Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Laura Ortega Torres"'
Autor:
Diego Marescotti, Carole Mathis, Vincenzo Belcastro, Patrice Leroy, Stefano Acali, Florian Martin, Rémi Dulize, David Bornand, Dariusz Peric, Emmanuel Guedj, Laura Ortega Torres, Matteo Biasioli, Matthieu Fuhrimann, Estela Fernandes, Felix Frauendorfer, Ignacio Gonzalez Suarez, Davide Sciuscio, Nikolai V. Ivanov, Manuel C. Peitsch, Julia Hoeng
Publikováno v:
Toxicology Reports, Vol 7, Iss , Pp 67-80 (2020)
The development of reduced-risk products aims to provide alternatives to cigarettes that present less risk of harm for adult smokers. Responsible use of flavoring substances in these products may fulfill an important role in product acceptance. While
Externí odkaz:
https://doaj.org/article/68c51b0570854c5e873f9c4ebe2b2a39
Autor:
Ignacio Gonzalez Suarez, Remi Dulize, Dariusz Peric, Patrice Leroy, Felix Frauendorfer, Matteo Biasioli, Stefano Acali, Manuel C. Peitsch, Julia Hoeng, Diego Marescotti, Emmanuel Guedj, Davide Sciuscio, Nikolai V. Ivanov, Florian Martin, Estela Fernandes, Matthieu Fuhrimann, Vincenzo Belcastro, David Bornand, Carole Mathis, Laura Ortega Torres
Publikováno v:
Toxicology Reports, Vol 7, Iss, Pp 67-80 (2020)
Toxicology Reports
Toxicology Reports
Graphical abstract
Highlights • A 3-step approach combining 1) real-time cytotoxicity, 2) high-content screening and 3) gene expression analysis was developed in NHBE cells. • Different scoring methods were developed enabling a ranking based
Highlights • A 3-step approach combining 1) real-time cytotoxicity, 2) high-content screening and 3) gene expression analysis was developed in NHBE cells. • Different scoring methods were developed enabling a ranking based
Autor:
Filippo Zanetti, Keyur Trivedi, Yang Xiang, Utkarsh Doshi, Sandro Steiner, Laura Ortega Torres, Kyeonghee Monica Lee, Manuel C. Peitsch, Willie J. McKinney, Nikolai V. Ivanov, Florian Martin, Stefan Frentzel, Anita R. Iskandar, Patrice Leroy, Shoaib Majeed, Julia Hoeng, Celine Merg, Emmanuel Guedj, Athanasios Kondylis
Publikováno v:
Internal and Emergency Medicine
In the context of tobacco harm-reduction strategy, the potential reduced impact of electronic cigarette (EC) exposure should be evaluated relative to the impact of cigarette smoke exposure. We conducted a series of in vitro studies to compare the bio
Autor:
Stefan Frentzel, Tomasso Serchi, Arno C. Gutleb, Keyur Trivedi, Patrice Leroy, Julia Hoeng, Elisa Moschini, Albert Giralt, Celine Merg, Nikolai V. Ivanov, Florian Martin, Laura Ortega-Torres, Anita R. Iskandar, Diego Marescotti, Shoaib Majeed, Emmanuel Guedj, Athanasios Kondylis, Manuel C. Peitsch
Publikováno v:
Toxicology letters. 337
Exposure to aerosol from electronic vapor (e-vapor) products has been suggested to result in less risk of harm to smokers than cigarette smoke (CS) exposure. Although many studies on e-vapor products have tested the effects of liquid formulations on
Autor:
Maria Fatarova, Laura Ortega Torres, Keyur Trivedi, Philippe A. Guy, Albert Giralt, Julia Hoeng, Laurent Neau, Maica Corciulo, Stefan Frentzel, Florian Calvino, Manuel C. Peitsch, Celine Merg, Emmanuel Guedj, Athanasios Kondylis, Aditya Reddy Kolli, Nikolai V. Ivanov, Shoaib Majeed, Anita R. Iskandar
Publikováno v:
Food and Chemical Toxicology. 157:112577
Trehalose is added in drug formulations to act as fillers or improve aerosolization performance. Its characteristics as a carrier molecule have been explored; however, the fate of trehalose in human airway tissues has not been thoroughly investigated
Autor:
Emmanuel Guedj, Celine Merg, Alain Sewer, Stefan Frentzel, Walter K. Schlage, Yannick Martinez, Patrice Leroy, Julia Hoeng, Manuel C. Peitsch, Shoaib Majeed, Nikolai V. Ivanov, Anita R. Iskandar, Florian Martin, Carole Mathis, Laura Ortega Torres, Keyur Trivedi
Publikováno v:
Toxicol. Res.. 6:930-946
Using an in vitro human small airway epithelium model, we assessed the biological impact of an aerosol from a candidate modified-risk tobacco product, the tobacco heating system (THS) 2.2, to investigate the potential reduced risk of THS2.2 aerosol e
Autor:
Patrice Leroy, Shoaib Majeed, Alain Sewer, Stefano Acali, Anita R. Iskandar, Diego Marescotti, Emmanuel Guedj, Athanasios Kondylis, Julia Hoeng, Bjorn Titz, Filippo Zanetti, Vincenzo Belcastro, Keyur Trivedi, Manuel C. Peitsch, Stefan Frentzel, Celine Merg, Laura Ortega Torres, Thomas Schneider, Sandro Steiner, Nikolai V. Ivanov, Florian Martin
Publikováno v:
Archives of toxicology. 93(11)
We previously proposed a systems toxicology framework for in vitro assessment of e-liquids. The framework starts with the first layer aimed at screening the potential toxicity of e-liquids, followed by the second layer aimed at investigating the toxi
Autor:
Brian R. Keppler, Stefan Frentzel, Ashraf Elamin, Giuseppe Lo Sasso, Walter K. Schlage, Manuel C. Peitsch, Shoaib Majeed, Emmanuel Guedj, Filippo Zanetti, Nikolai V. Ivanov, Florian Martin, Laura Ortega Torres, Alain Sewer, Julia Hoeng, Patrice Leroy, Bjoern Titz, Keyur Trivedi, Carole Mathis, Elena Scotti
Publikováno v:
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 101
Smoking is one of the major lifestyle-related risk factors for periodontal diseases. Modified risk tobacco products (MRTP) offer a promising alternative in the harm reduction strategy for adult smokers unable to quit. Using a systems toxicology appro
Autor:
Keyur Trivedi, Filippo Zanetti, Manuel C. Peitsch, Stefan Frentzel, Patrice Leroy, Laura Ortega Torres, Nikolai V. Ivanov, Ashraf Elamin, Alain Sewer, Shoaib Majeed, Emmanuel Guedj, Julia Hoeng
Publikováno v:
Toxicology Letters. 280:S262
Autor:
Israel Fernandez-Cadenas, Anna Penalba, Pilar Delgado, Manolo Quintana, Anna Rosell, Joan Montaner, José Alvarez-Sabín, Laura Ortega-Torres, Marc Ribó, Carlos A. Molina
Publikováno v:
Neuroscience letters. 398(3)
Angiotensin converting enzyme (ACE) influences vessels tone and the coagulation/fibrinolysis system. The ACE gene I/D polymorphism has been linked with PAI-1 and fibrinogen levels and with Factors VII and X activities. Therefore, we aimed to test whe