Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Laura P, Van Lieshout"'
Autor:
Laura P. van Lieshout, Miranda Rubin, Katrina Costa-Grant, Stacy Ota, Diane Golebiowski, Troy Panico, Eli Wiberg, Klaudia Szymczak, Richard Gilmore, Marissa Stanvick, Brenda Burnham, Jeff Gagnon, Ifeyinwa Iwuchukwu, Guang Yang, Iraj Ghazi, Alex Meola, Ryan Dickerson, Thomas Thiers, Luke Mustich, April Hayes, Israel Rivas, Jason Lotterhand, Nancy Avila, James McGivney, Jin Yin, Tim Kelly
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 426-436 (2023)
Transient transfection of mammalian cells using plasmid DNA is a standard method to produce adeno-associated virus (AAV) vectors allowing for flexible and scalable manufacture. Typically, three plasmids are used to encode the necessary components to
Externí odkaz:
https://doaj.org/article/25fd1b8281394ec9b15853de27025cb5
Autor:
Laura P. van Lieshout, Amira D. Rghei, Wenguang Cao, Shihua He, Geoff Soule, Wenjun Zhu, Sylvia P. Thomas, Debra Sorensen, Kathy Frost, Kevin Tierney, Brad Thompson, Stephanie Booth, David Safronetz, Raveendra R. Kulkarni, Byram W. Bridle, Xiangguo Qiu, Logan Banadyga, Sarah K. Wootton
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 26, Iss , Pp 505-518 (2022)
Filoviruses cause severe hemorrhagic fever with case fatality rates as high as 90%. Filovirus-specific monoclonal antibodies (mAbs) confer protection in nonhuman primates as late as 5 days after challenge, and FDA-approved mAbs REGN-EB3 and mAb114 ha
Externí odkaz:
https://doaj.org/article/50cc389f7095494bba9d58a113335768
Autor:
Darrick L. Yu, Laura P. van Lieshout, Brenna A. Y. Stevens, Kelsie J. (Jagt) Near, Jenny K. Stodola, Kevin J. Stinson, Durda Slavic, Sarah K. Wootton
Publikováno v:
Viruses, Vol 16, Iss 1, p 57 (2023)
Adeno-associated virus (AAV) vectors are among the most widely used delivery vehicles for in vivo gene therapy as they mediate robust and sustained transgene expression with limited toxicity. However, a significant impediment to the broad clinical su
Externí odkaz:
https://doaj.org/article/03d782a89b9b4b69b161f7c5f155a7d8
Autor:
Martin H. Kang, Laura P. van Lieshout, Liqun Xu, Jakob M. Domm, Arul Vadivel, Laurent Renesme, Christian Mühlfeld, Maria Hurskainen, Ivana Mižíková, Yanlong Pei, Jacob P. van Vloten, Sylvia P. Thomas, Claudia Milazzo, Chanèle Cyr-Depauw, Jeffrey A. Whitsett, Lawrence M. Nogee, Sarah K. Wootton, Bernard Thébaud
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Surfactant protein B (SP-B) deficiency is a genetic lung disease that results in lethal respiratory distress within months of birth. Here, the authors describe a gene therapy strategy using a rationally designed AAV6 capsid that restores surfactant h
Externí odkaz:
https://doaj.org/article/6438f94f53b5451b8361dfa466593f2a
Autor:
Laura P. van Lieshout, Jakob M. Domm, Tara N. Rindler, Kathy L. Frost, Debra L. Sorensen, Sarah J. Medina, Stephanie A. Booth, James P. Bridges, Sarah K. Wootton
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 9, Iss , Pp 323-329 (2018)
Gene therapy for the treatment of genetic disorders has demonstrated considerable therapeutic success in clinical trials. Among the most effective and commonly used gene delivery vectors are those based on adeno-associated virus (AAV). Despite these
Externí odkaz:
https://doaj.org/article/2911c1cd90a04b1b9fa657f70797c3f5
Autor:
Amira D. Rghei, Laura P. van Lieshout, Benjamin M. McLeod, Yanlong Pei, Jordyn A. Lopes, Nicole Zielinska, Enzo M. Baracuhy, Brenna A. Y. Stevens, Sylvia P. Thomas, Jacob G. E. Yates, Bryce M. Warner, Darwyn Kobasa, Hugues Fausther-Bovendo, Gary P. Kobinger, Khalil Karimi, Brad Thompson, Byram W. Bridle, Leonardo Susta, Sarah K. Wootton
Publikováno v:
Biomedicines, Vol 9, Iss 9, p 1186 (2021)
Adeno-associated virus (AAV) vector mediated expression of therapeutic monoclonal antibodies is an alternative strategy to traditional vaccination to generate immunity in immunosuppressed or immunosenescent individuals. In this study, we vectorized a
Externí odkaz:
https://doaj.org/article/f323e697c3344c79998e1eb3bd389d59
Autor:
Lisa A. Santry, Joelle C. Ingrao, Darrick L. Yu, Jondavid G. de Jong, Laura P. van Lieshout, Geoffrey A. Wood, Sarah K. Wootton
Publikováno v:
BMC Biotechnology, Vol 17, Iss 1, Pp 1-11 (2017)
Abstract Background Targeted delivery of gene therapy vectors to the mouse respiratory tract is often performed via intranasal or intratracheal administration; however, there can be a great deal of variability between these methods, which could poten
Externí odkaz:
https://doaj.org/article/0a86162c18e2447aadfb2770bef09e55
Autor:
Amira D. Rghei, Jacob G. E. Yates, Jordyn A. Lopes, Xuiaoyan Zhan, Matthew M. Guilleman, Yanlong Pei, Laura P. van Lieshout, Lisa A. Santry, Byram W. Bridle, Khalil Karimi, Brad Thompson, Leonardo Susta, James E. Crowe, Sarah K. Wootton
Publikováno v:
Gene Therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::99abd0c9768f47d56184c8277e05709a
https://doi.org/10.1038/s41434-023-00385-2
https://doi.org/10.1038/s41434-023-00385-2
Autor:
Amira D. Rghei, Laura P. van Lieshout, Lisa A. Santry, Matthew M. Guilleman, Sylvia P. Thomas, Leonardo Susta, Khalil Karimi, Byram W. Bridle, Sarah K. Wootton
Publikováno v:
Tropical Medicine and Infectious Disease, Vol 5, Iss 4, p 169 (2020)
Filoviruses are among the deadliest infectious agents known to man, causing severe hemorrhagic fever, with up to 90% fatality rates. The 2014 Ebola outbreak in West Africa resulted in over 28,000 infections, demonstrating the large-scale human health
Externí odkaz:
https://doaj.org/article/46be403b99ab488583d634e852cda2bd
Autor:
Amira D. Rghei, Laura P. van Lieshout, Wenguang Cao, Shihua He, Kevin Tierney, Jordyn A. Lopes, Nicole Zielinska, Enzo M. Baracuhy, Elena S. B. Campbell, Jessica A. Minott, Matthew M. Guilleman, Pamela C. Hasson, Brad Thompson, Khalil Karimi, Byram W. Bridle, Leonardo Susta, Xiangguo Qiu, Logan Banadyga, Sarah K. Wootton
Publikováno v:
Gene Therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::584dabd64ff3c78e72b555e5a326eb5d
https://doi.org/10.1038/s41434-022-00361-2
https://doi.org/10.1038/s41434-022-00361-2