Zobrazeno 1 - 10
of 263
pro vyhledávání: '"Laura P. James"'
Autor:
Elizabeth J. Thompson, Angela Jeong, Victória E. Helfer, Valentina Shakhnovich, Andrea Edginton, Stephen J. Balevic, Laura P. James, David N. Collier, Ravinder Anand, Daniel Gonzalez, the Best Pharmaceuticals for Children Act – Pediatric Trials Network Steering Committee
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 13, Iss 8, Pp 1394-1408 (2024)
Abstract Pantoprazole is a proton pump inhibitor indicated for the treatment of gastroesophageal reflux disease, a condition that disproportionately affects children with obesity. Appropriately dosing pantoprazole in children with obesity requires un
Externí odkaz:
https://doaj.org/article/4ca30823adfe493396f3130d6019af5f
Autor:
Laura P. James, Robert Kimberly, Christopher John Lindsell, Jareen K. Meinzen-Derr, Ruth O’Hara
Publikováno v:
Journal of Clinical and Translational Science, Vol 8 (2024)
Externí odkaz:
https://doaj.org/article/6d39fb638c7b45d492f55ac634084df6
Autor:
Laura P. James, Crystal Sparks, Paul Duguid, Jessica Snowden, Mario Schootman, Brian Gittens, Beatrice Boateng, Antiño R. Allen
Publikováno v:
Journal of Clinical and Translational Science, Vol 8, Pp 33-33 (2024)
OBJECTIVES/GOALS: Minority faculty have inequitable access to information, professional development, and research resources. A structured research-mentoring program could help strengthen the research acumen of underrepresented (UR) faculty, provide a
Externí odkaz:
https://doaj.org/article/79cb30f168a648ffa1f7e1eba450a4b9
Autor:
Nicole K.H. Yiew, Joel H. Vazquez, Michael R. Martino, Stefanie Kennon-McGill, Jake R. Price, Felicia D. Allard, Eric U. Yee, Alexander J. Layman, Laura P. James, Kyle S. McCommis, Brian N. Finck, Mitchell R. McGill
Publikováno v:
Molecular Metabolism, Vol 77, Iss , Pp 101808- (2023)
Objective: Mitochondrial pyruvate is a critical intermediary metabolite in gluconeogenesis, lipogenesis, and NADH production. As a result, the mitochondrial pyruvate carrier (MPC) complex has emerged as a promising therapeutic target in metabolic dis
Externí odkaz:
https://doaj.org/article/d6d71cdcd46e41c5bc9d71d91d69be47
Autor:
Mitchell R. McGill, Laura P. James, Sandra S. McCullough, Jeffery H. Moran, Samuel E. Mathews, Eric C. Peterson, Davis P. Fleming, Morgan E. Tripod, Joel H. Vazquez, Stefanie Kennon‐McGill, Horace J. Spencer, Jonathan A. Dranoff
Publikováno v:
Hepatology Communications, Vol 6, Iss 2, Pp 361-373 (2022)
Current guidelines recommend restricting acetaminophen (APAP) use in patients with cirrhosis, but evidence to support that recommendation is lacking. Prior studies focused on pharmacokinetics (PK) of APAP in cirrhosis but did not rigorously examine c
Externí odkaz:
https://doaj.org/article/2ada1934f2dc4560b741f3c946e06c70
Autor:
Melissa M. Clemens, Stefanie Kennon-McGill, Joel H. Vazquez, Owen W. Stephens, Erich A. Peterson, Donald J. Johann, Felicia D. Allard, Eric U. Yee, Sandra S. McCullough, Laura P. James, Brian N. Finck, Mitchell R. McGill
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3836-3846 (2021)
We previously demonstrated that endogenous phosphatidic acid (PA) promotes liver regeneration after acetaminophen (APAP) hepatotoxicity. Here, we hypothesized that exogenous PA is also beneficial. To test that, we treated mice with a toxic APAP dose
Externí odkaz:
https://doaj.org/article/4a3814ab452048b8af9da9c8afc86904
Autor:
Melissa M. Clemens, Joel H. Vazquez, Stefanie Kennon-McGill, Sandra S. McCullough, Laura P. James, Mitchell R. McGill
Publikováno v:
Liver Research, Vol 4, Iss 3, Pp 145-152 (2020)
Background and aim: Acetaminophen (APAP) overdose is a major cause of acute liver injury, but the role of macrophages in the propagation of the hepatotoxicity is controversial. Early research revealed that macrophage inhibitors protect against APAP i
Externí odkaz:
https://doaj.org/article/58c6f21bf8b54812ba9fde44dcecdb1a
Autor:
Pearl A. McElfish, Christopher R. Long, Laura P. James, Aaron J. Scott, Elizabeth Flood-Grady, Kim S. Kimminau, Robert L. Rhyne, Mark R. Burge, Rachel S. Purvis
Publikováno v:
Journal of Clinical and Translational Science, Vol 3, Pp 295-301 (2019)
AbstractIntroduction:Research participants want to receive results from studies in which they participate. However, health researchers rarely share the results of their studies beyond scientific publication. Little is known about the barriers researc
Externí odkaz:
https://doaj.org/article/66f83f7883f646868b5fbca65a9a663e
Autor:
Christopher R. Long, Rachel S. Purvis, Elizabeth Flood-Grady, Kim S. Kimminau, Robert L. Rhyne, Mark R. Burge, M. Kathryn Stewart, Amy J. Jenkins, Laura P. James, Pearl A. McElfish
Publikováno v:
Health Research Policy and Systems, Vol 17, Iss 1, Pp 1-11 (2019)
Abstract Background Although research participants are generally interested in receiving results from studies in which they participate, health researchers rarely communicate study findings to participants. The present study was designed to provide o
Externí odkaz:
https://doaj.org/article/27f7fe0c529a446c854fde3eea0e224f
Autor:
Pearl A. McElfish, Don E. Willis, Keneshia Bryant-Moore, Martha O. Rojo, Jennifer A. Andersen, Kyle F. Kaminicki, Laura P. James
Publikováno v:
Journal of Primary Care & Community Health, Vol 12 (2021)
Introduction: A contributing factor to racial and ethnic disparities during the COVID-19 pandemic may be the accessibility and acceptability of COVID-19 testing. Previous studies found that access to testing has not been equitable across several soci
Externí odkaz:
https://doaj.org/article/27784af3e3b844d682acd8c4a84637f7