Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Laura P O'Neill"'
Autor:
Stephanie Dumon, David S Walton, Giacomo Volpe, Nicola Wilson, Emilie Dassé, Walter Del Pozzo, Josette-Renee Landry, Bryan Turner, Laura P O'Neill, Berthold Göttgens, Jon Frampton
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e43300 (2012)
Product of the Itga2b gene, CD41 contributes to hematopoietic stem cell (HSC) and megakaryocyte/platelet functions. CD41 expression marks the onset of definitive hematopoiesis in the embryo where it participates in regulating the numbers of multipote
Externí odkaz:
https://doaj.org/article/07efdd6b1a7f4fbd9e0c1812cd05afc0
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33453 (2012)
Histone deacetylase inhibitors (HDACi) are increasingly used as therapeutic agents, but the mechanisms by which they alter cell behaviour remain unclear. Here we use microarray expression analysis to show that only a small proportion of genes (∼9%)
Externí odkaz:
https://doaj.org/article/807e277a158b4988a06929a0a365d703
Publikováno v:
PLoS ONE, Vol 4, Iss 6, p e6086 (2009)
Enzyme-catalyzed, post-translational modifications of core histones have been implicated in the complex changes in gene expression that drive early mammalian development. However, until recently the small number of cells available from the preimplant
Externí odkaz:
https://doaj.org/article/922eb8cc850644baa892133c0cc230e2
Autor:
Hong Lin, Vibhor Gupta, Matthew D Vermilyea, Francesco Falciani, Jeannie T Lee, Laura P O'Neill, Bryan M Turner
Publikováno v:
PLoS Biology, Vol 5, Iss 12, p e326 (2007)
Dosage compensation in mammals involves silencing of one X chromosome in XX females and requires expression, in cis, of Xist RNA. The X to be inactivated is randomly chosen in cells of the inner cell mass (ICM) at the blastocyst stage of development.
Externí odkaz:
https://doaj.org/article/6fe7ef6ab2cd4451b3e80539b38e81cc
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2076
The islets of Langerhans are clusters of cells dispersed throughout the pancreas that produce several hormones essential for controlling a variety of metabolic processes, including glucose homeostasis and lipid metabolism. Studying the transcriptiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::88b0ecefd3301bdc5da16106e6604aac
https://pubmed.ncbi.nlm.nih.gov/31586329
https://pubmed.ncbi.nlm.nih.gov/31586329
Publikováno v:
Methods in Molecular Biology ISBN: 9781493998807
The islets of Langerhans are clusters of cells dispersed throughout the pancreas that produce several hormones essential for controlling a variety of metabolic processes, including glucose homeostasis and lipid metabolism. Studying the transcriptiona
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4183d2fc08ac61e29491050d1521e5da
https://doi.org/10.1007/978-1-4939-9882-1_11
https://doi.org/10.1007/978-1-4939-9882-1_11
Autor:
Laura P. O'Neill, M Griffiths, Emilie Dassé, W. Del Pozzo, Paloma Garcia, Stephanie Dumon, David S. Walton, Giacomo Volpe, Jon Frampton
Publikováno v:
Leukemia. 27:1487-1496
The interaction between the receptor FLT3 (FMS-like tyrosine kinase-3) and its ligand FL leads to crucial signalling during the early stages of the commitment of haematopoietic stem cells. Mutation or over-expression of the FLT3 gene, leading to cons
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8864a4201aa488698a0624836ff87dd
https://doi.org/10.1038/leu.2013.23
https://doi.org/10.1038/leu.2013.23
Autor:
Craig L. Doig, Michelle Sobolewski, Sebastiano Battaglia, Christopher McCabe, Vineet K. Dhiman, Bryan M. Turner, Laura P. O'Neill, Moray J. Campbell, Dominic J. Smiraglia, James L. Thorne, Orla Maguire, Prashant Singh
Publikováno v:
Carcinogenesis. 34:248-256
The current study investigated transcriptional distortion in prostate cancer cells using the vitamin D receptor (VDR) as a tool to examine how epigenetic events driven by corepressor binding and CpG methylation lead to aberrant gene expression. These
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff38b3e791ff19afbc67b3b0bc3c6376
https://doi.org/10.1093/carcin/bgs331
https://doi.org/10.1093/carcin/bgs331
Autor:
Santiago Uribe-Lewis, Charlotte Ling, Miguel Constância, R. Huw Jones, Victor E. Marquez, Mohammed Tadayyon, William Cairns, Laura P. O'Neill, Yoko Ito, Adele Murrell, Marloes Dekker Nitert, Ionel Sandovici, Susan E. Ozanne, Noel H. Smith, Matthew Ackers-Johnson
Publikováno v:
Proceedings of the National Academy of Sciences. 108:5449-5454
Environmental factors interact with the genome throughout life to determine gene expression and, consequently, tissue function and disease risk. One such factor that is known to play an important role in determining long-term metabolic health is diet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::434f40ac9b678df8f02a3ff21b21204c
https://doi.org/10.1073/pnas.1019007108
https://doi.org/10.1073/pnas.1019007108
Autor:
Laura P. O'Neill, Christopher McCabe, Carsten Carlberg, Merja Heinäniemi, Bryan Turner, Leah Fehr, Craig L. Doig, Sebastiano Battaglia, Lara Sucheston, Moray J. Campbell, Orla Maguire, James L. Thorne
Publikováno v:
Nucleic Acids Research
In non-malignant RWPE-1 prostate epithelial cells signaling by the nuclear receptor Vitamin D Receptor (VDR, NR1I1) induces cell cycle arrest through targets including CDKN1A (encodes p21((waf1/cip1))). VDR dynamically induced individual histone modi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd51dc02f2755ac29945fb609b6a95c1
https://doi.org/10.1093/nar/gkq875
https://doi.org/10.1093/nar/gkq875