Zobrazeno 1 - 10
of 136
pro vyhledávání: '"Laura P. Stabile"'
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The influence of sex and body mass index (BMI) on the efficacy of immune checkpoint inhibitors (ICIs) in advanced non-small cell lung cancer (NSCLC) patients remains unclear. We conducted a retrospective study to evaluate the relationship be
Externí odkaz:
https://doaj.org/article/72939d3e536647c1b974a8e9d72c5507
Autor:
Madelyn Espinosa-Cotton, Elana J. Fertig, Laura P. Stabile, Autumn Gaither-Davis, Julie E. Bauman, Sandra Schmitz, Katherine N. Gibson-Corley, Yinwen Cheng, Isaac J. Jensen, Vladimir P. Badovinac, Douglas Laux, Andrean L. Simons
Publikováno v:
Biomarker Research, Vol 7, Iss 1, Pp 1-11 (2019)
Abstract Background The epidermal growth factor receptor (EGFR) monoclonal IgG1 antibody cetuximab is approved for first-line treatment of recurrent and metastatic (R/M) HNSCC as a part of the standard of care EXTREME regimen (platinum/5-fluorouracil
Externí odkaz:
https://doaj.org/article/7cb94e7905894534bb5933db154e06cd
Autor:
Mauricio S. Caetano, Maya Hassane, Hieu T. Van, Emmanuel Bugarin, Amber M. Cumpian, Christina L. McDowell, Carolina Gonzalez Cavazos, Huiyuan Zhang, Shanshan Deng, Lixia Diao, Jing Wang, Scott E. Evans, Carmen Behrens, Ignacio I. Wistuba, Susan A. W. Fuqua, Huang Lin, Laura P. Stabile, Stephanie S. Watowich, Humam Kadara, Seyed Javad Moghaddam
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Proinflammatory and immunomodulatory events that drive development of K-ras mutant lung adenocarcinoma (LUAD) are poorly understood. Here they develop a lung epithelial specific K-ras mutant/Stat3 conditional knockout mouse model and show a sex-speci
Externí odkaz:
https://doaj.org/article/a75e60d748374ccbaa270592719a5d9b
Autor:
Laura P. Stabile, Vinod Kumar, Autumn Gaither-Davis, Eric H. Huang, Frank P. Vendetti, Princey Devadassan, Sanja Dacic, Riyue Bao, Richard A. Steinman, Timothy F. Burns, Christopher J. Bakkenist
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Human lung adenocarcinoma (LUAD) in current or former smokers exhibits a high tumor mutational burden (TMB) and distinct mutational signatures. Syngeneic mouse models of clinically relevant smoking-related LUAD are lacking. We established and charact
Externí odkaz:
https://doaj.org/article/1954918282e2448aad0dedcd45e8477d
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
Lung cancer mortality represents the leading cause of cancer related deaths in the United States and worldwide. Almost half of these deaths occur in female patients, making lung cancer the most common cause of cancer mortality in women with a higher
Externí odkaz:
https://doaj.org/article/6926c1edd95d4d1894ac8ea390bac9ba
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 1, p 81 (2021)
High ERβ/HER oncogenic signaling defines lung tumors with an aggressive biology. We previously showed that combining the anti-estrogen fulvestrant with the pan-HER inhibitor dacomitinib reduced ER/HER crosstalk and produced synergistic anti-tumor ef
Externí odkaz:
https://doaj.org/article/da80a0b4cd974acb8ec0d8b488429d2f
Autor:
Jill M. Siegfried, Yan Lin, Brenda Diergaarde, Hui-Min Lin, Sanja Dacic, Arjun Pennathur, Joel L. Weissfeld, Marjorie Romkes, Tomoko Nukui, Laura P. Stabile
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 17, Iss 11, Pp 817-825 (2015)
Non–small cell lung cancers (NSCLCs) frequently express estrogen receptor (ER) β, and estrogen signaling is active in many lung tumors. We investigated the ability of genes contained in the prediction analysis of microarray 50 (PAM50) breast cance
Externí odkaz:
https://doaj.org/article/4377c323908a483c9a82498bb9b7b9d8
Autor:
Julie E. Bauman, James Ohr, William E. Gooding, Robert L. Ferris, Umamaheswar Duvvuri, Seungwon Kim, Jonas T. Johnson, Adam C. Soloff, Gerald Wallweber, John Winslow, Autumn Gaither-Davis, Jennifer R. Grandis, Laura P. Stabile
Publikováno v:
Cancers, Vol 12, Iss 6, p 1537 (2020)
Cetuximab, an anti-EGFR monoclonal antibody (mAb), is approved for advanced head and neck squamous cell carcinoma (HNSCC) but benefits a minority. An established tumor-intrinsic resistance mechanism is cross-talk between the EGFR and hepatocyte growt
Externí odkaz:
https://doaj.org/article/d37e10f337b84e2cae528e7cdd1a9bf0
Autor:
Autumn L. Gaither-Davis, Jill M. Siegfried, K. Jin Kim, Naftali Kaminski, Stephanie R. Land, Diana Lenzner, Phouthone Keohavong, Mary E. Rothstein, Laura P. Stabile
Publikováno v:
Cancers, Vol 2, Iss 4, Pp 2153-2170 (2010)
EGFR and c-Met are both overexpressed in lung cancer and initiate similar downstream signaling, which may be redundant. To determine how frequently ligands that initiate signaling of both pathways are found in lung cancer, we analyzed serum for hepat
Externí odkaz:
https://doaj.org/article/b04d1180c24846319e50dc55b8d1ab5b
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 2, p 611 (2018)
Estrogen receptors are broadly expressed in many cell types involved in the innate and adaptive immune responses, and differentially regulate the production of cytokines. While both genomic and non-genomic tumor cell promoting mechanisms of estrogen
Externí odkaz:
https://doaj.org/article/9155ae978b0b4a02badfcc97301fbfe1