Výsledky vyhledávání - "Laura N. F. Cardoso"

Akademický článek

Different packing motifs of isomeric (E)-N′-(halophenylmethylidene)-N-methyl-2-(thiophen-2-yl)acetohydrazides controlled by C—H...O interactions

Autor: Laura N. F. Cardoso, Thais C. M. Noguiera, James L. Wardell, Marcus V. N. de Souza, William T. A. Harrison

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 74, Iss 3, Pp 313-318 (2018)

The crystal structures of three isomeric (E)-N′-(chlorophenylmethylidene)-N-methyl-2-(thiophen-2-yl)acetohydrazides (C14H13ClN2OS) are described, with the Cl atom in ortho (I), meta (III) and para (IV) positions in the benzene ring. The ortho-bromo

Externí odkaz: https://doaj.org/article/624e0608e09c4e7db97e93e71811c7fa

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Akademický článek

Crystal structures and Hirshfeld surfaces of differently substituted (E)-N′-benzylidene-N-methyl-2-(thiophen-2-yl)acetohydrazides

Autor: Laura N. F. Cardoso, Thais C. M. Noguiera, Carlos R. Kaiser, James L. Wardell, Marcus V. N. de Souza, William T. A. Harrison

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 73, Iss 11, Pp 1636-1641 (2017)

The syntheses and crystal structures of (E)-N′-(3-cyanobenzylidene)-N-methyl-2-(thiophen-2-yl)acetohydrazide, C15H13N3OS, (I), and (E)-N′-(4-methoxybenzylidene)-N-methyl-2-(thiophen-2-yl)acetohydrazide, C15H16N2O2S, (II), with different substitue

Externí odkaz: https://doaj.org/article/1fb32001cf274689af1afd463943db33

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Akademický článek

Different weak interactions in the crystals of three isomeric (E)-N-methyl-N′-(nitrobenzylidene)-2-(thiophen-2-yl)acetohydrazides

Autor: Laura N. F. Cardoso, Thais C. M. Noguiera, Carlos R. Kaiser, James L. Wardell, Marcus V. N. de Souza, Shaun T. Lancaster, William T. A. Harrison

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 72, Iss 12, Pp 1677-1682 (2016)

The crystal structures of three isomeric (E)-N-methyl-N′-(nitrobenzylidene)-2-(thiophen-2-yl)acetohydrazides (formula C14H13N3O3S) are described, with the nitro group in ortho, meta and para positions in the benzene ring. In each crystal structure,

Externí odkaz: https://doaj.org/article/bafe460d89024a84ab4d31913ed59ac5

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Akademický článek

N′-[(1E)-(5-Nitrofuran-2-yl)methylidene]thiophene-2-carbohydrazide: crystal structure and Hirshfeld surface analysis

Autor: Laura N. F. Cardoso, Thais C. M. Nogueira, James L. Wardell, Solange M. S. V. Wardell, Marcus V. N. de Souza, Mukesh M. Jotani, Edward R. T. Tiekink

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 72, Iss 7, Pp 1025-1031 (2016)

In the title carbohydrazide, C10H7N3O4S, the dihedral angle between the terminal five-membered rings is 27.4 (2)°, with these lying to the same side of the plane through the central CN2C(=O) atoms (r.m.s. deviation = 0.0403 Å), leading to a curved

Externí odkaz: https://doaj.org/article/e06befb787fd4515a8601e19eeadebde

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Akademický článek

Anti-Mycobacterial Evaluation of 7-Chloro-4-Aminoquinolines and Hologram Quantitative Structure–Activity Relationship (HQSAR) Modeling of Amino–Imino Tautomers

Autor: Marcelle L. F. Bispo, Camilo H. S. Lima, Laura N. F. Cardoso, André L. P. Candéa, Flávio A. F. M. Bezerra, Maria C. S. Lourenço, Maria G. M. O. Henriques, Ricardo B. Alencastro, Carlos R. Kaiser, Marcus V. N. Souza, Magaly G. Albuquerque

Publikováno v: Pharmaceuticals, Vol 10, Iss 2, p 52 (2017)

