Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Laura Novaroli"'
Autor:
Laura Novaroli, Antoine Daina, Francesca Bertolini, Saviana Di Giovanni, Juan Bravo, Marianne Reist, Pierre-Alain Carrupt
Publikováno v:
CHIMIA, Vol 59, Iss 6 (2005)
Aging related neurodegenerative disorders such as Parkinson disease (PD) and Alzheimer's disease (AD) are the result of multiple pathophysiological pathways that contribute to the neurodegenerative cascade. Hence, multifunctional drug candidates able
Externí odkaz:
https://doaj.org/article/e36e8b1308f14fbfb4ba56889c9275dc
Publikováno v:
CHIMIA, Vol 59, Iss 6 (2005)
Successful drug research depends on adequate links between therapeutic benefits for the treatment of a disease, pertinent biological targets and suitable chemical compounds. The pharmacochemistry group at EPGL is active in the development of virtual
Externí odkaz:
https://doaj.org/article/54eb1845013e438ea11659fff8b8aa3f
Autor:
Valerie Nicolas-Metral, Laura Novaroli, Jean-Maurice Dumont, Raf Crabbé, Judith Marfurt, Grégoire Vuagniaux
Publikováno v:
Expert opinion on investigational drugs. 18(2)
Debio 025 is a cyclophilin (Cyp) inhibitor without calcineurin-binding properties. The drug inhibits viral replication of genotype 1b and 2a replicons in nanomolar concentrations and shows an additive to synergistic antiviral effect with interferon,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5925bd1da817c7c86cb752193a2e0d4f
https://pubmed.ncbi.nlm.nih.gov/19236267
https://pubmed.ncbi.nlm.nih.gov/19236267
Publikováno v:
Journal of Pharmaceutical Sciences, Vol. 96, No 11 (2007) pp. 2931-44
Oxidative damage to proteins, implicated amongst other in the etiology and progression of Parkinson's disease (PD) and Alzheimer's disease (AD), results in the loss of specific biological protein function. A simple, sensitive, and cost-effective fluo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::359b0123c8cd6a1eaa5399d8eb7b41db
https://archive-ouverte.unige.ch/unige:889
https://archive-ouverte.unige.ch/unige:889
Autor:
Marco Catto, Marianne Reist, Angelo Carotti, Antoine Daina, Elisabeth Favre, Laura Novaroli, Francesco Leonetti, Juan Bravo, Pierre-Alain Carrupt
Publikováno v:
Journal of Medicinal Chemistry, Vol. 49, No 21 (2006) pp. 6264-6272
The impact of species-dependent differences between human and rat MAO B on inhibitor screening was evidenced for two classes of compounds, coumarin and 5H-indeno[1,2-c]pyridazin-5-one derivatives. All examined compounds have shown a greater inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2baac238e136a0d53c1d18e33741243d
https://pubmed.ncbi.nlm.nih.gov/17034132
https://pubmed.ncbi.nlm.nih.gov/17034132
Autor:
Geraldine Bouchard Doulakas, Alberto Gasco, Roberta Fruttero, Pierre-Alain Carrupt, Barbara Rolando, Laura Novaroli, Marianne Reist
Publikováno v:
Helvetica Chimica Acta, Vol. 89, No 1 (2006) pp. 144-152
The ionization and lipophilicity properties of the second-generation catechol-O-methyltransferase (COMT) inhibitors entacapone (1), nitecapone (2), and tolcapone (3) which share the same nitrocatechol structure but have remarkably different pharmacok
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131bde293e98f3be13a6da2e90202977
https://archive-ouverte.unige.ch/unige:10618
https://archive-ouverte.unige.ch/unige:10618
Autor:
Pierre-Alain Carrupt, Angelo Carotti, Marco Catto, Elisabeth Favre, Laura Novaroli, Marianne Reist
Publikováno v:
Bioorganic & Medicinal Chemistry, Vol. 13, No 22 (2005) pp. 6212-6217
Interest in inhibitors of monoamine oxidase type B (MAO B) has grown in recent years, due to their therapeutic potential in aging-related neurodegenerative diseases, such as Parkinson's disease and Alzheimer's disease. This study is devoted to the us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4126dbda683c7dd017a7d37be978e7b9
https://pubmed.ncbi.nlm.nih.gov/16054369
https://pubmed.ncbi.nlm.nih.gov/16054369
Publikováno v:
Chimia, Vol. 59, No 6 (2005) pp. 295-298
CHIMIA, Vol 59, Iss 6 (2005)
CHIMIA, Vol 59, Iss 6 (2005)
Successful drug research depends on adequate links between therapeutic benefits for the treatment of a disease, pertinent biological targets and suitable chemical compounds. The pharmacochemistry group at EPGL is active in the development of virtual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41494e8f5dc835610abfd3532330c590
https://archive-ouverte.unige.ch/unige:9964
https://archive-ouverte.unige.ch/unige:9964
Autor:
Alex Avdeef, Giuseppe Ermondi, Jeffrey A. Ruell, Oksana Tsinman, Laura Novaroli, Alessandro Damiano, Giulia Caron
Publikováno v:
Bioorganicmedicinal chemistry. 12(23)
This paper uses a recent approach toward drug discovery, in which in silico tools and experimental data are combined together to study the structural features of amlodipine and their relevance in the peculiar pharmacodynamic and pharmacokinetic profi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34a427308080b0ec8ed04c5b44cb434
https://pubmed.ncbi.nlm.nih.gov/15519156
https://pubmed.ncbi.nlm.nih.gov/15519156
Autor:
Francesca Bertolini, Laura Novaroli, Antoine Daina, Saviana Di Giovanni, Pierre-Alain Carrupt, Marianne Reist, Juan Bravo
Publikováno v:
Chimia, Vol. 59, No 6 (2005) pp. 315-320
CHIMIA, Vol 59, Iss 6 (2005)
CHIMIA, Vol 59, Iss 6 (2005)
Aging related neurodegenerative disorders such as Parkinson disease (PD) and Alzheimer's disease (AD) are the result of multiple pathophysiological pathways that contribute to the neurodegenerative cascade. Hence, multifunctional drug candidates able
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1658cb9fdfc9d321a2d01cc60f016eb
https://doi.org/10.2533/000942905777676407
https://doi.org/10.2533/000942905777676407