Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Laura P. Mackay"'
Autor:
Stephen Muhi, Daniel P. O'Brien, Julia L. Marshall, Gayle Ross, Paul D.R. Johnson, Laura K. Mackay, Anand Ramakrishnan, James S. McCarthy, Marcel Doerflinger, Euzebiusz Jamrozik, Timothy P. Stinear, Joshua Osowicki
Publikováno v:
Wellcome Open Research, Vol 9 (2024)
Critical knowledge gaps have impeded progress towards reducing the global burden of disease due to Mycobacterium ulcerans, the cause of the neglected tropical disease Buruli ulcer (BU). Development of a controlled human infection model of BU has been
Externí odkaz:
https://doaj.org/article/c3b3819748b94938bdc0ba761aa200a3
Autor:
Isabelle Jia-Hui Foo, Brendon Y. Chua, E. Bridie Clemens, So Young Chang, Xiaoxiao Jia, Hayley A. McQuilten, Ashley Huey Yiing Yap, Aira F. Cabug, Mitra Ashayeripanah, Hamish E. G. McWilliam, Jose A. Villadangos, Maximilien Evrard, Laura K. Mackay, Linda M. Wakim, John K. Fazakerley, Katherine Kedzierska, Lukasz Kedzierski
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Immunity to infectious diseases is predominantly studied by measuring immune responses towards a single pathogen, although co-infections are common. In-depth mechanisms on how co-infections impact anti-viral immunity are lacking, but are hig
Externí odkaz:
https://doaj.org/article/f7573a9c40cb46eebac49bbe854be8df
Autor:
Stephen Muhi, Daniel P. O'Brien, Julia L. Marshall, Gayle Ross, Paul D.R. Johnson, Laura K. Mackay, Anand Ramakrishnan, James S. McCarthy, Marcel Doerflinger, Euzebiusz Jamrozik, Timothy P. Stinear, Joshua Osowicki
Publikováno v:
Wellcome Open Research, Vol 9 (2024)
Critical knowledge gaps have impeded progress towards reducing the global burden of disease due to Mycobacterium ulcerans, the cause of the neglected tropical disease Buruli ulcer (BU). Development of a controlled human infection model of BU has been
Externí odkaz:
https://doaj.org/article/edc943f8fc3e49d9b390671211b87caf
Autor:
Kevin E. Glinton, Charul Gijavanekar, Abbhirami Rajagopal, Laura P. Mackay, Kirt A. Martin, Phillip L. Pearl, K. Michael Gibson, Theresa A. Wilson, V. Reid Sutton, Sarah H. Elsea
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Genomic sequencing offers an untargeted, data-driven approach to genetic diagnosis; however, variants of uncertain significance often hinder the diagnostic process. The discovery of rare genomic variants without previously known functional evidence o
Externí odkaz:
https://doaj.org/article/29eec710b9ad4cdf9ea448935aba96f4
Autor:
Wuji Zhang, Brendon Y. Chua, Kevin J. Selva, Lukasz Kedzierski, Thomas M. Ashhurst, Ebene R. Haycroft, Suzanne K. Shoffner-Beck, Luca Hensen, David F. Boyd, Fiona James, Effie Mouhtouris, Jason C. Kwong, Kyra Y. L. Chua, George Drewett, Ana Copaescu, Julie E. Dobson, Louise C. Rowntree, Jennifer R. Habel, Lilith F. Allen, Hui-Fern Koay, Jessica A. Neil, Matthew J. Gartner, Christina Y. Lee, Patiyan Andersson, Sadid F. Khan, Luke Blakeway, Jessica Wisniewski, James H. McMahon, Erica E. Vine, Anthony L. Cunningham, Jennifer Audsley, Irani Thevarajan, Torsten Seemann, Norelle L. Sherry, Fatima Amanat, Florian Krammer, Sarah L. Londrigan, Linda M. Wakim, Nicholas J. C. King, Dale I. Godfrey, Laura K. Mackay, Paul G. Thomas, Suellen Nicholson, Kelly B. Arnold, Amy W. Chung, Natasha E. Holmes, Olivia C. Smibert, Jason A. Trubiano, Claire L. Gordon, Thi H. O. Nguyen, Katherine Kedzierska
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
The immune response to SARS-CoV-2 infection is variable but has been linked to prognosis and the development of severe immunopathology. Here the authors assess a range of immune parameters in both peripheral blood and respiratory samples, providing a
