Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Laura Ortet"'
Autor:
Etna Abad, Jérémy Sandoz, Gerard Romero, Ivan Zadra, Julia Urgel-Solas, Pablo Borredat, Savvas Kourtis, Laura Ortet, Carlos M. Martínez, Donate Weghorn, Sara Sdelci, Ana Janic
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-25 (2024)
Abstract Background TP53, the most frequently mutated gene in human cancers, orchestrates a complex transcriptional program crucial for cancer prevention. While certain TP53-dependent genes have been extensively studied, others, like the recently ide
Externí odkaz:
https://doaj.org/article/05057dea24dc4caab17c91272a5fc686
Autor:
Jessica Segalés, Eusebio Perdiguero, Antonio L. Serrano, Pedro Sousa-Victor, Laura Ortet, Mercè Jardí, Andrei V. Budanov, Laura Garcia-Prat, Marco Sandri, David M. Thomson, Michael Karin, Jun Hee Lee, Pura Muñoz-Cánoves
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Ageing is associated with muscle atrophy, which negatively impacts quality of life. Here the authors show that expression of sestrins decreases during inactivity and that their overexpression prevents atrophy in mice via modulation of autophagy and p
Externí odkaz:
https://doaj.org/article/36ab756e6fc848bfb843ed2f784d654b
Autor:
Ana, Guerrero, Andrew J, Innes, Pierre-François, Roux, Sonja C, Buisman, Johannes, Jung, Laura, Ortet, Victoria, Moiseeva, Verena, Wagner, Lucas, Robinson, Albertina, Ausema, Anna, Potapova, Eusebio, Perdiguero, Ellen, Weersing, Marieke, Aarts, Nadine, Martin, Torsten, Wuestefeld, Pura, Muñoz-Cánoves, Gerald, de Haan, Oliver, Bischof, Jesús, Gil
Publikováno v:
Nat Aging
Cellular senescence is a stable type of cell cycle arrest triggered by different stresses. As such, senescence drives age-related diseases and curbs cellular replicative potential. Here, we show that 3-deazaadenosine (3DA), an S-adenosyl homocysteina
Autor:
Victoria Moiseeva, Andrés Cisneros, Valentina Sica, Oleg Deryagin, Yiwei Lai, Sascha Jung, Eva Andrés, Juan An, Jessica Segalés, Laura Ortet, Vera Lukesova, Giacomo Volpe, Alberto Benguria, Ana Dopazo, Salvador Aznar Benitah, Yasuteru Urano, Antonio del Sol, Miguel A. Esteban, Yasuyuki Ohkawa, Antonio L. Serrano, Eusebio Perdiguero, Pura Muñoz-Cánoves
Publikováno v:
Nature. 614:E45-E45
Autor:
Stephen R. Brooks, Hong-Wei Sun, Vittorio Sartorelli, Kan Jiang, Marco Sandri, Laura Ortet, Stefania Dell'Orso, Srikanth Ravichandran, Sonia Alonso-Martin, Aster H. Juan, Laura García-Prat, Victoria Moiseeva, Marta Flández, Eusebio Perdiguero, Vanessa Ruiz-Bonilla, Pura Muñoz-Cánoves, Elena Rebollo, Mercè Jardí, Antonio Musarò, Xiaotong Hong, Antonio del Sol, Silvia Campanario
Publikováno v:
Nature Cell Biology
Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC. Repositorio Institucional del CSIC
instname
Tissue regeneration declines with ageing but little is known about whether this arises from changes in stem-cell heterogeneity. Here, in homeostatic skeletal muscle, we identify two quiescent stem-cell states distinguished by relative CD34 expression
Autor:
Ana Guerrero, Andrew J. Innes, Pierre-François Roux, Sonja C. Buisman, Johannes Jung, Laura Ortet, Victoria Moiseeva, Verena Wagner, Lucas Robinson, Albertina Ausema, Anna Potapova, Eusebio Perdiguero, Ellen Weersing, Marieke Aarts, Nadine Martin, Torsten Wuestefeld, Pura Muñoz-Cánoves, Gerald de Haan, Oliver Bischof, Jesús Gil
Publikováno v:
Nature Aging, 2(9), 851-866. Springer Nature
Nature Aging
Nature Aging, 2022, 2 (9), pp.851-866. ⟨10.1038/s43587-022-00279-9⟩
Nature Aging, 2(9), 851-866. Springer
Nature Aging
Nature Aging, 2022, 2 (9), pp.851-866. ⟨10.1038/s43587-022-00279-9⟩
Nature Aging, 2(9), 851-866. Springer
Cellular senescence is a stable type of cell cycle arrest triggered by different stresses. As such, senescence drives age-related diseases and curbs cellular replicative potential. Here, we show that 3-deazaadenosine (3DA), an S-adenosyl homocysteina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9a6470d847b2c11cc52193177a2a39c
http://hdl.handle.net/10230/56607
http://hdl.handle.net/10230/56607
Autor:
Victoria Moiseeva, Andrés Cisneros, Valentina Sica, Oleg Deryagin, Yiwei Lai, Sascha Jung, Eva Andrés, Juan An, Jessica Segalés, Laura Ortet, Vera Lukesova, Giacomo Volpe, Alberto Benguria, Ana Dopazo, Salvador Aznar Benitah, Yasuteru Urano, Antonio del Sol, Miguel A. Esteban, Yasuyuki Ohkawa, Antonio L. Serrano, Eusebio Perdiguero, Pura Muñoz-Cánoves
Publikováno v:
Nature
Tissue regeneration requires coordination between resident stem cells and local niche cells1,2. Here we identify that senescent cells are integral components of the skeletal muscle regenerative niche that repress regeneration at all stages of life. T
Autor:
Pedro Sousa-Victor, Laura García-Prat, Pura Muñoz-Cánoves, David M. Thomson, Marco Sandri, Antonio L. Serrano, Andrei V. Budanov, Jun Hee Lee, Jessica Segalés, Michael Karin, Laura Ortet, Eusebio Perdiguero, Mercè Jardí
Publikováno v:
Nature Communications
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repisalud
Instituto de Salud Carlos III (ISCIII)
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
Repisalud
Instituto de Salud Carlos III (ISCIII)
© The Author(s) 2020. Open Access: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriat
Autor:
Laura García-Prat, Pedro Sousa-Victor, Javier Rodríguez-Ubreva, Antonio L. Serrano, Esteban Ballestar, Eusebio Perdiguero, Mercè Jardí, Pura Muñoz-Cánoves, Susana Gutarra, Vanessa Ruiz-Bonilla, Laura Ortet, Susana González
Publikováno v:
Nature. 506:316-321
Regeneration of skeletal muscle depends on a population of adult stem cells (satellite cells) that remain quiescent throughout life. Satellite cell regenerative functions decline with ageing. Here we report that geriatric satellite cells are incapabl
Autor:
Ruiz-Bonilla, Susana Gutarra, Marta Martinez-Vicente, Javier Rodríguez-Ubreva, Pura Muñoz-Cánoves, Laura García-Prat, Esteban Ballestar, Eusebio Perdiguero, Antonio L. Serrano, Marco Sandri, Laura Ortet, Elena Rebollo
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
Laura García-Prat et al.
During ageing, muscle stem-cell regenerative function declines. At advanced geriatric age, this decline is maximal owing to transition from a normal quiescence into an irreversible senescence state. How satellite cells
During ageing, muscle stem-cell regenerative function declines. At advanced geriatric age, this decline is maximal owing to transition from a normal quiescence into an irreversible senescence state. How satellite cells