Signal transduction in Plasmodium-Red Blood Cells interactions and in cytoadherence

Autor: Laura N. Cruz, Yang Wu, Alister G. Craig, Célia R.S. Garcia

Publikováno v: Anais da Academia Brasileira de Ciências, Vol 84, Iss 2, Pp 555-572 (2012)

Malaria is responsible for more than 1.5 million deaths each year, especially among children (Snow et al. 2005). Despite of the severity of malaria situation and great effort to the development of new drug targets (Yuan et al. 2011) there is still a

Externí odkaz: https://doaj.org/article/29b3f8f4fb424ab584dd124affa1f405

FRET peptides reveal differential proteolytic activation in intraerythrocytic stages of the malaria parasites Plasmodium berghei and Plasmodium yoelii

Autor: Philip J. Rosenthal, Eduardo Alves, Célia R.S. Garcia, Maria A. Juliano, Mônica Teixeira Leal, Laura N. Cruz, Luiz Juliano

Publikováno v: International Journal for Parasitology. 41:363-372

Malaria is still a major health problem in developing countries. It is caused by the protist parasite Plasmodium , in which proteases are activated during the cell cycle. Ca 2+ is a ubiquitous signalling ion that appears to regulate protease activity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c3d861fe6a7b46488d435d6b34ef8a7
https://doi.org/10.1016/j.ijpara.2010.10.009

An external sensing system in Plasmodium falciparum-infected erythrocytes

Autor: Yang, Wu, Laura N, Cruz, Tadge, Szestak, Gavin, Laing, Gemma R, Molyneux, Celia R S, Garcia, Alister G, Craig

Publikováno v: Malaria Journal

Background A number of experiments have previously indicated that Plasmodium falciparum-infected erythrocytes (pRBC) were able to sense host environment. The basis of this ability to detect external cues is not known but in screening signalling molec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8a067ac49bdb8615a7e13b166611b505
https://pubmed.ncbi.nlm.nih.gov/26893139

Investigation of antimalarial activity, cytotoxicity and action mechanism of piperazine derivatives of betulinic acid

Autor: Miriam S. Moraes, Célia R.S. Garcia, Gloria Narjara Santos da Silva, Laura N. Cruz, Desirée Cigaran Schuck, Simone Cristina Baggio Gnoatto, Myna Nakabashi, Grace Gosmann

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Objectives To semisynthesise piperazine derivatives of betulinic acid to evaluate antimalarial activity, cytotoxicity and action mechanism. Methods The new derivatives were evaluated against the CQ-sensitive Plasmodium falciparum 3D7 strain by flow c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e97de3f2acf53e4f9125e259a6ef43

Biological evaluation of hydroxynaphthoquinones as anti-malarials

Autor: Sabrina Baptista Ferreira, David R. da Rocha, Philip J. Rosenthal, Myna Nakabashi, Laura N. Cruz, Célia R.S. Garcia, Miriam S. Moraes, Vitor F. Ferreira, Desirée Cigaran Schuck

Publikováno v: Rosenthal, Philip; Schuck, DC; Ferreira, SB; Cruz, LN; Da, DR; Moraes, MS; et al.(2013). Biological evaluation of hydroxynaphthoquinones as anti-malarials. UC San Francisco: Retrieved from: http://www.escholarship.org/uc/item/7mg0k6zw
Malaria Journal
Schuck, Desiree C; Ferreira, Sabrina B; Cruz, Laura N; da Rocha, David R; Moraes, Miriam S; Nakabashi, Myna; et al.(2013). Biological evaluation of hydroxynaphthoquinones as anti-malarials. Malaria Journal, 12(1), 234. doi: http://dx.doi.org/10.1186/1475-2875-12-234. Retrieved from: http://www.escholarship.org/uc/item/85k849tn

Background The hydroxynaphthoquinones have been extensively investigated over the past 50 years for their anti-malarial activity. One member of this class, atovaquone, is combined with proguanil in Malarone®, an important drug for the treatment and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32f9c4e1c8d9d6193ae16beb96fda408
http://www.escholarship.org/uc/item/7mg0k6zw