Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Laura N. Rusché"'
Autor:
Christopher B. Rupert, Laura N. Rusche
Publikováno v:
mSphere, Vol 7, Iss 3 (2022)
ABSTRACT Candida parapsilosis is an emerging fungal pathogen that primarily affects immunocompromised patients in hospitals. A significant risk factor is the use of implanted medical devices, which support the growth of biofilms composed of a mixture
Externí odkaz:
https://doaj.org/article/a1eaa57a0c194f00926ec06e336060db
Autor:
Laura N. Rusche
Publikováno v:
mBio, Vol 12, Iss 4 (2021)
ABSTRACT Candida auris is an emerging fungal pathogen that is thermotolerant and often resistant to standard antifungal treatments. To trace its evolutionary history, the Sanyal lab conducted a comparative genomic study focusing on the positions of c
Externí odkaz:
https://doaj.org/article/38a2f68222864ab596dbbb4ccdad3b69
Autor:
Guolei Zhao, Laura N. Rusche
Publikováno v:
mSphere, Vol 6, Iss 3 (2021)
Candida albicans
Externí odkaz:
https://doaj.org/article/91cc7670a1044466a624c5429320ea03
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 10, Pp 3297-3305 (2016)
Gene duplication promotes the diversification of protein functions in several ways. Ancestral functions can be partitioned between the paralogs, or a new function can arise in one paralog. These processes are generally viewed as unidirectional. Howev
Externí odkaz:
https://doaj.org/article/5b6e1c5bf530401d940f4efb444676be
Autor:
Hung-Ji Tsai, Joshua A. Baller, Ivan Liachko, Amnon Koren, Laura S. Burrack, Meleah A. Hickman, Mathuravani A. Thevandavakkam, Laura N. Rusche, Judith Berman
Publikováno v:
mBio, Vol 5, Iss 5 (2014)
ABSTRACT Origins of DNA replication are key genetic elements, yet their identification remains elusive in most organisms. In previous work, we found that centromeres contain origins of replication (ORIs) that are determined epigenetically in the path
Externí odkaz:
https://doaj.org/article/70e68d4e98f34ef9b64f1dcf46320fb4
Autor:
Michael T. Hemann, Catherine E. Huang, K.J. Piller, Barbara Sollner-Webb, Laura N. Rusché, Elizabeth Wirtz
Publikováno v:
Molecular and Cellular Biology. 21:979-989
In kinetoplastid protozoans, many mitochondrial transcripts undergo RNA editing, a specific insertion and deletion of U residues at multiple sites, directed by guide RNAs (reviewed in references 2, 13, 15, 38, and 39). Both U deletional and U inserti
Publikováno v:
Molecular and Cellular Biology. 21:884-892
Trypanosome RNA editing is a massive processing of mRNA by U deletion and U insertion, directed by trans-acting guide RNAs (gRNAs). A U deletion cycle and a U insertion cycle have been reproduced in vitro using synthetic ATPase (A6) pre-mRNA and gRNA
Publikováno v:
The EMBO Journal. 16:4069-4081
Kinetoplastid mitochondrial RNA editing, the insertion and deletion of U residues, is catalyzed by sequential cleavage, U addition or removal, and ligation reactions and is directed by complementary guide RNAs. We have purified a approximately 20S en
Publikováno v:
Journal of Biological Chemistry. 271:4613-4619
RNA editing in kinetoplastids is the post-transcriptional insertion and deletion of uridylate residues in mitochondrial transcripts, directed by base pairing with guide RNAs. Models for editing propose transesterification or endonuclease plus RNA lig
Publikováno v:
Molecular and Cellular Biology. 15:2925-2932
RNA editing in trypanosomes has been proposed to occur through transesterification or endonuclease cleavage and RNA ligation reactions. Both models involve a chimeric intermediate in which a guide RNA (gRNA) is joined through its 3' oligo(U) tail to