Externí odkaz:
https://doaj.org/article/3dbf74c705f948919beba2c6dc7dada4
Autor:
Lingyun Kong, Sofianos Andrikopoulos, Richard J MacIsaac, Laura K Mackay, David J Nikolic‐Paterson, Niloufar Torkamani, Neda Zafari, Evelyn C S Marin, Elif I Ekinci
Publikováno v:
Journal of Diabetes Investigation, Vol 13, Iss 2, Pp 213-226 (2022)
Abstract Diabetic kidney disease (DKD) is a highly prevalent complication of diabetes and the leading cause of end‐stage kidney disease. Inflammation is recognized as an important driver of progression of DKD. Activation of the immune response prom
Externí odkaz:
https://doaj.org/article/6acad139277844aaa238884180b0cf8c
Autor:
Varun J. Sharma, MBBS/BMedSci, MPH, Graham Starkey, MBBS, FRACS, Rohit D’Costa, MBBS, FRACS, FCICIM, Fiona James, BSc, Effie Mouhtouris, BSc, Lisa Davis, BSc, Boa Zhong Wang, MBBS, RACS, Angela Vago, RN, Jaishankar Raman, MBBS, MMed, PhD, FRACS, Laura K. Mackay, PhD, Helen Opdam, MBBS, FRACP, FCICM, Robert Jones, AM, MBChB, FRACS, M. Lindsay Grayson, AM, MBBS, MD, FRACP, Dominique E. Martin, MBBS, PhD, Claire L. Gordon, MBBS/BMedSci, MA, PhD, FRACP
Publikováno v:
Transplantation Direct, Vol 9, Iss 1, p e1422 (2023)
Background. We aimed to facilitate the donation of tissue samples for research by establishing a centralized system integrated in the organ donation program for collection, storage, and distribution of samples (the Australian Donation and Transplanta
Externí odkaz:
https://doaj.org/article/7c0ac6b083994e1eb8d0bce092bfe1bc
Autor:
Andrew Carr, Francis Thien, Jason Trubiano, Natasha E Holmes, Sara Vogrin, Winnie Tong, Heather Cleland, Johannes S Kern, Fiona James, James Yun, Jack Bourke, Ana-Maria Copaescu, Michelle S Y Goh, Effie Mouhtouris, Kyra Y L Chua, Andrew Awad, Joseph F De Luca, Celia Zubrinich, Douglas Gin, Abby Douglas, Constance H Katelaris, Sara Barnes, William B Smith, Tara Anderson, Amy Legg, Laura K Mackay, Ar Kar Aung, Elizabeth J Phillips
Publikováno v:
BMJ Open, Vol 12, Iss 8 (2022)
Introduction Severe cutaneous adverse reactions (SCAR) are a group of T cell-mediated hypersensitivities associated with significant morbidity, mortality and hospital costs. Clinical phenotypes include Stevens-Johnson syndrome (SJS), toxic epidermal
Externí odkaz:
https://doaj.org/article/1f63e34a5c004c4891050154a1bcfc5d
Autor:
Jessica Filtjens, Anais Roger, Linda Quatrini, Elisabeth Wieduwild, Jordi Gouilly, Guillaume Hoeffel, Rafaëlle Rossignol, Clara Daher, Guilhaume Debroas, Sandrine Henri, Claerwen M. Jones, Bernard Malissen, Laura K. Mackay, Aziz Moqrich, Francis R. Carbone, Sophie Ugolini
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Herpes simplex virus 1 (HSV-1) is a neurotropic virus that often cause pain via the induction of ulcer or blisters. Here the authors show, in mouse models of HSV-1 infection, that the pain-perceiving nociceptor Nav1.8 + neurons contribute to regulati
Externí odkaz:
https://doaj.org/article/42a3ec0604df491d8f51a1b9be9121c7
Autor:
Kylie M. Quinn, Tabinda Hussain, Felix Kraus, Luke E. Formosa, Wai K. Lam, Michael J. Dagley, Eleanor C. Saunders, Lisa M. Assmus, Erica Wynne-Jones, Liyen Loh, Carolien E. van de Sandt, Lucy Cooper, Kim L. Good-Jacobson, Katherine Kedzierska, Laura K. Mackay, Malcolm J. McConville, Georg Ramm, Michael T. Ryan, Nicole L. La Gruta
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Fatty acid oxidation (FAO) is thought to contribute to high spare respiratory capacity (SRC), which in turn affects CD8+ T cell function. Here, the authors show that ex vivo virtual memory T cells (and not antigen experienced memory T cells) have hig
Externí odkaz:
https://doaj.org/article/6da73ceced984a059e48b4f7619a183a