Mannose-binding lectin has a direct deleterious effect on ischemic brain microvascular endothelial cells

Autor: Maria Grazia De Simoni, Adriana Zanetti, Stefano Fumagalli, Carlo Perego, Franca Orsini, Laura Neglia

Publikováno v: Journal of Cerebral Blood Flow & Metabolism

Mannose-binding lectin (MBL), an initiator of the lectin pathway, is detrimental in ischemic stroke. MBL deposition on the ischemic endothelium indicates the beginning of its actions, but downstream mechanisms are not clear yet. We investigated MBL i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0361a210543ddb3dfe767f3a17dfc6
http://europepmc.org/articles/PMC7370363

Human brain trauma severity is associated with lectin complement pathway activation

Autor: Maria Grazia De Simoni, Fabrizio Ortolano, Nino Stocchetti, Daiana De Blasio, Franca Orsini, Stefano Fumagalli, Elisa R. Zanier, Luca Longhi, Carlo Perego, Edoardo Picetti, Marco Locatelli, Peter Garred, Laura Neglia

Publikováno v: Journal of Cerebral Blood Flow & Metabolism
De Blasio, D, Fumagalli, S, Orsini, F, Neglia, L, Perego, C, Ortolano, F, Zanier, E R, Picetti, E, Locatelli, M, Stocchetti, N, Longhi, L, Garred, P & De Simoni, M 2019, ' Human brain trauma severity is associated with lectin complement pathway activation ', Journal of Cerebral Blood Flow and Metabolism, vol. 39, no. 5, pp. 794-807 . https://doi.org/10.1177/0271678X18758881

We explored the involvement of the lectin pathway of complement in post-traumatic brain injury (TBI) pathophysiology in humans. Brain samples were obtained from 28 patients who had undergone therapeutic contusion removal, within 12 h (early) or from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e4d75c8ad689a8e3f6d0feb3514cc96
http://europepmc.org/articles/PMC6501516