Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Laura N. Mutton"'
Autor:
Charles J. Bieberich, Angelo M. De Marzo, Srinivasan Yegnasubramanian, Peter S. Nelson, Michael S. Moubarek, Ibrahim Kulac, Lucas A. Horn, Daniella Bianchi-Frias, Jessica L. Hicks, Ryan P. McMullin, May Khalili, Laura N. Mutton, Gretchen K. Hubbard
Genetic instability, a hallmark feature of human cancers including prostatic adenocarcinomas, is considered a driver of metastasis. Somatic copy number alterations (CNA) are found in most aggressive primary human prostate cancers, and the overall num
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5f4962b0ffc42ccd0b4f93315e5992
https://doi.org/10.1158/0008-5472.c.6507936.v1
https://doi.org/10.1158/0008-5472.c.6507936.v1
Autor:
Charles J. Bieberich, Angelo M. De Marzo, Srinivasan Yegnasubramanian, Peter S. Nelson, Michael S. Moubarek, Ibrahim Kulac, Lucas A. Horn, Daniella Bianchi-Frias, Jessica L. Hicks, Ryan P. McMullin, May Khalili, Laura N. Mutton, Gretchen K. Hubbard
Supplementary Figure 1 Morphology of PIN in B13-MYC mice. Supplementary Figure 2 Phenotypic analysis of PIN in a B13-MYC mouse (ventral lobe, 52 weeks old). Supplementary Figure 3 Additional phenotypic analysis of B-MYC/Pten mouse PIN (anterior lobe,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a07c8677f7c45ab0a0216f1045565a3
https://doi.org/10.1158/0008-5472.22410195
https://doi.org/10.1158/0008-5472.22410195
Autor:
Tsuyoshi Iwata, Denise Schultz, Jessica Hicks, Gretchen K Hubbard, Laura N Mutton, Tamara L Lotan, Carlise Bethel, Matthew T Lotz, Srinivasan Yegnasubramanian, William G Nelson, Chi V Dang, MengMeng Xu, Uzoma Anele, Cheryl M Koh, Charles J Bieberich, Angelo M De Marzo
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9427 (2010)
Lo-MYC and Hi-MYC mice develop prostatic intraepithelial neoplasia (PIN) and prostatic adenocarcinoma as a result of MYC overexpression in the mouse prostate. However, prior studies have not determined precisely when, and in which cell types, MYC is
Externí odkaz:
https://doaj.org/article/59ed23f304684ff8b997f9f9164b889e
Autor:
Lucas A. Horn, Ibrahim Kulac, Charles J. Bieberich, Angelo M. De Marzo, Ryan P. McMullin, Gretchen K. Hubbard, Daniella Bianchi-Frias, May Khalili, Laura N. Mutton, Michael S. Moubarek, Jessica L. Hicks, Srinivasan Yegnasubramanian, Peter S. Nelson
Publikováno v:
Cancer Research. 76:283-292
Genetic instability, a hallmark feature of human cancers including prostatic adenocarcinomas, is considered a driver of metastasis. Somatic copy number alterations (CNA) are found in most aggressive primary human prostate cancers, and the overall num
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17ed46907f0cf1aad52b625586397eb0
https://doi.org/10.1158/0008-5472.can-14-3280
https://doi.org/10.1158/0008-5472.can-14-3280
Autor:
Laura N. Mutton, Charles J. Bieberich, Aminah Wali, Varsha Rao, Jamie C. Heard, Helya Ghaffari
Publikováno v:
The Prostate. 72:1045-1051
BACKGROUND Genetically engineered mouse models play important roles in analyses of prostate development and pathobiology. While constitutive genetic gain- and loss-of-function models have contributed significantly to our understanding of molecular ev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff2990a5845b00b356f3a66b5b1682b8
https://doi.org/10.1002/pros.22490
https://doi.org/10.1002/pros.22490
Autor:
May Khalili, Laura N. Mutton, Jessica Hicks, Bora Gurel, Charles J. Bieberich, Angelo M. De Marzo
Publikováno v:
The American Journal of Pathology. 176:2259-2268
NKX3.1 is a homeodomain protein that functions as a dosage sensitive prostate-specific transcription factor. Diminished NKX3.1 expression is associated with prostate epithelial cell proliferation in vitro and with increasing Gleason grade in patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fd0a6c540fa8b2defea618445045557
https://doi.org/10.2353/ajpath.2010.080747
https://doi.org/10.2353/ajpath.2010.080747
Autor:
Cooduvalli S. Shashikant, Albert Dobi, Charles J. Bieberich, András Orosz, Shilpi Maheshwari, Laura N. Mutton, Ryan P. McMullin
Publikováno v:
Proceedings of the National Academy of Sciences. 107:98-103
Hoxb13 is robustly transcribed in derivatives of posterior endoderm including the colon, rectum, and the prostate gland. Transcriptional activity in the prostate persists unabated under conditions of androgen deprivation and throughout the course of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450bac85e1a8a00dd30116d85db80531
https://doi.org/10.1073/pnas.0902001107
https://doi.org/10.1073/pnas.0902001107
Autor:
Eric H. Rubin, Pooja Pungaliya, Carlos Uquillas, Bin Guan, Laura N. Mutton, Xiang Li, Charles J. Bieberich
Publikováno v:
Journal of Biological Chemistry. 283:4834-4840
The NKX3.1 gene located at 8p21.2 encodes a homeodomain-containing transcription factor that acts as a haploinsufficient tumor suppressor in prostate cancer. Diminished protein expression of NKX3.1 has been observed in prostate cancer precursors and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63e6f31d11230b05c6db1d2c500afe08
https://doi.org/10.1074/jbc.m708630200
https://doi.org/10.1074/jbc.m708630200
Reduced expression of the homeodomain transcription factor NKX3.1 is associated with prostate cancer initiation and progression. NKX3.1 turnover requires post-translational modifications including phosphorylation and ubiquitination. Here, we demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458e48d2bf998e48cb71d6039f01d2c1
https://europepmc.org/articles/PMC3476300/
https://europepmc.org/articles/PMC3476300/
Autor:
Charles J. Bieberich, Chi V. Dang, Angelo M. De Marzo, Matthew T. Lotz, Tamara L. Lotan, William G. Nelson, Jessica L. Hicks, Denise Schultz, Uzoma A. Anele, Cheryl M. Koh, Laura N. Mutton, Gretchen K. Hubbard, Carlise R. Bethel, Tsuyoshi Iwata, Srinivasan Yegnasubramanian, Meng Meng Xu
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 2, p e9427 (2010)
PLoS ONE, Vol 5, Iss 2, p e9427 (2010)
Lo-MYC and Hi-MYC mice develop prostatic intraepithelial neoplasia (PIN) and prostatic adenocarcinoma as a result of MYC overexpression in the mouse prostate[1]. However, prior studies have not determined precisely when, and in which cell types, MYC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9addcfec018982d358ef22b035b50bb7
https://pubmed.ncbi.nlm.nih.gov/20195545
https://pubmed.ncbi.nlm.nih.gov/20195545