In an ongoing research program for the development of new anti-tuberculosis drugs, we synthesized three series (A, B, and C) of 7-chloro-4-aminoquinolines, which were evaluated in vitro against Mycobacterium tuberculosis (MTB). Now, we report the ant

Externí odkaz: https://doaj.org/article/1bd0b3f01c1141e3a7d926e13ac67d2d

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Experimental and computational evidence for stabilising parallel, offset π[C(O)N(H)NC]⋯π(phenyl) interactions in acetohydrazide derivatives

Autor: Sang Loon Tan, Laura N. F. Cardoso, Marcus V. N. de Souza, Solange M. S. V. Wardell, James L. Wardell, Edward R. T. Tiekink

Publikováno v: CrystEngComm. 24:962-974

Stabilising π[C(O)N(H)NC]⋯π(phenyl) interactions are described.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1fb65e404184658b034ab560501cd742
https://doi.org/10.1039/d1ce01492g

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Different packing motifs of isomeric (E)-N′-(halophenylmethylidene)-N-methyl-2-(thiophen-2-yl)acetohydrazides controlled by C—H...O interactions

Autor: James L. Wardell, Thais C. M. Noguiera, William T. A. Harrison, Laura N. F. Cardoso, M.V.N. de Souza

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 74, Iss 3, Pp 313-318 (2018)
Acta Crystallographica Section E: Crystallographic Communications

The packing motifs in the isomeric title compounds feature inversion dimers or chains, mediated by C—H⋯O interactions, one of which is unusually short (H⋯O = 2.18 Å).
The crystal structures of three isomeric (E)-N′-(chlorophenylme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12ad9214d7e707a0d58fb2d550d5b360
http://scripts.iucr.org/cgi-bin/paper?S2056989018001251

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N-acylhydrazones containing thiophene nucleus: a new anticancer class

Autor: Felipe A. R. Rodrigues, Thais Cristina Mendonça Nogueira, Maria Claudia dos Santos Luciano, Augusto César Aragão Oliveira, Claudia Pessoa, Marcus V. N. de Souza, Laura N. F. Cardoso

Publikováno v: Medicinal Chemistry Research. 26:1605-1608

In this study, we present a series of N-acylhydrazones containing thiophene nuclei as a new anticancer class. Fifty-seven compounds in this series were evaluated for their activity against four human cancer cell lines. Cytotoxicity (IC50) ranged from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3f1a512743165b78ef7ae52355411b20
https://doi.org/10.1007/s00044-017-1832-y

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Different weak interactions in the crystals of three isomeric (E)-N-methyl-N′-(nitrobenzylidene)-2-(thiophen-2-yl)acetohydrazides

Autor: William T. A. Harrison, James L. Wardell, Laura N. F. Cardoso, Marcus V. N. de Souza, Thais C. M. Noguiera, Shaun T. Lancaster, Carlos R. Kaiser

Publikováno v: Acta Crystallographica Section E: Crystallographic Communications, Vol 72, Iss 12, Pp 1677-1682 (2016)
Acta Crystallographica Section E: Crystallographic Communications

Three isomeric methylated 2-(thiophen-2-yl)acetohydrazides show little consistency in the pattern of weak (C—H⋯O, C—H⋯π and π–π) interactions in their crystal structures.
The crystal structures of three isomeric (E)-N-methyl-N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5338b65801748a56703925c53b5bbcf9
https://doi.org/10.1107/s2056989016016856

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Synthesis and anti-tubercular activity of Thienyl and Furanyl derivatives

Autor: Laura N. F. Cardoso, Marcus V. N. de Souza, Solange M. S. V. Wardell, Thais C.M. Nogueira, James L. Wardell, Carlos R. Kaiser

Publikováno v: Mediterranean Journal of Chemistry. 5:356-366

The synthesis and anti-tubercular activity of series of acyl hydrazonyl compounds, namely ( E )- N' -(arylidene)thiophen-2-carbohydrazide, ( E )- N' -(arylidene)furan-2-carbohydrazide, ( E )- N -methyl- N' -arylidene-thiophen-2-carbohydrazide, and E

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aae8f484fe8b7f5346f503d4c6dc9657
https://doi.org/10.13171/mjc.5.1/0160213/desouza

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