert, Loïc, Dupré, Jacques, Boddaert, Antonella, Caputo, Riccardo, Gavioli, Victor, Appay

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 208(3)

Aging is associated with functional deficits in the naive T cell compartment, which compromise the generation of de novo immune responses against previously unencountered Ags. The mechanisms that underlie this phenomenon have nonetheless remained unc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c492938c15f6db9ec2f869c5cb5c250e
https://pubmed.ncbi.nlm.nih.gov/35031578

Impact of IgA isoforms on their ability to activate dendritic cells and to prime T cells

Autor: Laura Papagno, Francesco Nicoli, Christophe Guillon, Rémi Gayet, Blandine Chanut, Zhiguo He, Nicolas Rochereau, Eva Michaud, Mireille Paul, Gilles Bioley, Blaise Corthésy, Stéphane Paul

Publikováno v: European Journal of Immunology
European Journal of Immunology, Wiley-VCH Verlag, 2020, 50 (9), pp.1295-1306. ⟨10.1002/eji.201948177⟩
European Journal of Immunology, 2020, 50 (9), pp.1295-1306. ⟨10.1002/eji.201948177⟩

Human IgA could be from different isotypes (IgA1/IgA2) and/or isoforms (monomeric, dimeric, or secretory). Monomeric IgA mainly IgA1 are considered as an anti-inflammatory isotype whereas dimeric/secretory IgA have clearly dual pro- and anti-inflamma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97d9bcaedafc111cff4e1d76ed067c0f
https://hal.archives-ouvertes.fr/hal-02990071