Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Laura Neises"'
Autor:
Laura Neises, Catherine Delbrouck, Anne Schuster, Mahsa Rezaipour, Kim Eiden, Anais Oudin, Carina Fabian, Simone P. Niclou, Anna Golebiewska, Johannes Meiser
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103401- (2024)
Summary: Herein, we present an ex vivo approach to study glioblastoma (GBM) cell motility in viable mouse brain slice cultures, closely mimicking in vivo features. We detail the preparation and culturing of mouse brain slices followed by tumor cell i
Externí odkaz:
https://doaj.org/article/45be177943ce484f8d03edc7d94b6004
Autor:
Björn Becker, Felix Wottawa, Mohamed Bakr, Eric Koncina, Lisa Mayr, Julia Kugler, Guang Yang, Samuel J. Windross, Laura Neises, Neha Mishra, Danielle Harris, Florian Tran, Lina Welz, Julian Schwärzler, Zoltán Bánki, Stephanie T. Stengel, Go Ito, Christina Krötz, Olivia I. Coleman, Christian Jaeger, Dirk Haller, Søren R. Paludan, Richard Blumberg, Arthur Kaser, Luka Cicin-Sain, Stefan Schreiber, Timon E. Adolph, Elisabeth Letellier, Philip Rosenstiel, Johannes Meiser, Konrad Aden
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109173- (2024)
Summary: Inflammatory bowel diseases are characterized by the chronic relapsing inflammation of the gastrointestinal tract. While the molecular causality between endoplasmic reticulum (ER) stress and intestinal inflammation is widely accepted, the me
Externí odkaz:
https://doaj.org/article/b82b754dd2874bbc89024fd998a49788
Autor:
Mohaned Benzarti, Laura Neises, Anais Oudin, Christina Krötz, Elodie Viry, Ernesto Gargiulo, Coralie Pulido, Maryse Schmoetten, Vitaly Pozdeev, Nadia I. Lorenz, Michael W. Ronellenfitsch, David Sumpton, Marc Warmoes, Christian Jaeger, Antoine Lesur, Björn Becker, Etienne Moussay, Jerome Paggetti, Simone P. Niclou, Elisabeth Letellier, Johannes Meiser
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113868- (2024)
Summary: Modeling tumor metabolism in vitro remains challenging. Here, we used galactose as an in vitro tool compound to mimic glycolytic limitation. In contrast to the established idea that high glycolytic flux reduces pyruvate kinase isozyme M2 (PK
Externí odkaz:
https://doaj.org/article/70167f7828434ce29cdc23c2703e97a7
Autor:
Catherine Delbrouck, Nicole Kiweler, Oleg Chen, Vitaly I. Pozdeev, Lara Haase, Laura Neises, Anaïs Oudin, Aymeric Fouquier d’Hérouël, Ruolin Shen, Lisa Schlicker, Rashi Halder, Antoine Lesur, Anne Schuster, Nadja I. Lorenz, Christian Jaeger, Maureen Feucherolles, Gilles Frache, Martyna Szpakowska, Andy Chevigne, Michael W. Ronellenfitsch, Etienne Moussay, Marie Piraud, Alexander Skupin, Almut Schulze, Simone P. Niclou, Elisabeth Letellier, Johannes Meiser
Publikováno v:
Cell Reports, Vol 42, Iss 9, Pp 113034- (2023)
Summary: Metabolic rewiring is essential for cancer onset and progression. We previously showed that one-carbon metabolism-dependent formate production often exceeds the anabolic demand of cancer cells, resulting in formate overflow. Furthermore, we
Externí odkaz:
https://doaj.org/article/d667e6854d774c98bcdedc3d5a151980
Autor:
Nicole Kiweler, Catherine Delbrouck, Vitaly I. Pozdeev, Laura Neises, Leticia Soriano-Baguet, Kim Eiden, Feng Xian, Mohaned Benzarti, Lara Haase, Eric Koncina, Maryse Schmoetten, Christian Jaeger, Muhammad Zaeem Noman, Alexei Vazquez, Bassam Janji, Gunnar Dittmar, Dirk Brenner, Elisabeth Letellier, Johannes Meiser
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Chemotherapeutic antifolates, such as methotrexate (MTX), impair cancer cell proliferation by inhibiting nucleotide synthesis. Here, the authors show that MTX sustains an autarkic mitochondrial one-carbon metabolism leading to serine synthesis to pro
Externí odkaz:
https://doaj.org/article/1b8b8042e550427e9245dff67e377dae
Publikováno v:
Cells, Vol 9, Iss 9, p 2035 (2020)
The metastatic cascade is a highly plastic and dynamic process dominated by cellular heterogeneity and varying metabolic requirements. During this cascade, the three major metabolic pillars, namely biosynthesis, RedOx balance, and bioenergetics, have
Externí odkaz:
https://doaj.org/article/879e1a016d6e49cc877b717cdeaea977
Autor:
Dionysios C. Watson, Defne Bayik, Simon Storevik, Shannon Sherwin Moreino, Samuel A. Sprowls, Jianhua Han, Mina Thue Augustsson, Adam Lauko, Palavalasa Sravya, Gro Vatne Røsland, Katie Troike, Karl Johan Tronstad, Sabrina Wang, Katharina Sarnow, Kristen Kay, Taral R. Lunavat, Daniel J. Silver, Sahil Dayal, Justin Vareecal Joseph, Erin Mulkearns-Hubert, Lars Andreas Rømo Ystaas, Gauravi Deshpande, Joris Guyon, Yadi Zhou, Capucine R. Magaut, Juliana Seder, Laura Neises, Sarah E. Williford, Johannes Meiser, Andrew J. Scott, Peter Sajjakulnukit, Jason A. Mears, Rolf Bjerkvig, Abhishek Chakraborty, Thomas Daubon, Feixiong Cheng, Costas A. Lyssiotis, Daniel R. Wahl, Anita B. Hjelmeland, Jubayer A. Hossain, Hrvoje Miletic, Justin D. Lathia
Publikováno v:
Nature Cancer. 4:648-664
The transfer of intact mitochondria between heterogeneous cell types has been confirmed in various settings, including cancer. However, the functional implications of mitochondria transfer on tumor biology are poorly understood. Here we show that mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e2cd76169f757aefbec27866da906b8
https://doi.org/10.1038/s43018-023-00556-5
https://doi.org/10.1038/s43018-023-00556-5
Autor:
Mohaned Benzarti, Anais Oudin, Elodie Viry, Ernesto Gargiulo, Maryse Schmoetten, Laura Neises, Coralie Pulido, Nadia I. Lorenz, Michael W. Ronellenfitsch, David Sumpton, Marc Warmoes, Christian Jaeger, Antoine Lesur, Etienne Moussay, Jerome Paggetti, Simone P. Niclou, Elisabeth Letellier, Johannes Meiser
Throughout the metastatic cascade, cancer cells are faced with harsh metabolic environments and nutritional stresses which apply selection pressure leaving only the most metabolically resilient cells to survive and form metastases. Metabolic characte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a522bab3a28454fca112d3efdad6bfe
https://doi.org/10.1101/2023.01.23.525168
https://doi.org/10.1101/2023.01.23.525168
Autor:
Catherine Delbrouck, Nicole Kiweler, Vitaly I. Pozdeev, Laura Neises, Anaïs Oudin, Anne Schuster, Aymeric Fouquier d’Hérouël, Ruolin Shen, Rashi Halder, Antoine Lesur, Christoph Ogris, Nadia I. Lorenz, Christian Jaeger, Michael W. Ronellenfitsch, Marie Piraud, Alexander Skupin, Simone P. Niclou, Elisabeth Letellier, Johannes Meiser
Metabolic rewiring is essential to enable cancer onset and progression. One important metabolic pathway that is often hijacked by cancer cells is the one-carbon cycle, in which the third carbon of serine is oxidized to formate. We have previously sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ecb9b1c6f36440a0d52dd55e5d9e89de
https://doi.org/10.1101/2023.01.23.525172
https://doi.org/10.1101/2023.01.23.525172
Autor:
Felix Wottawa, Björn Becker, Mohamed Bakr, Lisa Mayr, Julia Kugler, Samuel J Windross, Laura Neises, Silke van den Bossche, Nassim Kakavand, Florian Tran, Lina Welz, Julian Schwärzler, Zoltán Bánki, Stephanie Stengel, Go Ito, Olivia Coleman, Christian Jaeger, Eric Koncina, Elisabeth Letellier, Dirk Haller, Søren R Paludan, Richard Blumberg, Arthur Kaser, Luka Cicin-Sain, Stefan Schreiber, Timon Adolph, Philip Rosenstiel, Johannes Meiser, Konrad Aden
Mucosal cytomegalovirus (CMV) infection represents a leading cause for complicated disease behaviour and proctocolectomy in patients with inflammatory bowel disease (IBD). Using a genetic loss-of-function mouse model of the hypomorphic IBD risk gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4008398ae3c7b1bd1de7d7b721aea7c3
https://doi.org/10.1101/2022.05.17.492340
https://doi.org/10.1101/2022.05.17.492340